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  • 1
    Electronic Resource
    Electronic Resource
    Vereinfachte Methode zur Erfassung toxischer Effekte bei hämorrhagischen Zellsuspensionen (1970)
    Springer
    Annals of hematology 20 (1970), S. 377-382 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A simple method designed after theMans-Novellis procedure is decribed for measuring the incorporation of tritium-labelled precursors into hemorrhagic cell suspensions. It is suitable for clinical routine laboratories.
    Notes: Zusammenfassung Eine einfache Methode wird beschrieben, die es gestattet, an hämorrhagischen Zellsuspensionen (z. B. Blut, Knochenmarkpunktate, Höhlenergüsse) den Einbau radioaktiver Tritum-markierter Bausteine in Trichloressigsäureunlösliches Material schnell zu messen. Sie erscheint als klinische Routineuntersuchung für die Vortestung von Zytostatika brauchbar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01634048
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  • 2
    Electronic Resource
    Electronic Resource
    Schnellmethode zur Sensibilitätstestung maligner Tumoren gegenüber Cytostatica (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 374-376 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A rapid method is reported for testing the sensitivity of tumors to cancerostatic agents. The method was developed using solid tumors that were treated with hydroxyurea agents. The method may be performed within a few hours and should prove applicable for testing the sensitivity of human tumors to cancerostatic agents.
    Notes: Zusammenfassung Es wird eine Schnellmethode der Sensibilitätstestung von Tumoren beschrieben, die ihre Brauchbarkeit für solide Tiertumoren unter Einwirkung von Hydroxyharnstoff erwiesen hat. Sie ist innerhalb weniger Stunden durchführbar und dürfte sich auch in der Humanmedizin für die Testung der Empfindlichkeit bösartiger Geschwülste gegenüber Cytostatica eignen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484868
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical correlates of in vitro effect of adriamycin on advanced lung carcinoma (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 665-670 
    Details
    ISSN: 1432-1440
    Keywords: Adriamycin ; Lungentumoren ; in vivo- in vitro Korrelation ; Adriamycin ; Lung carcinoma ; In vivo-in vitro correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effect of 1.38×10−5 M adriamycin on tritiated uridine incorporation was studied after 3 hours treatment of suspensions of 25 advanced human lung carcinomas in vitro. The results were correlated with the responses to clinical therapy. All tumours which showed an inhibition of uridine incorporation in vitro of more than 40% were also sensitive to clinical treatment with adriamycin.
    Notes: Zusammenfassung Es wurde die Wirkung von 1,38×10−5 molar Adriamycin auf den 3H-Uridineinbau an Zellsuspensionen von 25 menschlichen Lungentumoren untersucht und mit dem Therapie-Erfolg in der Klinik in Beziehung gesetzt. Alle Tumoren mit einer Uridineinbauhemmung in vitro von mehr als 40% waren auch in der Klinik auf eine Behandlung mit Adriamycin sensibel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469146
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Sensibilitätstestung maligner menschlicher Tumoren gegenüber Cytostatica (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 219-223 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit einer früher beschriebenen in vitro-Schnellmethode (DNS-Synthese) zur Sensibilitätstestung wurden Gewebsproben von 21 operativ entfernten menschlichen Tumoren untersucht. Eine Testung gegenüber Trenimon, Methotrexat und Natulan in 3 Dosierungen zeigte, daß selbst Tumoren gleicher Lokalisation und gleicher Histologie unterschiedlich reagieren. Das bisher vorgelegte Material reicht zwar für eine statistische Sicherung nicht aus, dennoch scheint es, daß die beobachtete Individualität der Tumoren bei weiteren Untersuchungen gesichert werden kann. Dies würde bedeuten, daß eine Chemotherapie auch histologisch gleichartiger maligner Tumoren individualisiert werden muß.
    Notes: Summary Slices from 21 human tumors were obtained immediately after resection. The tissue samples were exposed to Trenimon, Methotrexat, and Natulan. The incorporation of3H-thymidine into the DNA of these slices was evaluated by a rapid and simple method described earlier. It could be demonstrated that all tumors, even those of a same origin and with the same histological features showed individual sensitivity against any one of these cytostatic drugs.—The findings presented here are not yet sufficient for statistical evaluation. If the individuality of every single tumor can be confirmed in further experiments, the chemotherapy of even histologically similar malignant tumors will have to be individual too.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01495986
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Sensibilitätstestung maligner menschlicher Tumoren gegenüber Cytostatica. II (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 196-198 
    Details
    ISSN: 1432-1440
    Keywords: Screening ; chemotherapy ; tumour ; DNA ; Sensibilitätstestung ; Chemotherapie ; Tumor ; DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit einer früher beschriebenen Methode zur Sensibilitätstestung (3H-Thymidineinbau, Flüssigkeitsscintillationsmessung) haben wir 30 menschliche Adenocarcinome (10 Rectum-Sigma-Carcinome, 10 Magen-Carcinome, 30 Mamma-Carcinome) gegenüber Trenimon®, Methotrexat® und Natulan® getestet und statistisch ausgewertet. Die in unserer früheren Untersuchung vermutete Individualität der Tumoren konnte bestätigt werden.
