ISSN:
1573-904X
Keywords:
5-fluoro-2′-deoxyuridine ester
;
ester prodrug
;
esterase
;
hydrolysis
;
enzyme specificity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The chemical and enzymatic reactivity of 5-fluoro-2′-deoxyuridine prodrugs esterified at the 3′ and 5′ positions with several acyl groups has been investigated. The enzymatic reactivity was affected by the acyl structure, the site of esterification, and the number of esters in the prodrug molecule.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015972214747
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