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  • ESR  (2)
  • Industrial Chemistry and Chemical Engineering  (2)
  • hypertension  (2)
  • Alternative splicing  (1)
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Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Cloning of an isoform of mouse TGF-β type II receptor gene
    Amsterdam : Elsevier
    FEBS Letters 355 (1994), S. 19-22 
    Details
    ISSN: 0014-5793
    Keywords: Alternative splicing ; Serine-threonine kinase ; Transforming growth factor-β receptor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01156-7
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  • 2
    Electronic Resource
    Electronic Resource
    Vitamin B6 phototoxicity induced by UVA radiation (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 562-567 
    Details
    ISSN: 1432-069X
    Keywords: Keywords Vitamin B6 ; UVA ; Phototoxicity ; ESR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously reported that pyridoxine shows UVA-induced cytotoxicity. Four other vitamin B6 compounds (pyridoxal, pyridoxamine, pyridoxal phosphate, and pyridoxamine phosphate) are metabolically more important in vivo than pyridoxine. These compounds were examined for UVA phototoxicity to cultured human fibroblasts. The cytotoxicity was measured by post-UVA irradiation colony-forming ability. All the B6 compounds except pyridoxal phosphate showed cytotoxicity. Pyridoxamine phosphate, which is the most important form of vitamin B6 in vivo, had the strongest cytotoxic effect. To examine the involvement of reactive oxygen species in the phototoxicity, we performed an electron spin resonance study using the spin trapping agent, 5,5-dimethyl-1-pyrroline N-oxide, and diethylenetriaminepentaacetic acid. We failed to detect radicals derived from vitamin B6. The cytotoxic effect remained in UVA-irradiated solutions for at least 30 min after the end of UVA irradiation. Hydrogen peroxide was produced in the solution, but the amount was not enough to cause cytotoxicity. In addition, the cells from xeroderma pigmentosum patients who belong to group A or C showed survival curves similar to those of normal fibroblasts. This suggests that cyclobutane pyrimidine dimers or 6-4 photoproducts of DNA were not involved in this damage. These findings suggest that UVA-induced vitamin B6 cytotoxicity is caused by toxic photoproducts resulting from irradiated vitamin B6.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000174
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Reserpine, hydrochlorothiazide and pituitary-gonadal hormones in hypertensive patients (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 329-332 
    Details
    ISSN: 1432-1041
    Keywords: reserpine ; hydrochlorothiazide ; pituitary hormones ; gonadal hormones ; hypertension ; serum concentration ; antihypertensive therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Sex histories and serum samples were obtained from 27 hypertensive men before and after 3 months of therapy with either 100 mg of hydrochlorothiazide or 0.25 mg of reserpine daily. Sera were analyzed for testosterone, dihydrotestosterone, estradiol, luteinizing hormone and prolactin. Both drugs effectively lowered blood pressure. The incidence of impaired sexual performance was low and insignificantly different in the two treatment groups. There were no significant changes in serum hormone concentrations as a result of drug therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558444
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of prazosin and propranolol in combination with thiazide diuretics on blood pressure and serum lipids: a multicentre study (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 339-344 
    Details
    ISSN: 1432-1041
    Keywords: prazosin ; propranolol ; hypertension ; antihypertensive effects ; lipid metabolism ; multicentre study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have carried out randomized 12-week multicentre study to compare the effects of prazosin and propranolol on blood pressure and serum lipids in 70 patients with essential hypertension after a 4 week minimum period of treatment with thiazide diuretics. After 12 weeks treatment with prazosin (n=40, 1.5–12.0 mg per day) or propranolol (n=30, 30–120 mg per day) with diuretics there was a significant blood pressure reduction from 165.1/97.9 mmHg to 151.2/90.6 mmHg and from 167/96.5 mmHg to 153/91.9 mmHg, respectively. In the 12th week a significant decrease was noted in triglyceride and in low-density lipoprotein cholesterol (LDL + VLDL-C), but no significant effects were seen in high-density lipoprotein cholesterol (HDL-C) in patients receiving prazosin. On the other hand, a significant decrease in lecithin cholesterol acyltransferase (LCAT) was seen in patients receiving propranolol. Twenty-six of 40 patients receiving prazosin were given an additional 12 weeks of treatment. Twenty-two of 30 patients initially treated with propranolol were switched from propranolol to prazosin after 13 weeks and given prazosin up to the 24th week. At 24 weeks, the blood pressure was 149/93.0 mmHg in the prazosin group and 155/89.2 mmHg in the group which switched from propranolol to prazosin. Triglyceride remained reduced in the prazosin group at the 24th week. In the group which switched from propranolol to prazosin, triglyceride decreased significantly over the next 12 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637627
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  • 5
    Electronic Resource
    Electronic Resource
    ESR spectrometer with a wide frequency range using a gyrotron as a radiation power source (1995)
    Springer
    International journal of infrared and millimeter waves 16 (1995), S. 293-305 
    Details
    ISSN: 1572-9559
    Keywords: gyrotron ; ESR ; wide frequency range
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The development of a high frequency electron spin resonance (ESR) spectrometer with a wide frequency range using a gyrotron as the radiation power source is described. GYROTRON FU-E, optimized for use in an ESR spectrometer in the millimeter wave range, was developed in Fukui University. In order to test the normal operation of the spectrometer, the ESR of two standard samples, single crystal and polycrystalline DPPH, has been measured, in the pulsed mode over the frequency range from 65 GHz to 135 GHz.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02085864
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The epitaxial growth of AlGaAs using highly purified trimethylaluminum (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 5 (1991), S. 319-323 
    Details
    ISSN: 0268-2605
    Keywords: OMPVE ; epitaxy ; AlGaAs ; source gas ; trimethylaluminum ; impurity ; purification ; HEMT ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Highly purified trimethylaluminum [(CH3)3Al] was prepared by reducing the contamination of volatile impurities such as organic silicon and dimethyl-aluminum methoxide [(CH3)2AlOCH3]. The concentration of methoxy group in (CH3)3Al was found to decrease considerably when (CH3)2Al was distilled in the presence of aluminum trihalide. Among the halides, purification efficiency increased in the order I〉Br〉Cl.High-quality AlGaAs layer and AlGaAs/GaAs modulation doped structures were grown by organometallic vapor-phase epiloxy (OMVPE) using the purified (CH3)3Al. Their electrical properties were discussed in relation to the volatile impurity in the source gas.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aoc.590050416
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  • 7
    Electronic Resource
    Electronic Resource
    The epitaxial growth of gaas using alkylarsine: Part 2. molecular orbital calculation (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 5 (1991), S. 331-336 
    Details
    ISSN: 0268-2605
    Keywords: Molecular orbital ; calculation ; MOCVD ; source gas ; alkylarsine ; β-elimination ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Semi-empirical molecular orbital calculations were carried out for the compounds (C2H5)3As, (C2H5)3Ga and RAsH2 (R = C2H5, i-C3H7, i-C4H9, and t-C4H9) by using the CNDO/2-U program, and their capability of β-elimination reaction is compared on the basis of the torsion energy to the transition state, electrostatic interactions and orbital overlapping between the central atom and the β-hydrogen, and bond order of the metal-carbon, and carbon-hydrogen bond. In the comparison of (C2H5)3As with (C2H5)3Ga, we found that the β-elimination of (C2H5)3As could hardly be expected to take place in the thermal decomposition. The capability of β-elimination would be smaller in C2H5AsH2 than that in (C2H5)3As. Moreover when the ethyl group is replaced by a t-butyl group in RAsH2, the β-elimination reaction appears to become more difficult and a large possibility for a radical process is suggested.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aoc.590050418
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