    Notes: Summary Using a sensibility testing method previously described by the authors (3H-thymidine incorporation, liquid scintillation counting), the sensitivity of 30 human tumours (10 recto-sigmoid carcinomas, 10 gastric carcinomas, 10 carcinomas of the breast) was tested in vitro against Trenimon®, Methotrexat® and Natulan®. The results obtained were evaluated statistically. Each tumour proved to react specifically to the agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487143
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  • 6
    Electronic Resource
    Electronic Resource
    Resistenztestung von menschlichen Tumoren im Kurzzeit-Test (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 579-580 
    Details
    ISSN: 1432-1440
    Keywords: In-vitro test ; human tumours ; proliferation ; resistance ; In-vitro-Test ; menschliche Tumoren ; Proliferation ; Resistenz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit einer früher beschriebenen Methode zur Sensibilitätstestung wurden verschiedene menschliche Tumoren in vitro untersucht. Im vorliegenden Test werden sowohl die Proliferation als auch die Resistenz von Tumoren gegenüber Cytostatica erfaßt.
    Notes: Summary Various human tumours have been investigated using, as previously described an in vitro method for sensitivity testing. This test provides information both on the rates of proliferation of tumours and on their resistance to cytostatic agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468903
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  • 7
    Electronic Resource
    Electronic Resource
    Albumin messenger RNA after partial hepatectomy and sham operation
    Amsterdam : Elsevier
    BBA Section Nucleic Acids And Protein Synthesis 610 (1980), S. 311-317 
    Details
    ISSN: 0005-2787
    Keywords: (Rat liver) ; Albumin ; Hepatectomy ; Regeneration ; mRNA, cDNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2787(80)90012-X
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  • 8
    Electronic Resource
    Electronic Resource
    Chalones and Cancer: Melanoma Regression induced by “Chalone”: a New Tumour Inhibiting Principle acting in vivo (1968)
    [s.l.] : Nature Publishing Group
    Nature 220 (1968), S. 138-139 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TISSUE-SPECIFIC anti-mitotic substances, now known as chalones1, have been extracted from a number of tissues, and especially well known are the epidermal and granule -cytic chalones2'3. Although it is tissue-specific the epidermal chalone is not species-specific4. The various chalones evidently ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/220138a0
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  • 9
    Electronic Resource
    Electronic Resource
    Spezifische hemmung der DNS-synthese von helazellen durch endometrium-extrakt
    Amsterdam : Elsevier
    Experimental Cell Research 59 (1970), S. 464-468 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(70)90655-5
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    12. Onkobiogramm und Krebs-Chemotherapie: Realität Oder Hoffnung? (1975)
    Springer
    Langenbeck's archives of surgery 339 (1975), S. 121-126 
    Details
    ISSN: 1435-2451
    Keywords: In-vitro Tests ; Tumors ; Proliferation ; Resistance ; In-vitro-Test ; Tumor ; Proliferation ; Resistenz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Auf Grund tierexperimenteller Untersuchungen wird belegt, daß Therapieergebnisse bei Tumoren mit in vitro-Testverfahren voraussagbar sind. Die Über-einstimmung zwischen bisherigen Testergebnissen and Therapieergebnissen beim Men schen sind zwar hoffnungsvoll, einen eindeutigen Nachweis können jedoch erst prospektive, statistisch auswertbare klinische Studien bringen. Zwei Erkenntnisse erhält man schon heute aus den Testergebnissen: Hinweise auf die Proliferationsrate, von der die Zytostatika-Wirkung abhängt, und Hinweise auf biochemisch bedingte Resistenzen.
    Notes: Summary On the basis of animal experiments it is shown that the results of tumor chemotherapy can be predicted with the aid of in-vitro test systems. In investigations carried out on human tumors, the correlations obtained between in-vitro test results and response to therapy are promising. However, definitive proof of a correlation can only be provided by planned, statistically supported clinical studies. Two types of information can already be obtained from the in-vitro tests: data concerning the rate of proliferation of the tumor, on which the activity of cytostatic agents depends, and data on certain types of resistance to cytostatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257499
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