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  • 1
    ISSN: 1432-1440
    Keywords: Adriamycin ; Lungentumoren ; in vivo- in vitro Korrelation ; Adriamycin ; Lung carcinoma ; In vivo-in vitro correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effect of 1.38×10−5 M adriamycin on tritiated uridine incorporation was studied after 3 hours treatment of suspensions of 25 advanced human lung carcinomas in vitro. The results were correlated with the responses to clinical therapy. All tumours which showed an inhibition of uridine incorporation in vitro of more than 40% were also sensitive to clinical treatment with adriamycin.
    Notes: Zusammenfassung Es wurde die Wirkung von 1,38×10−5 molar Adriamycin auf den 3H-Uridineinbau an Zellsuspensionen von 25 menschlichen Lungentumoren untersucht und mit dem Therapie-Erfolg in der Klinik in Beziehung gesetzt. Alle Tumoren mit einer Uridineinbauhemmung in vitro von mehr als 40% waren auch in der Klinik auf eine Behandlung mit Adriamycin sensibel.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5117
    Keywords: water quality ; assessment criteria ; biological hierarchy ; reference conditions ; MuLFA ; Austria ; Europe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We propose a multi-level concept for fish-based assessment (MuLFA) of the ecological integrity of running waters. This concept is designed for large-scale monitoring programmes such as required for the proposed Water Framework Directive of the EU. Out of five different biological organisation levels (fauna, community, guild, population and individual), we propose seven criteria: River-type-specific species, species with self-sustaining populations, fish region, number of guilds, guild composition, population size and population age structure. The principle of the MuLFA is based on assessing the deviation from undisturbed reference conditions. Reference conditions have to be compiled for every distinct river type using historical fish and abiotic data, present river-type-specific reference sites and reference models. The final assessment procedure is done by comparing the assessment reach with the reference conditions using a 5-tiered normative scheme and assigning that reach to the level of highest coincidence. The benefit of the MuLFA is its potential for consistent sensitivity to low- and high-dose human alterations, and due to its general character, its adaptability to all river types.
    Type of Medium: Electronic Resource
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