ISSN:
1430-3418
Keywords:
Neutrophils
;
Monocyte
;
Actin
;
Locomotion
;
Adhesion
;
Glucocorticoids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract A monocyte-derived steroid-induced factor has been shown previously to induce dispersive locomotion in human neutrophils and to lower adhesion to an albumin-coated glass surface. In this paper we show that this factor inhibits adhesion of neutrophils to bovine aorta and human endothelial cells by an undetermined mechanism. It induces unique changes in neutrophil shape with a characteristic monopolar pattern of F-actin distribution, which may correlate with the dispersive locomotion observed in the absence of a concentration gradient. This factor also inhibits N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of neutrophils in a modified Boyden chamber assay. The reduction of adhesion and the inhibition of chemotaxis by the factor in vitro indicate a possible in vivo anti-inflammatory role.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s00898-997-0007-6
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