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  • 1
    Electronic Resource
    Electronic Resource
    Familial predisposition to renal disease in two generations of Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus (1990)
    Springer
    Diabetologia 33 (1990), S. 438-443 
    Details
    ISSN: 1432-0428
    Keywords: Type 2 (non-insulin-dependent) diabetes mellitus ; American Indians ; diabetic renal disease ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the occurrence of renal disease by measuring serum creatinine and urine protein concentrations in the diabetic members of 316 Pima Indian families with Type 2 (non-insulin-dependent) diabetes in two successive generations to determine if diabetic renal disease aggregates in families. After adjustment for sex and other risk factors, proteinuria occurred among 14.3% of the diabetic offspring if neither parent had proteinuria, 22.9% if at least one diabetic parent had proteinuria, and 45.9% if both parents had diabetes and proteinuria. Among male offspring, an elevated serum creatinine concentration (≥177 μmol/l) was present in 11.7% if the parent had an elevated creatinine and in 1.5% if the parent did not. Thus, proteinuria and high serum creatinine aggregated in diabetic families, suggesting that susceptibility to renal disease is inherited independently of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404096
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  • 2
    Electronic Resource
    Electronic Resource
    Albuminuria in Type 2 (non-insulin-dependent) diabetes mellitus and impaired glucose tolerance in Pima Indians (1989)
    Springer
    Diabetologia 32 (1989), S. 870-876 
    Details
    ISSN: 1432-0428
    Keywords: Albuminuria ; prevalence ; diabetic nephropathy ; Type 2 (non-insulin-dependent) diabetes mellitus ; impaired glucose tolerance ; American Indians
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The prevalence of abnormal urinary albumin excretion, defined by a urine albumin to creatinine ratio〉-30 mg/g (approximately equivalent to an albumin excretion rate of 〉-30 mg/24 h), was determined in 2728 Pima Indians aged 〉-15 years from the Gila River Indian Community in Arizona, a population with a high prevalence of Type 2 (non-insulin-dependent) diabetes mellitus. Excessive albumin excretion was present in 8% of subjects with normal glucose tolerance, 15% of those with impaired glucose tolerance, and 47% of subjects with diabetes. The intermediate prevalence of abnormal albuminuria in those with impaired glucose tolerance suggests that hyperglycaemia even at levels below those diagnostic of diabetes is associated with renal abnormalities in some subjects and that these abnormalities may precede the onset of diabetes. Abnormal albuminuria at levels not reliably detected by the usual dipstick methods was commonly observed in Pima Indians with diabetes, even those with diabetes of recent onset. Associations were found with age, duration of diabetes, level of glycaemia, blood pressure, and treatment with insulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297452
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  • 3
    Electronic Resource
    Electronic Resource
    Parental hypertension and proteinuria in Pima Indians with NIDDM (1996)
    Springer
    Diabetologia 39 (1996), S. 433-438 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetic nephropathy ; hypertension ; familial predisposition ; non-insulin-dependent diabetes mellitus ; Pima Indians.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine if parental hypertension is associated with proteinuria in offspring with non-insulin-dependent diabetes mellitus (NIDDM), 438 diabetic Pima Indians (172 men, 266 women) aged 20 years or more and both of their parents were examined. Hypertension was defined as a systolic blood pressure 140 mm Hg or more, diastolic blood pressure 90 mm Hg or more, or treatment with antihypertensive medicine. Sixty-three percent of the fathers and 80 % of the mothers had diabetes at the time their blood pressure was measured. Families in which either parent had proteinuria, defined as a urine protein-to-creatinine ratio ≥ 0.5 g/g were excluded; 73 (16.7 %) of the offspring had proteinuria. The prevalence rates of proteinuria in the offspring were similar if neither parent or only one parent had hypertension (8.9 and 9.4 %, respectively), but was significantly higher if both parents had hypertension (18.8 %), after adjustment for age, sex, duration of diabetes, and 2-h post-load plasma glucose concentration in the offspring and diabetes in the parents by logistic regression. The odds for proteinuria being present in the offspring if both parents had hypertension was 2.2 times (95 % confidence interval, 1.2 to 4.2) that if only one parent had hypertension. When mean arterial pressure and blood pressure treatment in the offspring were added to the model the relationship remained (odds ratio = 2.2; 95 % confidence interval, 1.1 to 4.3). Hypertension in both parents is associated with the development of proteinuria in offspring with NIDDM. This relationship was present even when controlled for the effects of blood pressure and its treatment in the offspring. [Diabetologia (1996) 39: 433–438]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400674
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  • 4
    Electronic Resource
    Electronic Resource
    Changing glomerular filtration with progression from impaired glucose tolerance to Type II diabetes mellitus (Short Communications) (1999)
    Springer
