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  • 1
    Electronic Resource
    Electronic Resource
    Progressive supranuclear palsy with Lewy bodies (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 344-346 
    Details
    ISSN: 1432-0533
    Keywords: Progressive supranuclear palsy ; Lewy body ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case is reported which revealed not only clinical and neuropathological features of progressive supranuclear palsy, but also the presence of large numbers of Lewy bodies in the brain stem nuclei and cerebral cortex. This case seems to be progressive supranuclear palsy with Lewy bodies distributed as in Parkinson's disease. Such case has not been previously reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688061
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Anticoagulant therapy in recurrent cerebral embolism: a retrospective study in non-valvular atrial fibrillation (1988)
    Springer
    Journal of neurology 235 (1988), S. 407-410 
    Details
    ISSN: 1432-1459
    Keywords: Anticoagulant therapy ; Non-valvular atrial fibrillation ; Cerebral embolism ; Recurrent stroke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For the prevention of recurrent embolic stroke, 23 elderly patients with non-valvular atrial fibrillation (NVAF) were treated with oral anticoagulants (warfarin) during a mean period of 3.8 years. Only one patient suffered recurrent embolism, and another had acute myocardial infarction. There was no cerebral haemorrhage during the treatment. In an untreated control group (from an autopsy series), recurrent embolic strokes occurred in 18 of 70 NVAF patients (26%) during a mean period of 1.3 years. Long-term anticoagulant therapy appears to be effective in the prevention of recurrent embolic stroke in elderly patients with NVAF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314482
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Chronic levodopa therapy enhances dopa absorption: Contribution to wearing-off (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 1177-1185 
    Details
    ISSN: 1435-1463
    Keywords: Levodopa ; pharmacokinetics ; absorption ; wearing-off ; LNAA system ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of the chronic administration of levodopa on its peripheral pharmacokinetics and the contribution of the pharmacokinetics to the pathogenesis of the wearing-off phenomenon are re-evaluated. The concentration of plasma levodopa and clinical symptoms were determined 4 hours after oral levodopa (levodopa 100 mg+benserazide 25 mg) administration on 55 parkinsonian patients. Long-term levodopa therapy markedly increased the peak levodopa concentration (Cmax) and the area under the time-concentration curve (AUC); whereas, it decreased time to the peak concentration (Tmax) and the elimination half-life (T1/2). These results suggest that longterm levodopa therapy accelerates the absorption of levodopa. The wearingoff group (n=23), however, had a markedly higher Cmax and AUC, and a shorter Tmax and T1/2 than the stable group (n=32). We speculate that the clinical expression of “stable” or “wearing-off” depends on the absorption of levodopa as well as the presynaptic terminal and post synaptic receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271202
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Age-related decrease in responsiveness to L-DOPA is not due to changes in dopamine receptor mRNAs or G protein mRNAs (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 343-348 
    Details
    ISSN: 1435-1463
    Keywords: Age-related change ; dopamine receptor ; G protein ; mRNA ; L-DOPA responsiveness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the cause of the age-related decrease in the responsiveness to L-DOPA seen in parkinsonian patients, we studied age-related changes in the mRNA levels of dopamine receptors (D1, D2) and of G proteins (Gs, Gi, Go) in 22 control human brains aged 50–105 years. Neither the mRNA levels of dopamine receptors or of the G proteins changed with age. Another factor in the receptor-G protein casccade, such as guanine nucleotide binding, may cause the age-related decrease in responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271245
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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