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  • 1
    Electronic Resource
    Electronic Resource
    The 26S-proteasome: regulation and substrate recognition (1997)
    Springer
    Molecular biology reports 24 (1997), S. 39-44 
    Details
    ISSN: 1573-4978
    Keywords: ATPase ; 26S proteasome ; programmed cell death ; regulators
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract There is extensive reprogramming of the ATPase regulators of the 26S proteasome before the programmed elimination of the abdominal intersegmental muscles (ISM) after eclosion in Manduca sexta [1]. This extensive ATPase reprogramming only occurs in ISM which are destined to die and not in flight muscle (FM). The MS73 ATPase also increases in the proleg retractor muscles which die at a developmentally different stage to ISM. The non-ATPase regulator S5a shows a similar increase to the ATPase regulators. We have cloned the Manduca SUG2 ATPase and shown that this ATPase is a component of the 26S proteasome. This ATPase shows a similar increase in concentration to the other ATPases in 26S proteasomes before muscle death. The SUG2 ATPase is also associated with other smaller complexes besides the 26S proteasome which act as activators of the 26S proteasome. Finally, in a yeast two-hybrid genetic screen we have identified a protein in human brain which interacts with the MS73 ATPase (and human S6). The interacting protein contains 6 ankyrin repeats and is co-immunoprecipitated with anti-MS73 antiserum after in vitro transcription/translation. The ankyrin repeat protein may interact with the MS73 ATPase as part of the substrate recognition process by the 26S proteasome. Many proteins degraded by the 26S proteasome contain ankyrin repeats, e.g. IkB and some cyclins: binding through ankyrin repeats to an ATPase regulator may complement protein ubiquitination and S5a binding as recognition signals by the 26S proteasome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006800522814
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  • 2
    Electronic Resource
    Electronic Resource
    Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6′ (TBP1) in different tissues and organisms (1999)
    Springer
    Molecular biology reports 26 (1999), S. 35-38 
    Details
    ISSN: 1573-4978
    Keywords: activator complex ; ATPase ; 26S proteasome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Each 19S regulator of the 26S proteasome contains six ATPase subunits as well as many (〉14) non-ATPase protein subunits. The ATPase subunits have been detected in other complexes which may regulate transcription and possibly other cellular processes. The S10b (yeast SUG2 or human p42) and the S6′ (TBP1) ATPases have been found in an activator complex (modulator) prepared from bovine red cells. We have identified and partially characterised a similar activator from different human tissues (from soluble extracts of human brain, placenta and human embryonic kidney cells) and an insect: an activator is present in soluble extracts of abdominal intersegmental muscle from Manduca sexta. Activation is ATP and concentration dependent. There is no stimulation of human red cell-derived 20S proteasome by the Manduca activator ruling out 11S regulator in the preparations. Additionally, cross-species activation occurs: the Manduca activator increases the activity of rat skeletal muscle 26S proteasomes and the human placental activator similarly increases the activity of 26S proteasomes prepared from muscles from Manduca sexta. Finally, there is no evidence for other ATPases in the activator complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006903903534
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  • 3
    Electronic Resource
    Electronic Resource
    Siebenter Bericht der Deutschen Atomgewichts-Kommission (1927)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 160 (1927), S. 1-4 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19271600102
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  • 4
    Electronic Resource
    Electronic Resource
    Dynamics of the free rise of a light solid sphere in liquid (1996)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 1789-1792 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690420630
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  • 5
    Electronic Resource
    Electronic Resource
    Fermentation kinetics of spent sulfite liquor by Saccharomyces cerevisiae (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 28 (1986), S. 944-951 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The growth kinetics of the yeast Saccharomyces cerevisiae and the production rate of ethanol have been studied in batch fermentation under anaerobic conditions in a 20-L fermentor. Two substrates were used in fermentation trials: a synthetic mixture of three fermentable sugars, D-glucose, D-mannose, and D-galactose, and a low-yield liquor originating from a bisulfite cooking process. The Monod model adequately described the system in relation to the specific growth rate μx and the specific product formation rate μP. Different fermentation parameters (growth rate, substrate utilization, and product formation) were determined for the synthetic mixture and the bisulfite liquor. It was observed that the specific growth rate is much lower in spent sulfite liquor than in a synthetic medium. However, the specific product formation rate remains the same in both media.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260280703
