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  • Polymer and Materials Science  (3)
  • 6-thioguanine  (2)
  • Carboplatin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Phase II trial of edatrexate plus carboplatin in metastatic non-small-cell lung cancer: a Southwest Oncology Group study (1997)
    Springer
    Cancer chemotherapy and pharmacology 41 (1997), S. 75-78 
    Details
    ISSN: 1432-0843
    Keywords: Key words Edatrexate ; Carboplatin ; Non-small-cell lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Edatrexate and carboplatin are each active single agents in the treatment of non-small-cell lung cancer (NSCLC). Preclinical studies in NSCLC lines have demonstrated schedule-dependent synergy of edatrexate followed by carboplatin. In a phase I trial, we demonstrated the tolerability of this combination, the ability of ice-chip cryotherapy to ameliorate dose-limiting mucositis, and promising activity in NSCLC. This phase II trial (SWOG 9207) was undertaken to investigate the efficacy of this regimen in stage IV NSCLC. Methods: A total of 24 patients with stage IV disease were accrued to this Southwest Oncology Group (SWOG) multicenter study. Treatment consisted of edatrexate 80 mg/m2 (50% dose on day 8) intravenously weekly for 5 weeks, then every other week, and carboplatin 350 mg/m2 every 28 days. Results: Of the 24 patients, 23 were assessable for toxicity and response; one was ineligible for study entry. Myelosuppression was the most significant toxicity; grade 3–4 neutropenia was seen in 8/23 patients. Two patients died of neutropenic sepsis during the first cycle of therapy, in both instances associated with the presence of pleural effusions. Although mild mucositis was common, it was dose-limiting (grade 3) in only three patients. Objective response was observed in 3/23 patients (13%). The median survival time was 7 months, and 30% of patients remained alive at one year. Conclusions: This study suggests that ice-chip cryotherapy is effective in reducing the severity of mucositis typically associated with this edatrexate schedule of administration. However, unexpectedly severe myelosuppression resulted in death from neutropenic sepsis in two patients with third space fluid collections, leading to a protocol amendment to exclude such patients from study entry. Furthermore, response and median survival with this dose schedule of edatrexate and carboplatin do not appear to be improved compared to other chemotherapeutic regimens tested by SWOG in this patient population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050710
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Phase II trial of 6-thioguanine administered as 120 hour continuous infusion for refractory or recurrent small cell lung cancer (1993)
    Springer
    Investigational new drugs 11 (1993), S. 81-83 
    Details
    ISSN: 1573-0646
    Keywords: 6-thioguanine ; phase II ; small cell lung cancer ; chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Nineteen eligible patients with recurrent small cell lung cancer were treated with a 120 hour continuous infusion of 6-thioquanine at a starting dose of 35 mg/m2/day. There were no responses in these 19 patients. Toxicity was acceptable with the primary toxicity being hematologic. Based on this trial, 6-thioquanine is not felt to have significant antitumor activity in this patient population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873917
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A phase II study of intravenous 6-thioguanine (NSC-752) in multiple myeloma (1990)
    Springer
    Investigational new drugs 8 (1990), S. S83 
    Details
    ISSN: 1573-0646
    Keywords: 6-thioguanine ; phase II ; multiple myeloma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Thirty-three patients with relapsing or refractory multiple myeloma were treated with 6-Thioguanine (6TG) at a dose of lg/M2, with therapy given over four hours every three weeks. The major toxicity seen was myelotoxicity; thrombocytopenia was more commonly noted than neutropenia. One patient achieved a PR, two were clinically improved. 6TG in this short infusion schedule proved to be myelotoxic, but demonstrated little activity in previously treated myeloma patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171990
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ionic transport in a sulfonated polystyrene-polyethylene copolymer (1976)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 14 (1976), S. 1769-1787 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The conductivity of a grafted copolymer composed of 21% sulfonated polystyrene and 79% polyethylene has been investigated as a function of temperature and absorbed moisture for membranes containing the monovalent counterions H+, Li+, Na+, K+, Rb+, Cs, and Ag+. The mobility of Ag+ was measured directly in an experiment analogous to that used for the mobility of F-centers in alkali halides. The mobility and density of free counterions depend on the amount of absorbed water, but only the mobility and not the density of free counterions is a thermally activated process. Current is carried by both intrinsic counterions and, in samples containing absorbed water with greater than 1.5 V applied, by protonic carriers created when the absorbed water is electrolyzed. Thermal depolarization studies indicate that persistent polarization observed is the result of homogeneous volume polarization, due to the orientation of sulfonic acid side groups.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1976.180141004
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  • 5
    Electronic Resource
    Electronic Resource
    Semiconducting polymers, by Marian Kryszewski, PWN-Polish Scientific Publishers, Warszawa, Poland, 1980, 710 pp. No price given (1982)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 20 (1982), S. 137-138 
    Details
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1982.130200211
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Electrical conductivity of 1,3-di-(methoxyphosphonic acid)benzene polyelectrolytes (1972)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 10 (1972), S. 3447-3450 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1972.170101128
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    Paper (German National Licenses)
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