    Diabetologia 42 (1999), S. 90-93 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetic Renal Disease Study ; glomerular filtration rate ; impaired glucose tolerance ; Type II diabetes ; Pima Indians.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glomerular filtration rate (iothalamate clearance) was measured serially for 48 months in 26 Pima Indians with impaired glucose tolerance and 27 with normal glucose tolerance. At baseline, the mean glomerular filtration rate (SEM) was 133 ± 8 ml/min in subjects with impaired glucose tolerance and 123 ± 5 ml/min in those with normal glucose tolerance (p = 0.12). In the 12 subjects with impaired glucose tolerance who progressed to Type II (non-insulin-dependent) diabetes during follow-up, mean glomerular filtration rate increased by 30 % (p = 0.011). Among the remaining 14 subjects with impaired glucose tolerance, 12 reverted to normoglycaemia. The glomerular filtration rate both at baseline and after 48 months in this subgroup exceeded the values of subjects with normal glucose tolerance by 20 % (p = 0.008) and 14 % (p = 0.013), respectively. A pronounced rise in the glomerular filtration rate occurs at the onset of Type II diabetes but a trend to hyperfiltration is also present in those with impaired glucose tolerance. [Diabetologia (1999) 42: 90–93]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051118
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  • 5
    Electronic Resource
    Electronic Resource
    Errata (1957)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 3 (1957), S. 7S 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690030326
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  • 6
    Electronic Resource
    Electronic Resource
    Dynamic behavior of a single screw plasticating extruder part I: Experimental study (1986)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 26 (1986), S. 144-151 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The dynamic responses of a 2-1/2 inch single screw plasticating extruder and extrusion line were investigated. Step changes in screw speed, take-up speed, back pressure, and processing materials were used to determine the transient responses of barrel pressures, die pressure, melt temperature, and extrudate thickness. Dynamic responses of the entire extrusion line can be explained by the flow mechanism of the extruder and the logical properties of the polymer used. A capillary rheometer was also used to determine if it could simulate pressure responses in the extruder for screw speed changes. Results showed that capillary rheometer was helpful in estimating the short term pressure responses in the die.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760260206
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  • 7
    Electronic Resource
    Electronic Resource
    Dynamic behavior of a single screw plasticating extruder part II: Dynamic modeling (1986)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 26 (1986), S. 152-161 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The dynamic response of a 2.5 inch plasticating extruder and the extrusion line are modeled using high density polyethylene and acrylics us extrudate. Screw speed, back pressure valve position, and material changes are used as forcing functions. Three fundamental transfer functions in the Laplace domain: a first order, a second order, and a lead-lag, are developed to simulate the short term and long term responses of temperatures, pressures, and extrudate thickness. A kinetic-elastic model which can predict rheological properties of non-Newtonian, viscoelastic materials is also applied to the pressure responses of the extrusion process. This model can fit the experimental data well but due to the complexity involved in its parameter setting, more modifications are required before it can be applied for the control of extrusion process.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760260207
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  • 8
    Electronic Resource
    Electronic Resource
    Identification of FAMEs using ECL values and a three-dimensional Kováts retention index system (1995)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 18 (1995), S. 167-170 
    Details
    ISSN: 0935-6304
    Keywords: High resolution GC (HRGC) ; Fatty acid methyl esters (FAMEs) ; Equivalent chain length (ECL) values ; Kováts retention index ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: n-Alkanes and fatty acid methyl esters have been chromatographed on four capillary columns of different polarity (LM-1 (100% polydimethylsiloxane), CB-225 (25% cyanopropyl, 25% phenyl polysiloxane), LM-100 (immobilized polyethylene glycol), and BPX-70 (70% cyanopropyl polysiloxane)) with the goal of identifying the major fatty acid methyl esters obtained by derivatization of vegetable oils. Chromatographic retention data were employed for the construction of a three-dimensional Kováts retention index system and for the elaboration of a table of equivalent chain length values.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240180306
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  • 9
    Electronic Resource
    Electronic Resource
    Conformational analysis of 7,7-dichloro-2,5-dioxabicyclo[4.1.0] heptane by NMR (1974)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 6 (1974), S. 303-304 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 1H NMR spectra of 7,7-dichloro-2,5-dioxabicyclo-[4.1.0]heptane (1) were analyzed through the application of programs NMRIT and NMREN2.See Ref. 1. The half-chair conformation of 1 was obtained from the vicinal coupling constants by the Buys R method.See Ref. 2.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270060602
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