ISSN:
1432-1440
Keywords:
Acute myocardial infarction
;
Myosin light chains
;
CK-MB-isoenzyme
;
Left ventricular function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Infarct size can be estimated noninvasively by analysis of circulating CK-MB and/or cardiac myosin light chains. To investigate whether myosin light chains release is correlated with the impairment of left ventricular function in acute myocardial infarction, this marker protein was determined by liquid phase radioimmunoassay in serial blood samples of 25 patients. Likewise CK-MB was measured in the same blood samples. From the serum concentration changes the cumulative appearance was calculated as an estimate of infarct size. Left ventricular enddiastolic pressure, global and regional ejection fraction were measured immediately and 3 weeks after admission. Particularily during the chronic phase of myocardial infarction a close correlation was found between serological estimates of infarct size and impairment of left ventricular function. The cumulative appearance of myosin light chains was superior to CKMB in assessing the hemodynamic impact of myocardial infarction in the acute and chronic stage. Therefore, myosin light chains are an appropriate serological indicator for the hemodynamic significance of myocardial infarction during the acute and chronic stage and might allow an assessment of the patients' risk.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01726579
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