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  • 1
    Electronic Resource
    Electronic Resource
    Giant axonal neuropathy: report on a case with focal fiber loss (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 543-546 
    Details
    ISSN: 1432-0533
    Keywords: Giant axonal neuropathy ; Intermediate filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on a 5 1/2 year-old boy with chronic progressive polynèuropathy, ataxia, and pyramidal signs. His hair was not curled. Sural nerve biopsy disclosed many axons enlarged by accumulation of 10-nm neurofilaments and a marked variability in the number of myelinated fibers as well as in the amount of axonal enlargements among different fascicles. These findings and the electrophysiological data were consistent with a giant axonal polyneuropathy with a multifocal fiber loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310034
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acute axonal idiopathic polyneuropathy: A Guillain-Barré syndrome variant? (1992)
    Springer
    Neurological sciences 13 (1992), S. 481-486 
    Details
    ISSN: 1590-3478
    Keywords: Guillain-Barré syndrome ; polyneuropathy ; axonal degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Descriviamo 7 casi di polineuropatia acuta che soddisfano i criteri diagnostici del NINDS (3). Lo studio elettrofisiologico e la biopsia di nervo surale (eseguita in due pazienti) hanno evidenziato un quadro di neuropatia con evidenti fenomeni di degenerazione assonale, ma senza segni di demielinizzazione. discutiamo se la neuropatia acuta assonale idiopatica appartiene allo spettro della sindrome di Guillain-Barré o costituisce una diversa entità clinico-patologica.
    Notes: Abstract We report 7 cases of acute polyneuropathy fitting the NINDS diagnostic criteria for GBS. Electrophysiological study and sural nerve biopsy revealed a picture of axonal polyneuropathy, without changes suggesting demyelination. We discuss whether the acute idiopathic axonal neuropathy belongs to the GBS spectrum or represents a separate clinico-pathological entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230868
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A comparative trial of anti-glycoconjugate antibody assays: IgM antibodies to GM1 (1994)
    Springer
    Journal of neurology 241 (1994), S. 475-480 
    Details
    ISSN: 1432-1459
    Keywords: Lower motor neuron syndrome ; Multifocal motor neuropathy ; Anti-ganglioside antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract IgM class antibodies against the ganglioside GM1 have been found in a subgroup of patients with lower motor neuron syndromes and multifocal motor neuropathies (MMN). The pathogenic relevance of these antibodies is still unclear, but some MMN patients with IgM antibodies against GM1 seem to profit from immunosuppressive therapy. A reliable test for IgM antibodies against GMl may be useful for identifying these patients. We have assessed the comparability of the ELISA tests used for the determination of IgM against GM1 by sending coded serum samples to nine laboratories. In three samples high-titre IgM antibodies against GM1 were detected by all laboratories. This result was confirmed by dot blot immunodetection and thin-layer chromatography immuno-overlay. Seven samples were read as negative by nearly all laboratories. Major discrepancies between laboratories were noted in the analysis of one sample with results ranging from negative to “high titre”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00919708
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    Paper (German National Licenses)
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