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  • Gastric carcinoma  (4)
  • 5-Jahres-Überlebensrate  (1)
  • Arteriovenöse Shunts  (1)
  • 1
    Electronic Resource
    Electronic Resource
    134. Spezielle Techniken der Shunt-Chirurgie (1976)
    Springer
    Langenbeck's archives of surgery 342 (1976), S. 596-596 
    Details
    ISSN: 1435-2451
    Keywords: Shunt, arteriovenous ; Heparinisation, local ; Graft, heterologous ; Arteriovenöse Shunts ; Lokale Heparinisierung ; Heterologer Gefäßersatz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An der Medizinischen Hochschule Hannover wurden über 1000 Shunt-Operationen durchgeführt, darunter 18mal mit der Basilica, 23 Fälle mit Saphena-Interposition, 21 mit heterologem Gefäßersatz (Kälberarterien). Nach den Ergebnissen mit Letztgenanntem wird das Saphenainterponat kaum noch benötigt, der Eingriff vereinfacht sich. Spezielle Techniken: (1) Für den subcutanen Durchzug von Interponaten werden Drainageschläuche mit Spieß verwandt. (2) Bei rezidivierenden Thrombosen wird eine lokale Heparinisierung durchgeführt mit 5–10000 E/24 h über 3–5 Tage mittels eines dünnen Intracaths, der 15 cm in den zuführenden arteriellen Schenkel eingebracht wird. 12 von 18 Shunts bzw. Interponate konnten offengehalten und vor der definitiven Thrombose bewahrt werden. (3) Zur Überbrückung kurzstreckiger Läsionen wie Stenosen, Aneurysmen oder Ruptur eines Xenografts unter infizierten Wunden (2 Fälle!) wurden kurze Segmente von heterologem Gefäßersatz interponiert.
    Notes: Summary At Hannover Medical School, 1000 shunt procedures have been performed, including anastomosis with the basilic vein (18 cases), interposition of the saphenous vein (23 cases) or of a bovine xenograft (21 cases), used straight or as a loop. Lately the authors have used xenografts instead of the autologous saphenous vein, thereby easing anesthesia and the actual operation. Some special techniques are used: (1) pulling through of interposed vessels is facilitated by using rubber tubes that are subcutaneously channeled on a rod; (2) in repeated thrombosis of a shunt, local heparinization is instituted with 5–10000 U/24 h over 3–5 days via a small Intracath, the tip of which is brought up 15 cm into the arterial shunt vessel. In this way, 12 of 18 shunts were kept open and saved from definite thrombosis; (3) in cases with lesions such as stenosis, aneurysm or rupture of a xenograft after puncture wound infection (2 cases), interposition of a short segment xenograft helped to save the shunts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01267481
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  • 2
    Electronic Resource
    Electronic Resource
    Perspectives of surgery and multimodality treatment in gastric carcinoma (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 384-394 
    Details
    ISSN: 1432-1335
    Keywords: Gastric carcinoma ; Gastric surgery ; Multimodality treatment ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Surgery still represents the therapy of choice for patients with primary gastric adenocarcinoma. The best survival results can be achieved if a potentially curative (R0) resection can be performed whatever the extent of resection of the primary tumor (total versus subtotal distal gastrectomy). Either procedure should be accompanied by systematic lymph node dissection since lymphadenectomy has relevant diagnostic (i.e. staging) and therapeutic implications (i.e. improved survival in stage II/IIIA disease). Since most gastric carcinomas are diagnosed in advanced tumor stages, the number of patients to be treated curatively by surgery alone remains limited. Multimodality treatment, consisting of chemotherapy and surgery, may be an encouraging alternative strategy. With actual chemotherapy protocols (i.e. 5-FU/doxorubicin/methotrexate, etoposide/doxorubicin/cisplatin) high remission rates in locally advanced irresectable lesions without distant metastases can be induced. Survival in these patients has been significantly improved after chemotherapy and second-look surgery. The effectiveness of these protocols in an adjuvant setting seems a worthwhile study for the future. In addition, immunological and somatic gene therapy may be of therapeutic impact in the next decade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01218419
