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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 52 (1983), S. 423-428 
    ISSN: 1432-1106
    Keywords: Human posture ; Postural “reflexes” ; Change of latency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The functional role of spinal and supraspinal EMG-responses for the maintenance of upright human posture was investigated in ten healthy subjects standing on a force measuring platform, which could be rotated in pitch around an axis aligned with the subject's ankle joint. Voluntary changes of body posture prior to the platform movement by leaning forward or backward led to a change in the amplitude and temporal organization of EMG-responses as compared to platform movements starting from a neutral position. Tilting the platform toe-up while leaning backward led to an increase of the latency of the short- and medium-latency responses in the triceps surae muscle and to a decrease of the latency of the stabilizing response in the anterior tibial muscle. Functionally, a cocontraction of both antagonistic muscles could be observed which partly compensated for the destabilizing action of the “reflex” response in the stretched triceps surae muscle. In analogy, leaning forward and tilting the platform toedown led to a cocontraction of the two antagonistic muscles. The observed changes of latencies of short-, medium-, and long-latency response show the functional variability of segmental and suprasegmental “reflex” mechanisms. EMG-activities, which are functionally destabilizing posture, can be suppressed or compensated by reflexive cocontractions of antagonists.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 246 (1999), S. 515-519 
    ISSN: 1432-1459
    Keywords: Key words Migraine attack ; 5-HT1B/1D agonists ; Analgesics ; Ergotamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Migraine is a paroxysmal disorder characterized by attacks of headache, nausea, vomiting, photophobia, phonophobia, and malaise. This review summarizes new treatment options for therapy of the acute attack. Mild or moderate migraine attacks are treated with antiemetics followed by analgesics such as aspirin, paracetamol, nonsteroidal anti-inflammatory drugs, or antiemetics combined with ergotamine or dihydroergotamine. Sumatriptan, a specific serotonin (5-HT)1B/D agonist is used when attacks do not respond to ergotamine, or when intolerable side effects occur. The new migraine drugs zolmitriptan, naratriptan, rizatriptan, and eletriptan differ slightly in their pharmacological profiles, which translates into minor differences in efficacy, headache recurrence, and side effects. New drugs in migraine prophylaxis include cyclandelate, valproic acid and magnesium.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1459
    Keywords: Chronic headache ; Analgesics ; Withdrawal therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Headache characteristics are described in 139 patients with chronic daily or almost daily headaches due to regular intake of analgesics and the short- and long-term results of drug withdrawal. Drug-induced headache was described as dull, diffuse, and band-like, and usually started in the early morning. The mean duration of the original headache (migraine or tension headache) was 25 years; regular intake of drugs and chronic daily headache had started 10 and 6 years prior to withdrawal therapy, respectively. Patients took an average of 34.6 tablets or analgesic suppositories or antimigraine drugs per week containing 5.8 different substances. The drugs most often used were caffeine (95%), ergotalkaloids (89%), barbiturates (64%), and spasmolytics, paracetamol, and pyrazolone derivates (45%–46%). A total of 103 patients (68 migraine, 35 tension or combination headache) were available for interviews at a mean time interval of 2.9 years after an inpatient drug withdrawal programme. Chronic headache had disappeared or was reduced by more than 50% in two-thirds of the patients. Positive predictors for successful treatment were migraine as primary headache, chronic headache lasting less than 10 years, and regular intake of ergotamine. Drug intake was significantly reduced and patients used single substances more often. Patients who originally suffered from migraine, superimposed on the daily headache, also experienced a significant improvement in the frequency of the migraines and their intensity. Migraine prophylaxis through beta-blocking agents and calcium channel antagonists was more efficient after drug-withdrawal therapy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 45 (1982), S. 126-132 
    ISSN: 1432-1106
    Keywords: Human posture ; Induced sway ; Visual stabilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Displacements of the center of foot pressure, the hip and the head were recorded in six subjects standing on a platform, sinusoidally tilting in pitch(anterior-posterior).Stimulusfrequenciesranged between 0.01 and 1 Hz. Stimulus amplitudes were 2, 4 and 6 °. With eyes open the displacements were minimal at 0.3 Hz. With eyes closed, however, induced sway was maximal at this frequency. The apparent lack of visual stabilization at the lowest frequency (0.01 Hz) might be attributed to a subthreshold velocity of the retinal image motion induced by the swaying body. A similar absence of visual stabilization at 1 Hz is assumed to indicate the limit of the working range of visual stabilization of posture. Independent of stimulus amplitude a phase lead of about 90 ° was found at 0.01 Hz. This decreased with increasing frequency up to a phase lag of 100 ° at the highest frequency (1 Hz). Head stabilization was generally more effective than hip stabilization. EMG recordings from the leg muscles suggest that with eyes closed the center of force is mainly stabilized by leg muscle activity, while with eyes open this stabilization is best, when vision allows for stabilization of body posture by intersegmental movements between head, trunk and legs.
    Type of Medium: Electronic Resource
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