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  • 1
    Electronic Resource
    Electronic Resource
    Antimigraine drugs (1999)
    Springer
    Journal of neurology 246 (1999), S. 515-519 
    Details
    ISSN: 1432-1459
    Keywords: Key words Migraine attack ; 5-HT1B/1D agonists ; Analgesics ; Ergotamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Migraine is a paroxysmal disorder characterized by attacks of headache, nausea, vomiting, photophobia, phonophobia, and malaise. This review summarizes new treatment options for therapy of the acute attack. Mild or moderate migraine attacks are treated with antiemetics followed by analgesics such as aspirin, paracetamol, nonsteroidal anti-inflammatory drugs, or antiemetics combined with ergotamine or dihydroergotamine. Sumatriptan, a specific serotonin (5-HT)1B/D agonist is used when attacks do not respond to ergotamine, or when intolerable side effects occur. The new migraine drugs zolmitriptan, naratriptan, rizatriptan, and eletriptan differ slightly in their pharmacological profiles, which translates into minor differences in efficacy, headache recurrence, and side effects. New drugs in migraine prophylaxis include cyclandelate, valproic acid and magnesium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050396
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analgesic-induced chronic headache: long-term results of withdrawal therapy (1989)
    Springer
    Journal of neurology 236 (1989), S. 9-14 
    Details
    ISSN: 1432-1459
    Keywords: Chronic headache ; Analgesics ; Withdrawal therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Headache characteristics are described in 139 patients with chronic daily or almost daily headaches due to regular intake of analgesics and the short- and long-term results of drug withdrawal. Drug-induced headache was described as dull, diffuse, and band-like, and usually started in the early morning. The mean duration of the original headache (migraine or tension headache) was 25 years; regular intake of drugs and chronic daily headache had started 10 and 6 years prior to withdrawal therapy, respectively. Patients took an average of 34.6 tablets or analgesic suppositories or antimigraine drugs per week containing 5.8 different substances. The drugs most often used were caffeine (95%), ergotalkaloids (89%), barbiturates (64%), and spasmolytics, paracetamol, and pyrazolone derivates (45%–46%). A total of 103 patients (68 migraine, 35 tension or combination headache) were available for interviews at a mean time interval of 2.9 years after an inpatient drug withdrawal programme. Chronic headache had disappeared or was reduced by more than 50% in two-thirds of the patients. Positive predictors for successful treatment were migraine as primary headache, chronic headache lasting less than 10 years, and regular intake of ergotamine. Drug intake was significantly reduced and patients used single substances more often. Patients who originally suffered from migraine, superimposed on the daily headache, also experienced a significant improvement in the frequency of the migraines and their intensity. Migraine prophylaxis through beta-blocking agents and calcium channel antagonists was more efficient after drug-withdrawal therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314210
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Neuropsychological changes associated with stenoses or occlusions of the carotid arteries (1984)
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 69-73 
    Details
    ISSN: 1433-8491
    Keywords: Extracranial vascular disease ; Neuropsychological deficit ; Carotisstenose ; Neuropsychologische Veränderungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Studie wurden 33 Patienten mit hämodynamisch relevanten Carotisstenosen oder -verschlüssen psychodiagnostisch untersucht. 22 litten an transitorisch ischdmischen Attacken, 6 hatten einen leichten Schlaganfall erlitten, 5 waren asymptomatisch. Patienten mit hämodynamisch relevanten Carotisstenosen Im Vergleich mit der altersentsprechenden Normalpopulation waren die intellektuellen Funktionen intakt; es bestanden aber deutliche Einschränkungen im mnestischen Bereich, in der Aufmerksamkeit und im Bereich psychomotorischer Reaktionen. Für die Ausprägung der neuropsychologischen Ausfälle war es irrelevant, ob uni- oder bilatere Stenosen im Carotiskreislauf vorlagen. Die Untersuchung zeigt, daß auch bei asymptomatischen Patienten und solchen mit reversiblen neurologischen Ausfdllen bereits manifeste neuropsychische Störungen bestehen können.
    Notes: Summary A total of 33 patients with a relevant stenosis or occlusion of extracranial arteries were tested for a number of neuropsychological functions. Most of them [22] suffered from transient ischemic attacks, 6 from strokes, 5 were asymptomatic. Compared to an age-matched population of normals, patients showed an impairment in their mnemic functions, and attention under stress as well as in their psychomotor function. The degree of neuropsychological impairment was independent of the unilaterality or bilaterality of carotid stenoses. The results illustrate the neuropsychological deficit even in asymptomatic patients and those with complete recovery from transient neurological deficits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432886
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Neuropsychological functions after carotid endarterectomy (1984)
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 74-77 
    Details
    ISSN: 1433-8491
    Keywords: Carotid endarterectomy ; Neuropsychological changes ; Endarterektomie ; Carotisstenose ; Neuropsychologische Veränderungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir führten bei 23 Patienten mit uni- oder bilateralen hämodynamisch relevanten Carotisstenosen vor und zehn Monate nach einer Endarterektomie testpsychologische Untersuchungen durch. Präoperativ hatten die meisten Patienten TIA (15), fünf hatten einen leichten Schlaganfall erlitten, drei waren asymptomatisch. Die Nachuntersuchung zeigte leicht verbesserte intellektuelle Funktionen, während die mnestischen Funktionen eher schlechter waren als vor der Operation. Die psychomotorischen Funktionen zeigten — ebenso wie die persönlichkeitsbezogenen Tests — keine wesentlichen Unterschiede. Die prophylaktische Wirkung der Endarterektomie zur Vorbeugung von Schlaganfällen ist unumstritten; eine wesentliche Verbesserung der neuropsychologischen Veränderung ist aber in der Regel nicht zu erwarten
    Notes: Summary Psychological testing was performed on 23 patients (mean age 60.7 years) with unilateral or bilateral stenoses of the carotid arteries prior to and 10 months after carotid endarterectomy. Intellectual functions were slightly improved, mnemic functions impaired, psychomotor functions and dimension of personality remained unchanged. Carotid endarterectomy, although improving neuropsychological functions in a few cases, on average does not cause a significant improvement. This underscores the preventive character of the surgical intervention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432887
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    Paper (German National Licenses)
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