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  • 1
    Electronic Resource
    Electronic Resource
    Formation and propagation of brain oedema fluid around human brain metastases. A CT study (1988)
    Springer
    Acta neurochirurgica 90 (1988), S. 35-41 
    Details
    ISSN: 0942-0940
    Keywords: Brain oedema ; brain tumours ; oedema formation ; oedema propagation ; dexamethasone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Computerized tomography (CT) was used to examine the timecourse of the propagation of extravasated contrast medium from small brain metastases into the peritumoural oedematous white matter, following infusion of 200 ml of meglumine amidtrizoate for 3 hours. Four patients with a metastatic brain tumour were examined. CT scans at identical levels were taken 1.5, 3, 6, 9, and 12 hours after start of contrast infusion. Following 4–7 days of dexamethasone treatment (8–12mg/day i.v.) the examination was repeated. A contrast-enhanced area was observed surrounding the clearly delineated tumours, expanding gradually in a circular fashion into the peritumoural white matter oedema. The expanding circular enhancement was measured planimetrically on the various scans. From these values, the increase in radius/hr respectively in volume/hr was calculated, assuming a spherical geometry. This enabled a determination of the rate of oedema fluid formation and of the speed of oedema fluid propagation. The formation rate of oedema fluid amounted to 0.5–3.2ml/hour and the speed of oedema fluid spreading to 1.9 mm/hour. Following treatment with dexamethasone the formation rate of oedema fluid is reduced by 30–50%. The important clinical implications of these new findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541264
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Angiographic diagnosis of acoustic neurinomas and meningiomas in the cerebellopontine angle—A reappraisal (1980)
    Springer
    Neuroradiology 19 (1980), S. 73-80 
    Details
    ISSN: 1432-1920
    Keywords: Brain neoplasm ; Acoustic neurinoma ; Meningioma ; Cerebellopontine angle ; Neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-two acoustic neurinomas and seven meningiomas in the cerebellopontine angle were reviewed, and the radiological differential diagnosis of these tumors is discussed. Though enlarged internal auditory meati and characteristic CT findings were reasonably reliable indicators for the diagnosis of acoustic neurinomas, it was angiography which substantiated their correct diagnosis. An arcuate vein was frequently demonstrated with acoustic neurinomas, but never with meningiomas. Visualization of tangled veins seems to favor a diagnosis of acoustic neurinomas. Contrary to earlier reports, tumor stains were most frequently visualized using selective external carotid arteriography. The degree of tumor stains did not aid in differentiating acoustic neurinomas from meningiomas. The importance of using angiotomography, especially in the anteroposterior projection, and external carotid angiography during prolonged injections of large amounts of contrast media, is emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342598
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Co-expression and inheritance of foreign genes in transformants obtained by direct DNA transformation of tobacco protoplasts (1986)
    Springer
    Molecular genetics and genomics 205 (1986), S. 1-8 
    Details
    ISSN: 1617-4623
    Keywords: Nicotiana tabacum ; Protoplasts ; DNA transformation ; APH(3′)II ; Nopaline synthase ; Inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A plasmid containing two marker genes for expression in plants was constructed. This 16 kb vector, pCT1T3, contains an intact nopaline synthase gene and a chimaeric gene consisting of the promoter and terminator regions from cauliflower mosaic virus gene VI and a structural gene, aminoglycoside phosphotransferase (APH(3′)II), from the bacterial transposon Tn5. After transformation of tobacco mesophyll protoplasts with this plasmid, several kanamycin-resistant transformants were obtained. Intensive studies on the drug tolerance of growth and differentiation of the transformants showed that the chimaeric gene was stably expressed. Of 17 independent transformants, 3 (about 18%) expressed the two marker genes, regardless of the state of differentiation, as did individual plants regenerated from the same callus. Multiple copies of the inserted DNA were found in some transformants. Viable seeds were produced by 12 out of 15 independent transformants. Seeds obtained by self-pollination were germinated on medium containing kanamycin sulphate. With the exception of one clone, resistant seedlings with green leaves and sensitive seedlings with white leaves were found to segregate in a 3:1 ratio. This suggests that the inheritance of the inserted gene is Mendelian. A reciprocal cross between the transformants and wild-type tobacco also showed nuclear transmission of the APH(3′)II gene. This was consistently maintained in a subclone of the same transformant derived from the same callus line. Stable inheritance of the single dominant character was also seen among seeds formed in several different flower pods of the same individual plants. Two clones were also found to synthesize nopaline in addition to expressing APH(3′)II. Analysis of the progeny obtained by self-crosses of such transformants revealed the simultaneous expression of these two enzymes, indicating that the two marker genes are linked on the same chromosome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02428025
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    Paper (German National Licenses)
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