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  • Acetylator phenotype  (1)
  • COLON CANCER  (1)
  • Chemistry  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Acetylator polymorphism in rheumatoid arthritis (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 279-281 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Rheumatoid arthritis ; Acetylator phenotype ; polymorphism ; sulphamethazine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Acetylator phenotype has been determined with sulphamethazine (sulphadimidine) in 69 Spanish patients with rheumatoid arthritis (48 females), all of whom were on second line therapy, and in 96 age-matched normal controls (54 females). Thirty-two patients (46.4%) and 56 controls (58.3%) were classified as slow acetylators. On analysing separately the females in both groups, 37.5% of patients and 63% of controls were found to be slow acetylators. No difference was found in the males (patients 66.3% and controls 52.4% slow acetylators). Rapid acetylator phenotype may be a risk factor for the development of severe rheumatoid arthritis in women.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00315397
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Colitis and Colon Cancer in Cotton-Top Tamarins (Saguinus oedipus oedipus ) Living Wild in Their Natural Habitat (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 1443-1453 
    Details
    ISSN: 1573-2568
    Schlagwort(e): COLITIS ; INFLAMMATION ; INFLAMMATORY BOWEL DISEASE ; COLON CANCER ; COLORECTAL CANCER ; NONHUMAN PRIMATE ; COTTON-TOP TAMARIN
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The cotton-top tamarin is a nonhuman primate noted for susceptibility to juvenile onset colitis and subsequent colon cancer. About 80% develop colitis in captive environments outside the tropics. The aim was to determine the prevalence of colitis and colorectal cancer in tamarins living wild in their tropical habitat. Endoscopic biopsy was used to compare severity of colitis, inflammatory/immune cell densities, mucosal dysplasia, and occurrence of cancer in wild tamarins in a tropical habitat with tamarins living captive in a temperate climate. Six colon biopsies from each of 69 captives showed severe colitis in 64.5% of biopsies and moderate colitis in 19.5% . Severe colitis was not found in 88 wild tamarins; 13% had moderate colitis. Densities of polymorphonuclear leukocytes, plasma cells, and mononuclear cells in the lamina propria were related directly to the severity of four grades of colitis (normal, mild, moderate, and severe). Histologic or gross signs of carcinoma were detected in 12 captives and low- or high-grade dysplasia in 15. Neither cancer nor dysplasia was found in any of the wild tamarins. The observations suggest that colitis and cancer in the tamarin model are linked to environmental factors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018842210330
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Dielectric relaxation studies on polymeric salts: Poly(methylmethacrylate-co-N,N-dimethylaminopropyl-acrylamide) benzoic acid systems (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Polymer International 40 (1996), S. 87-92 
    Details
    ISSN: 0959-8103
    Schlagwort(e): polymeric salts ; dielectric relaxation ; ionic conductivity ; ion conduction mechanism ; Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: A series of polymeric salts of p-substituted benzoic acids in poly(methylmethacrylate-co-N,N-dimethylaminopropylacrylamide) were prepared and AC impedance studies of film-attached electrodes were carried out. The impedance curves and conductivity variation with temperature were analysed. The parameter which describes the shape of the circular arcs in the impedance curves was temperature independent, and the distribution of relaxation times remained constant during the test on the material. Furthermore, the ionic conductivity was highly dependent on the chemical structure produced by the substituted benzoic group.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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