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  • 3
    Electronic Resource
    Electronic Resource
    Expression ofHer2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric carcinoma (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 474-479 
    Details
    ISSN: 1432-1335
    Keywords: Her2/neu oncogene product p185 ; Gastric carcinoma ; Clinicopathological variables ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of theHer2/neu gene product p 185 was retrospectively analyzed in 58 patients with gastric carcinoma. The results were correlated to various clinicopathological and prognostic factors. Positive membrane staining for p185 could be detected in 38% of the patients (22/58). Membrane staining was significantly greater in well and moderately differentiated tumors of the intestinal type when compared with poorly differentiated lesions and carcinomas of the diffuse type (P〈0.01). Positive membrane staining did not correlate with site and tumor stage, but T1 lesions had less membrane staining than more advanced primary tumors. Overall survival showed no difference between p185-positive and negative cases. Multivariate analysis defined a subgroup of curatively resected patients with stage III and IV disease that had a statistically significant poorer survival when p185 was overexpressed (P=0.005). Overexpression of theHer2/neu product p185 appears to be associated with intestinal-type gastric carcinoma and may sociated with intestinal-type gastric carcinoma and may help in identifying a subset of patients at increased risk for shorter survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01629433
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  • 4
    Electronic Resource
    Electronic Resource
    233. Ansatzpunkte zur Verbesserung der Resektionsquote beim fortgeschrittenen Magencarcinom mit einem neuen präoperativen Chemotherapiekonzept (EAP) (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 870-870 
    Details
    ISSN: 1435-2451
    Keywords: Gastric carcinoma ; Chemotherapy ; EAP ; Second-look operation ; Magencarcinom ; Chemotherapie ; EAP ; Sekundäreingriff
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Etoposid, Adriamycin und Cisplatin (EAP) führten bei 55 Patienten (Pat.) mit fortgeschrittenem Magencarcinom zu einer partiellen und kompletten Remission (PR + CR) von 70%. 16 Pat. hatten ein lokal fortgeschrittenes, primär irresektables Carcinom. Die PR + CR betrug hier 87% (14/16). 8 dieser Pat. wurden einem Sekundäreingriff zugeführt. Neben anderen Verfahren war in 4 Fällen eine Gastrektomie möglich. Die CR bestätigte sich bei 5 Pat. auch histologisch. Die Resektionsquote beim lokal fortgeschrittenen Magencarcinom mag durch präop. Gabe von EAP verbessert werden.
    Notes: Summary Etoposide, adriamycin, and cisplatin (EAP) led to partial or complete remission (PR + CR) in 70% in 55 patients with advanced gastric carcinoma. Sixteen patients had local advanced tumors for which primary resection was not possible. PR + CR was 87% (14/16) in this group. In eight patients, a second-look operation was performed. Among other procedures, gastrectomy was achievable in 4 cases. CR was confirmed histologically in 5 patients. The resectability rate in locally advanced gastric carcinoma may improve after preoperative application of EAR
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298017
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  • 5
    Electronic Resource
    Electronic Resource
    Ermöglichen immunologische Marker eine Differenzierung zwischen den histologischen Typen des Magenkarzinoms? (1990)
    Springer
    Langenbeck's archives of surgery 375 (1990), S. 135-140 
    Details
    ISSN: 1435-2451
