ISSN:
1432-1440
Keywords:
Digoxin
;
Sinus node function
;
Autonomic blockade
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of iv digoxin on normal sinus node function was studied after pharmacologic autonomic blockade (AB) in ten patients. Sinus cycle length (SCL), sinus node recovery time (SNRT) and sinoatrial conduction time (SACT) were determined before and after AB with propranolol (0.2 mg/kg body weight) and atropine sulfate (0.04 mg/kg body weight) iv, and 15 min, 30 min, and 45 min after 1 mg iv digoxin. AB resulted in a significant decrease (P〈0.01) in SCL (916±158 to 716±120 ms), in SNRT (1,229±221 to 871±190 ms), and in SACT (79±34 to 44±10 ms). Fifteen minutes after iv digoxin there was no significant change observed in SCL (716±120 to 708±92 ms), in SNRT (871±190 to 864±148 ms), or in SACT (44±10 to 46±15 ms). Similar results were obtained 30 min after digoxin administration. It is concluded that a single therapeutic dose of digoxin has no direct effect on electrophysiologic parameters of normal intrinsic sinus node function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01488720
Permalink
