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  • 1
    Electronic Resource
    Electronic Resource
    Adult-onset mixed myopathy with nemaline rods, minicores, and central cores: a muscle disorder mimicking polymyositis (1984)
    Springer
    Journal of neurology 231 (1984), S. 103-108 
    Details
    ISSN: 1432-1459
    Keywords: Adult-onset mixed myopathy ; Nemaline myopathy ; Minicore disease ; Central core disease ; Polymyositis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A woman, aged 75 years, presented with a 15-year history of progressive, generalized, painful muscle weakness and wasting. Clinical and laboratory investigation revealed a sporadic muscle disorder. Muscle biopsy showed a mixed pattern of nemaline myopathy with minicores and central cores and severe atrophy of type-1 and type-2 fibers. A trial of immunosuppressive treatment did not improve her condition, which clinically mimicked chronic progressive polymyositis. Mixed myofibrillar myopathies of this type have so far only been described among the group of congenital myopathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313674
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A comparative trial of anti-glycoconjugate antibody assays: IgM antibodies to GM1 (1994)
    Springer
    Journal of neurology 241 (1994), S. 475-480 
    Details
    ISSN: 1432-1459
    Keywords: Lower motor neuron syndrome ; Multifocal motor neuropathy ; Anti-ganglioside antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract IgM class antibodies against the ganglioside GM1 have been found in a subgroup of patients with lower motor neuron syndromes and multifocal motor neuropathies (MMN). The pathogenic relevance of these antibodies is still unclear, but some MMN patients with IgM antibodies against GM1 seem to profit from immunosuppressive therapy. A reliable test for IgM antibodies against GMl may be useful for identifying these patients. We have assessed the comparability of the ELISA tests used for the determination of IgM against GM1 by sending coded serum samples to nine laboratories. In three samples high-titre IgM antibodies against GM1 were detected by all laboratories. This result was confirmed by dot blot immunodetection and thin-layer chromatography immuno-overlay. Seven samples were read as negative by nearly all laboratories. Major discrepancies between laboratories were noted in the analysis of one sample with results ranging from negative to “high titre”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00919708
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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