ISSN:
1432-1912
Keywords:
Pig
;
Gastric Secretion
;
Histamine
;
Carbachol
;
Pentagastrin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Gastric acid secretion was studied in 5 miniature pigs provided with a chronic gastric fistula. Basal secretion did not change during the growth of the animals. Histamine, carbachol, and pentagastrin produced a dose-dependent volume and acid response. The highest peak acid output (PAO) was achieved with histamine. The maximal peak volume output after histamine was only exceeded by carbachol which was due to an excessive salivation. The maximal PAO after carbachol and pentagastrin as well as the maximal peak volume output after pentagastrin were very low. The poor secretory responses to carbachol and pentagastrin are discussed in the light of possible inhibitory mechanisms or of drug-receptor-interactions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500147
