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  • Cat  (2)
  • Albumin  (1)
  • Autoradiography  (1)
  • CDR1  (1)
  • Cortex  (1)
  • 1
    Digitale Medien
    Digitale Medien
    A ventral lateral geniculate nucleus projection to the dorsal thalamus and the midbrain in the cat (1978)
    Springer
    Experimental brain research 31 (1978), S. 95-106 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Ventral lateral geniculate ; Intralaminar nuclei ; Cat ; Horseradish peroxidase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Retrograde tracing experiments using horseradish peroxidase (HRP) have been utilized for demonstrating the origin of efferent projections of the ventral lateral geniculate nucleus (LGNv) in the cat. HRP-positive cells identifiable as origins of thalamic projections were found in LGNv after injections of HRP into the lateral central intralaminar nucleus. The labeled cells appeared concentrated in the medial part of the internal division of LGNv, consisting of medium-sized multipolar cells. Contralaterally, fewer labeled cells were present in the corresponding part of LGNv. In the case of injections of HRP into the midbrain (pretectum and superior colliculus), labeled cells in LGNv were distributed almost exclusively in its external division, composed of mainly small cells. Little overlap of the distribution of HRP-positive cells was seen in LGNv between the thalamic and midbrain injection cases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00235807
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  • 2
    Digitale Medien
    Digitale Medien
    Synergistic effect of ofloxacin and fluconazole against azole-resistant Candida albicans (2000)
    Springer
    Journal of infection and chemotherapy 6 (2000), S. 151-154 
    Details
    ISSN: 1437-7780
    Schlagwort(e): Key words Ofloxacin ; Fluconazole ; CDR1 ; Candida albicans ; Rhodamine 6G
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We investigated the combination effects of ofloxacin and fluconazole against azole-resistant Candida albicans strains in vitro and in vivo. Ofloxacin alone showed no efficacy against the azole-resistant C. albicans strain, C26. The in-vitro combination effects were evaluated by the checkerboard method, calculated as the fractional inhibitory concentration (FIC) index, but there was no synergistic effect of the combination. The activity of the drug efflux pump in the azole-resistant C. albicans strains was measured by intracellular rhodamine 6G concentration. When the cells were incubated with ofloxacin or grepafloxacin, the intracellular rhodamine 6G concentration was significantly increased in the azole-resistant C. albicans strain. In-vivo combination effects were evaluated in murine disseminated candidiasis. The survival of the mice was not prolonged, but counts of the yeast cells in the kidney and spleen were reduced following treatment with the combination of ofloxacin (20 mg/kg) and fluconazole (20 mg/kg). The combination of ofloxacin and fluconazole may represent an effective strategy to treat infections caused by azole-resistant C. albicans.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s101560070014
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  • 3
    Digitale Medien
    Digitale Medien
    Ascending projections from the nucleus of the brachium of the inferior colliculus in the cat (1984)
    Springer
    Experimental brain research 54 (1984), S. 203-211 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Ascending auditory pathway ; Inferior colliculus ; Medial geniculate body ; Cat ; Autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ascending projections from the nucleus of the brachium of the inferior colliculus (NBIC) in the cat were studied by the autoradiographic tracing method. Many fibers from the NBIC ascend ipsilaterally in the lateral tegmentum along the medial border of the brachium of the inferior colliculus. At midbrain levels, fibers from the NBIC end in the superior colliculus, the pretectum, the central gray and the peripeduncular tegmental region bilaterally with ipsilateral predominance. NBIC fibers to the superior colliculus are distributed densely to laminae VI an III throughout the whole rostrocaudal extent of the colliculus. In the pretectum, NBIC fibers terminate in the anterior and medial nuclei and the nucleus of the posterior commissure. NBIC fibers to the dorsal thalamus are distributed largely ipsilaterally. Many NBIC fibers end in the dorsal and medial divisions of the medial geniculate body, but few in the ventral division. The NBIC also sends fibers to the suprageniculate, limitans and lateralis posterior nuclei and the lateral portion of the posterior nuclear complex; these regions of termination of NBIC fibers constitute, as a whole, a single NBIC recipient sector. Additionally, the NBIC sends fibers to the centralis lateralis, medialis dorsalis, paraventricular and subparafascicular nuclei of the thalamus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00236219
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  • 4
    Digitale Medien
    Digitale Medien
    Opioid mechanisms involved in the slow potential change and neuronal refractoriness during cortical spreading depression (1987)
    Springer
    Experimental brain research 69 (1987), S. 113-118 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Slow potential change ; Spreading depression ; Cortex ; Naloxone ; Electroconvulsant shock ; Microiontophoresis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The slow potential change (spc) accompanying spreading depression (SD) was studied in rats and in a seizure-sensitive strain of Mongolian gerbil under three different experimental paradigms, each involving the use of naloxone. Gerbils undergoing electroconvulsive shock treatment displayed SD during the post-ictal phase, which was blocked by the intraperitoneal (i.p.) administration of naloxone (20–50 mg kg-1). Topical application of naloxone to the exposed cortex of the anaesthetized gerbil and rat blocked the spc of SD evoked by KCl. Microiontophoretic ejection of naloxone during extracellular recordings reversed cell refractoriness following the spc, demonstrated by the observation of a maintained sensitivity to iontophoretic pulses of glutamate. The results suggest a possible involvement of naloxone-sensitive processes in the mechanism responsible for cortical SD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00247034
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  • 5
    Digitale Medien
    Digitale Medien
    Human amniotic epithelial cells are promising transgene carriers for allogeneic cell transplantation into liver (2000)
    Springer
    Journal of human genetics 45 (2000), S. 171-176 
    Details
    ISSN: 1435-232X
    Schlagwort(e): Key words Human amniotic epithelial cells ; Cell transplantation ; Albumin ; Gene therapy ; Liver stem cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract As human amniotic epithelial tissue is formed on about the eighth day after fertilization, human amniotic epithelial cells (hAEC) may have multipotency to differentiate into various organs, such as brain, heart, or liver. In this study, we showed evidence of the synthesis and excretion of albumin by hAEC, by immunostaining and enzyme-linked immunoassay. Reverse transcription-polymerase chain reaction (RT-PCR) and western blot analyses revealed the expression of albumin mRNA and protein, respectively. In addition, hAEC also demonstrated immunoreactivity to genetic markers of liver lineage, such as human serum albumin and α-fetoprotein. Transplanted hAEC to Scid mouse liver showed positive immunoreactivity to albumin and α-fetoprotein. Genetically modified cells containing the β-galactosidase (LacZ) gene (AxCALacZ) were integrated in liver parenchyma. Human polymorphic gene analysis in Scid mouse liver after the implantation of hAEC showed that these Scid mouse livers obviously contained this human-specific gene until day 7 after the cell transplantation. As hAEC do not cause any acute rejection by allotransplantation, we conclude that hAEC may be useful as a transgene carrier to treat patients with inherited liver diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s100380050205
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