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  • 1
    Electronic Resource
    Electronic Resource
    Regional cerebral blood flow of acute carbon monoxide poisoning in cats (1987)
    Springer
    Acta neuropathologica 72 (1987), S. 389-393 
    Details
    ISSN: 1432-0533
    Keywords: Regional cerebral blood flow ; Carbon monoxide ; Acute carbon monoxide poisoning ; Selective vulnerability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of selective vulnerability of the cerebral white matter and pallidum in acute carbon monoxide (CO) poisoning was experimentally investigated by measuring regional cerebral blood flow (rCBF) with the iodo-[14C]antipyrine method. A CO group consisting of five cats was exposed to 0.2%–0.3% CO gas and the rCBF was measured when moderate systemic hypotension (70–80 mm Hg) occurred; because systemic hypotension of this level during exposing to 0.2%–0.3% CO gas induces typical cerebral lesions of acute CO poisoning in almost all cats [Okeda et al. Acta Neuropathol (Berl) 54:1–10 (1981)]. Controls were a hypotension group of three cats with moderate systemic hypotension induced for 1 h without CO exposure, and a control group of five cats which inhaled only air for 2 h. The rCBF of each structure in the CO and hypotension groups was evaluated as a percentage of that of the control group. The rCBF of the CO group exhibited a wide range (68%–127%) according to the structures examined, and the mean (94.6%) was large compared with that (range: 53%–82%, mean: 67.4%) of the hypotension group. In the CO group, the examined brain structures where divided in two group according to the rCBF values; low-value structures and high-value structures. There was significant (P〈0.05) difference between rCBFs of both the structure groups. The cerebral white matter and pallidum belonged to low-value structures, and these rCBFs did not show any significant difference from those of other structures in this structure group. The rCBF of the cerebral white matter was significantly lower than that of the cerebellar white matter. From these findings and our previous observations using the hydrogen clearance and rheological methods, the mechanism of the selective vulnerability of the pallidum and cerebral white matter in acute CO poisoning is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687271
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Deletion of a large genomic segment in tobacco varieties that are resistant to potato virus Y (PVY) (1999)
    Springer
    Molecular genetics and genomics 262 (1999), S. 822-829 
    Details
    ISSN: 1617-4623
    Keywords: Key words Recessive resistance ; Potato virus Y ; Randomly amplified polymorphic DNA (RAPD) ; Nicotiana tabacum L.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Recessive alleles (va, va 1 , va 2 , etc) of the tobacco Va locus confer resistance to potato virus Y (PVY). To elucidate the mechanism underlying this resistance, we attempted to identify randomly amplified polymorphic (RAPD) markers that reveal polymorphism between two nearly isogenic lines (NILs) that differ in their susceptibility to PVY. Using each of 500 primers and 800 pairs of primers, we identified over 100 RAPD fragments that differed between the NILs. We applied these RAPD primers or primer combinations to an F2 population obtained from a cross between the susceptible line BY4 and the resistant va 2 -bearing NIL, F55. It was found that only 10 RAPD markers were polymorphic between resistant and susceptible plants. Unexpectedly, these markers were all linked to Va. All 10 RAPD markers were present in all 8 susceptible varieties tested. At least one RAPD marker was not detected in 8 out of 10 resistant varieties. Southern analysis revealed that the sequences of markers were not present in the genomes of resistant varieties, and the markers were found in individually distinct positions on the chromosomes of susceptible tobacco varieties. These results strongly suggest that the resistance conferred by va is due to deletions at the Va locus governing susceptibility to PVY.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051146
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    Paper (German National Licenses)
    Fulltext
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