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  • Gastric Secretion  (5)
  • Acid Secretion  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 170-176 
    ISSN: 1432-1912
    Keywords: Chicken ; Acid Secretion ; Histamine ; Gastrin ; Carbachol ; Huhn ; Säuresekretion ; Histamin ; Gastrin ; Carbachol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The effect of histamine, carbachol, pentagastrin and gastrin extracts of different organs (glandular stomach, gizzard, duodenum) on gastric acid secretion was investigated in unanaesthetized chickens with a gastric fistula. 2. On a molar basis, pentagastrin was three times as potent as carbachol and 12 times as potent as histamine. The dose of pentagastrin required for stimulation of gastric secretion in chickens was very much higher than in mammals. 3. Extracts from the glandular stomach, the gizzard and the duodenum were free from acid secretion stimulating activity. 4. It was concluded that gastric acid secretion in chickens is controlled by a mechanism other than gastrin.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 259 (1968), S. 419-426 
    ISSN: 1432-1912
    Keywords: Cats ; Vagus ; Gastrin ; Gastric Secretion ; Katzen ; Gastrin ; Vagus ; Magensekretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die Wirkung des gastrin-analogen Tetrapeptidamids Try.Met.Asp.Phe-NH2 und von elektrischen Vagusreizen auf die Magensekretion von anaesthesierten Katzen mit einer Magenfistel wurde untersucht. 2. Das Tetrapeptid verursachte in Dosen von 0,1–3,2 μg/min i.v. nur eine Sekretion von pepsinarmem Magensaft. 3. Auf elektrischen Vagusreiz wurden große Mengen Magensaft und Pepsin sezerniert. 4. Bei den Katzen mit gekreuztem Kreislauf wurden mit dem Magensaft der gereizten Tiere große Mengen Pepsin ausgeschieden, während der Magensaft der nicht gereizten Tiere nur geringe Mengen Pepsin enthielt. 5. Aus den Versuchen wurde geschlossen, daß durch Vagusreizung Gastrin freigesetzt wird, welches als zirkulierendes Hormon die Säuresekretion stimuliert, und daß die Pepsin-Sekretion durch das bei Vagusreizung freigesetzte Acetylcholin verursacht wird.
    Notes: Summary 1. The effect was studied of the gastrin-analogue tetrapeptide amide Try.Met.Asp.Phe-NH2 and electrical vagus stimulation on gastric secretion in anaesthetized gastric fistula cats. 2. The tetrapeptide in doses of 0.1–3.2 μg/min i.v. stimulated the secretion of gastric juice containing only small amounts of pepsin. 3. Electrical vagus stimulation provoked the secretion of large amounts of gastric juice and pepsin. 4. In pairs of cross circulated cats the gastric juice of the vagus stimulated animals contained much pepsin, the gastric juice of the not stimulated animals did not. 5. It was concluded from these results that gastrin was released by vagal excitation and stimulated as a circulating hormone acid secretion and that pepsin secretion was stimulated by a vagal release of acetylcholine.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 271 (1971), S. 142-148 
    ISSN: 1432-1912
    Keywords: Chicken ; Crop ; Acid Secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The contribution of the crop to gastric acid secretion was investigated in unanaesthetized chickens with a gastric fistula. 2. Basal secretion was enhanced by removal or distension of the crop and reduced by irrigating the crop with food suspension, acetylcholine, glycine or propyl alcohol as compared with phosphate buffer. 3. It was concluded that the crop is able to release stimulating and inhibiting impulses towards the glandular stomach. The stimulating impulses were elicited by mechanical, the inhibiting ones by chemical excitation.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 271 (1971), S. 149-156 
    ISSN: 1432-1912
    Keywords: Gastric Acid Stimulants ; Carboxyl-labelled Histidine ; 14C-Co2-Expiration ; Gastric Secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The effects of gastrin I, bethanechol, histamine and reserpine on gastric acid secretion and the expiration of radioactive carbon dioxide have been studied in anaesthetized carboxyl-14C-l-histidine-loaded rats. 2. All compounds tested stimulated gastric acid secretion. In unstimulated animals the radioactive carbon dioxide in the expired air dropped exponentially with time; it was increased by reserpine and histamine, but not by gastrin and bethanechol. 3. In gastrin- and histamine-treated animals acetazolamide suppressed gastric acid secretion as well as the expiration of radioactive carbon dioxide. 4. The effect of histamine on the expiration of radioactive carbon dioxide can be attributed to effects other than the enhanced decarboxylation of histidine. The response to reserpine can be explained as an activation of histidine decarboxylase. Whether the failure of gastrin I and bethanechol to increase the expiration of radioactive carbon dioxide documents their inability to stimulate histidine decarboxylase in vivo, cannot be decided.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 272 (1972), S. 117-120 
    ISSN: 1432-1912
    Keywords: Gastric Secretion ; Bethanechol ; Histamine ; Phloxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of phloxin (Na salt of tetrabromo-tetrachlorofluorescein) on histamine- and bethanechol-stimulated gastric acid secretion was studied in anaesthetized rats. Concentrations of phloxin, equimolar with those of the stimulants, depressed the secretory response to histamine and had no influence on the bethanechol effect. The results suggest that histamine is not involved in the events triggered by bethanechol which stimulate gastric acid secretion in rats.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 283 (1974), S. 83-92 
    ISSN: 1432-1912
    Keywords: Pig ; Gastric Secretion ; Histamine ; Carbachol ; Pentagastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gastric acid secretion was studied in 5 miniature pigs provided with a chronic gastric fistula. Basal secretion did not change during the growth of the animals. Histamine, carbachol, and pentagastrin produced a dose-dependent volume and acid response. The highest peak acid output (PAO) was achieved with histamine. The maximal peak volume output after histamine was only exceeded by carbachol which was due to an excessive salivation. The maximal PAO after carbachol and pentagastrin as well as the maximal peak volume output after pentagastrin were very low. The poor secretory responses to carbachol and pentagastrin are discussed in the light of possible inhibitory mechanisms or of drug-receptor-interactions.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 273 (1972), S. 219-229 
    ISSN: 1432-1912
    Keywords: Inhibition ; Chickens ; Gastric Secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In unanaesthetized gastric fistula chickens the effect on gastric acid secretion was studied of atropine, insulin and 2-deoxy-D-glucose (2-DG). 2. The basal secretion of H+ was diminished by insulin and 2-DG. The concentration of H+ was reduced by insulin, but not by 2-DG suggesting a less stronger effect of 2-DG on volume than on H+ secretion. 3. The histamine stimulated secretion was inhibited competitively by atropine and noncompetitively by insulin and 2-DG. The inhibiting action of atropine on pentagastrin stimulated secretion was also of a competitive type; whether or not insulin and 2-DG inhibited pentagastrin noncompetitively could not be clearly decided. 4. The inhibiting actions are discussed in the light of mechanism concerning the glucose metabolism in mammals. It is concluded that in chickens the control of gastric secretion differs considerably from that of mamals.
    Type of Medium: Electronic Resource
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