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  • Acetylator phenotype  (1)
  • Micellar liquid chromatography  (1)
  • polymorphism  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 45 (1993), S. 279-281 
    ISSN: 1432-1041
    Keywords: Rheumatoid arthritis ; Acetylator phenotype ; polymorphism ; sulphamethazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetylator phenotype has been determined with sulphamethazine (sulphadimidine) in 69 Spanish patients with rheumatoid arthritis (48 females), all of whom were on second line therapy, and in 96 age-matched normal controls (54 females). Thirty-two patients (46.4%) and 56 controls (58.3%) were classified as slow acetylators. On analysing separately the females in both groups, 37.5% of patients and 63% of controls were found to be slow acetylators. No difference was found in the males (patients 66.3% and controls 52.4% slow acetylators). Rapid acetylator phenotype may be a risk factor for the development of severe rheumatoid arthritis in women.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Micellar liquid chromatography ; Diethyldithiocarbamates ; Metal complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary This paper presents the, chromatographic retention of Co(II), Ni(II) and Cu(II) as diethyldithiocarbamate complexes in the presence of hexadecyltrimethylammonium bromide/ethanol/water systems, as mobile phase, by reversed phase high performance liquid chromatography. The presence of an organic modifier reduces the retention times and improves the efficiency. In order to evaluate the interaction between the metal complexes and the mixed micellar system the values of solute binding constants are calculated in, two ways: a) Arunyanart and Cline-Love's treatment and b) multiple regression analysis taking account of the ethanol percentages.
    Type of Medium: Electronic Resource
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