    Keywords: Gastric carcinoma ; Keratin ; Villin ; Brush border hydrolases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Siebzehn Magenkarzinome (intestinal n=12; diffus n=1; Mischtyp n=4) und ein BarrettKarzinom wurden prospektiv hinsichtlich der Expression verschiedener Keratinpolypeptide sowie der Bürsten-saummarker Villin, Sucrase Isomaltase and Aminopeptidase N immunfluoreszenzmikroskopisch untersucht. Unabhängig vom histologischen Typ exprimierten alle Karzinome die Keratinpolypeptide 8, 18 and 19 and reagierten mit dem breit spezifischen Keratinantikbrper KL1. Das Keratin 7 hingegen wurde nur in einem Karzinom von nahezu allen Tumorzellen and bei zwei weiteren Karzinomen nur von einigen Tumorzellen exprimiert. Die weitergehende Differenzierung der verschiedenen hi stologischen Typen des Magenkarzinoms ist mit Hilfe der Keratinantikörper nicht m6glich. Villin war in 80% aller Karzinome and Sucrase Isomaltase and Aminopeptidase N waren in je 67%, wiederum ohne histologiespezifische Unterschiede, positiv. Die Nachweisbarkeit der Bürstensaummarker, charakteristisches Kennzeichen des intestinalen Epithels, verdeutlicht das hohe Maß der intestinalen Differenzierung der Magenkarzinome, ohne daß eine Zuordnung zu bestimmten histologischen Typen möglich erscheint.[/p]
    Notes: Summary Seventeen gastric carcinomas (intestinal n=12; diffuse n=1; mixed type n=4) and one Barrett's carcinoma were prospectively studied by immunohistochemistry for the expression of different keratin polypeptides and of the brush border markers villin, sucrase isomaltase and aminopeptidase N. All carcinomas expressed the keratin polypeptides 8, 18, and 19 and were stained by the broad specific keratin antibody KL1, irrespective of histologic type. Keratin 7, however, was expressed in only one carcinoma in most tumor cells and in two further carcinomas in some tumor cells. Thus, specific differentiation of the various histologic types of gastric carcinoma does not seem to be aided by the use of keratin antibodies. Villin was positive in 80% of the tumors and sucrase isomaltase and aminopeptidase N were positive in 67% respectively with no obvious histologic difference. The frequent positivity of the brush border markers, usually typical for intestinal epithelium, reflects the high degree of intestinal differentiation of gastric carcinomas, but again does not seem to be associated with a particular histologic type.[/p]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206805
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  • 6
    Electronic Resource
    Electronic Resource
    230. Weitere Ergebnisse der prinzipiellen (totalen) Gastrektomie beim Magencarcinom (1979)
    Springer
    Langenbeck's archives of surgery 349 (1979), S. 579-580 
    Details
    ISSN: 1435-2451
    Keywords: Gastric cancer ; 5-year survival rate ; Gastrectomy “de principe” ; Surgery of “clinical staging” ; Magencarcinom ; 5-Jahres-Überlebensrate ; Gastrektomie aus Prinzip ; Stadiengerechte Chirurgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1968–1978 wurden von 889 Magencarcinomoperationen 290 Gastrektomien (47,9% der Resektionen) durchgeführt. Bei der prinzipiellen Gastrektomie (seit 1974) wurde mit 41,5% 5-Jahres-Überlebenszeit ein deutlich besseres Ergebnis gegenüber 12,5 % bei der Gastrektomie aus Notwendigkeit erreicht. Im Vergleich zu Resektionen = ≫tadiengerechte Chirurgie≪ konnte bisher kein signifikant besseres Ergebnis erzielt werden. Vergleichende Bewertung dieser Verfahren ist z. Z. wegen der schwierigen prä- und intraoperativen Bestimmung von Tumorausdehnung, -stadium und -typ u. E. kaum möglich.
    Notes: Summary Between 1968 and 1978 290 total gastrectomies, of 889 operations for gastric cancer, were performed 47.9% of the resections. Since 1974 gastrectomy “de principe” was carried out with an improved 5-year survival rate of 41.5% compared to 12.5% of gastrectomy “de nécessité”. Following gastric resections, i.e. surgery of “clinical staging”, statistically better results could not be obtained. At present a meaningful comparison is not possible due to the difficult determination of tumor expanding, clinical staging and grading pre- and intraoperatively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01729690
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