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  • 6
    Electronic Resource
    Electronic Resource
    Winter, J. H: Chemische Syntheseplanung in Forschung und Industrie. 215 S., 43 abb., 16,5 × 24cm Berlin-Heidelberg-New York: Springer -Verlag 1982. Pappe, 18,80DM (1983)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 325 (1983), S. 525-525 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19833250327
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  • 7
    Electronic Resource
    Electronic Resource
    Dithiocarbonsäuren, Dithiocarbonsäureester oder Thiocarbonsäureamide aus methylenaktiven Chlormethylverbindungen und Schwefel (1989)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 331 (1989), S. 243-262 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dithiocarboxylic Acids, Dithiocarboxylic Esters, or Thiocarboxylic Amides by Reaction of Methylene-active Chloromethyl Compounds with SulfurWith a mixture of sulfur and amine in DMF at room temperature halomethyl compounds (1, 5-10) can be oxidized to give thiocarboxylic acids (2, 11-16) and their derivatives (3, 4, 17-35). We studied this reaction in detail especially with chloroacetic derivatives (11-15) or chloromethyl heterocycles (16) formally derived from chloroacetic acid.The resulting thiooxalic acid derivatives (11-27) represent activated acids and very useful C2-synthons, especially for the synthesis of heterocycles.Oxidation in the presence of triethyl amine leads to dithiocarboxylates (11-16) which can be alkylated to dithioesters (17-27) in high yields.As a rule, with different primary and secondary amines instead of tertiary amines these dithiocarboxylates or dithiocarboxylic esters can be transformed already at low temperatures to thioamides (28-35).
    Additional Material: 14 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19893310211
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  • 8
    Electronic Resource
    Electronic Resource
    1,3,4-Thiadiazole durch Umsetzung von Dithioestern mit KohlensäurehydrazidenHerrn Professor Schulz zum 60. Geburtstag gewidmet (1990)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 332 (1990), S. 55-64 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1,3,4-Thiadiazoles by Reaction of Dithiocarboxylic Esters with Carbonic Hydrazides1,1-Dithiooxalic esters 1 and heteroaryl dithiocarboxylic esters 2 react with carbonic hydrazides yielding 1,3,4-thiadiazoles. The 1-thiooxamoyl semicarbazides 3 or 1-heteroylthiocarbonyl semicarbazides 4, primarily formed by thioacylation of semicarbazide, where isolated. By cyclocondensation they yield 1,3,4-thiadiazole-2(3 H) ones 5, 6, or in the presence of acetic anhydride 3-acetyl-1,3,4-thiadiazol-2-ones- 7, 8, respectively.2-Amino- or 2-methylthio-1,3,4-thiadiazoles 11, 12 or 13, 14 are formed by reaction of the dithioesters 1, 2 with thiosemicarbazide or methyl dithiocarbazinate. By this way 1,3,4-thiadiazoles with heteroaryl- or carbamoylresidues in position 5 where synthesized for the first time.
    Additional Material: 8 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19903320107
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  • 9
    Electronic Resource
    Electronic Resource
    Hauptmann, S., Graefe, J.; Remane, H.: Lehrbuch der organischen Chemie. 2. Aufl. 797S., 122 Abb., 58 Tab., 16,7×24 cm. Leipzig: VEB Deutscher Verlag für Grundstoffindustrie 1980. Kunstleder, 52,50 M (1983)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 325 (1983), S. 174-174 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19833250125
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  • 10
    Electronic Resource
    Electronic Resource
    Synthese und spektrale Charakterisierung von blauen Benzenazofarbstoffen (1986)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 328 (1986), S. 497-514 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis and Spectral Characterization of Blue Azo Dyes of the Benzene Series53 Donor-acceptor substituted azo dyes of the benzene series were prepared by diazonium-coupling reactions (1 a-s) or halogen-cyanide exchange (→2 a-x, 3 a-j). Described are the preparation of the amines 4 a-m and the coupling compounds 5 a-t and the procedure of diazotizing and coupling.The colouristic and spectroscopic data show that compounds of the general formula 1 are excellent brilliant blue azo dyes useful for dyeing polyester material.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19863280406
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