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  • 1
    Electronic Resource
    Electronic Resource
    Effect of combined or separate administration of piracetam and choline on learning and memory in the rat (1987)
    Springer
    Psychopharmacology 92 (1987), S. 58-67 
    Details
    ISSN: 1432-2072
    Keywords: Piracetam ; Choline ; Piracetam + choline ; Delayed alternation ; Two-way avoidance ; Object recognition ; 5-HT ; CAT ; Choline uptake ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect. Moreover, rats receiving P2C1 and P4C1 were significantly inferior in acquiring DA to rats receiving the vehicle or separate administration of P1, P2 or C1. The different treatments with combined or separate administration of P and C had no effect on spontaneous locomotor activity and two-way avoidance conditioning. In a recognition-task only groups C1 and P4 were able to discriminate between familiar and new objects. The combined or separate administration of P1 and C1 on NA, DA, DOPAC, 5-HT, 5-HIAA levels, CAT activity and choline uptake were measured in frontal cortex and hippocampus: the only significant effect was a 5-HT increase in the hippocampus of rats treated with C1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215480
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The roman strains of rats as a psychogenetic tool for pharmacological investigation of working memory: example with RU 41656 (1992)
    Springer
    Psychopharmacology 107 (1992), S. 415-424 
    Details
    ISSN: 1432-2072
    Keywords: Roman strains ; Psychogenetic selection ; Working memory ; Exploratory behaviour ; Spontaneous alternation ; Radial maze ; Object recognition ; Acetylcholine ; Dopamine ; Noradrenaline ; Serotonin ; Hippocampus ; Frontal cortex ; Striatum ; RU 41656 ; D2 agonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined the effects of RU 41656, a dopaminergic D2 agonist, on the differential working memory performances and on the differential activities of the neurochemical systems of the Roman high (RHA) and Roman low (RLA) avoidance strains of rats. Compared with RLA, RHA performed worse in three tests of working memory (spontaneous alternation, radial maze and object recognition) and had higher levels of exploratory locomotor activity. Hippocampal and frontal cortex choline acetyltransferase (ChAT) activities were loer in RHA. Frontal cortex DA and DOPAC levels, hippocampal and striatal 5-HT and NA levels were higher in RHA. RU 41656 induced a significant improvement in working memory performance of RHA, whereas in RLA it had no effect. It decreased exploratory locomotor activity in both strains. ChAT activity in hippocampus was not affected by RU 41656 in either strain, whereas in frontal cortex it was increased in RHA but not in RLA. Hippocampal NA levels were decreased by RU 41656 in RHA but not in RLA. These results confirm previous data concerning the promnesic effect of RU 41656 and extend the finding that the Roman strains are a psychogenetic model for the behavioural, neurochemical and psychopharmacological study of the working memory in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245169
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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