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  • 1
    Electronic Resource
    Electronic Resource
    Fluorescence energy transfers in labelled G-actin and F-actin
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 786 (1984), S. 188-196 
    Details
    ISSN: 0167-4838
    Keywords: Actin ; Actomyosin ; Fluorescence energy transfer ; Nucleotide-binding site
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(84)90088-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of metabolic factors and blood pressure on kidney function in proteinuric Type 2 (non-insulin-dependent) diabetic patients (1993)
    Springer
    Diabetologia 36 (1993), S. 1051-1056 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic nephropathy ; Type 2 (non-insulin-dependent) diabetes mellitus ; proteinuria ; lipids ; blood pressure ; metabolic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Decline of kidney function with time and its influencing factors were investigated in the present longitudinal study in Type 2 (non-insulin-dependent) diabetic patients with clinical diabetic nephropathy. Compared to a control group of Type 2 diabetic patients without proteinuria, the proteinuric patients showed a higher prevalence of hypertension, higher systolic blood pressure values and serum triglyceride levels. The annual loss of glomerular kidney function was much higher in the proteinuric patients (5.3 ml·min−1·1.73 m2) than in the control subjects (0.9 ml·min−1·1.73 m2). Correlation analyses revealed a close correlation between the annual decrease of kidney function and the factors, systolic and diastolic blood pressure, triglyceride and postprandial blood glucose level as well as body mass index. Regression analyses showed for the first time that in addition to the systolic blood pressure and metabolic control, the triglyceride level is also an independent factor influencing the progression of nephropathy. Higher values of these parameters were associated with a more rapid deterioration of kidney function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02374498
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Blood pressure and metabolic control as risk factors for nephropathy in Type 1 (insulin-dependent) diabetes (1985)
    Springer
    Diabetologia 28 (1985), S. 6-11 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; diabetic nephropathy ; blood pressure ; metabolic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The respective rôles of arterial blood pressure and metabolic control in different stages of diabetic nephropathy were analyzed retrospectively in 52 sequentially-followed Type 1 (insulin-dependent) diabetic patients. A negative correlation was found between median post-prandial blood glucose and median duration of diabetes until onset of persistent proteinuria (p〈0.01). Systolic blood pressure was higher in patients who subsequently developed persistent proteinuria than those who did not (140 versus 121 mmHg; p〈0.05), but duration of the interval until onset of persistent proteinuria was not related to blood pressure. After onset of persistent proteinuria, hypertensive diabetic patients developed elevated serum creatinine concentrations more frequently than normotensive diabetic patients (67% versus 14%, p〈0.05). In these patients, the delay until elevation of serum creatinine concentration was negatively correlated with blood glucose (p〈0.01). Once serum creatinine was raised, decay of renal function occurred faster in patients with persistent than intermittent hypertension (p〈0.05). No effect of metabolic control was demonstrable at this stage of nephropathy. It is concluded that metabolic control determines the early course of diabetic nephropathy, whereas blood pressure is more important in advanced stages of nephropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276992
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    Paper (German National Licenses)
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