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  • Analytical Chemistry and Spectroscopy  (1)
  • Anxiety  (1)
  • Atenolol  (1)
  • Cell culture  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Medazepam and the driving ability of anxious patients (1977)
    Springer
    Psychopharmacology 52 (1977), S. 103-106 
    Details
    ISSN: 1432-2072
    Keywords: Medazepam ; Driving ability ; Anxiety ; Depression ; Middlesex health questionnaire
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A double blind crossover trial of Medazepam was carried out in 14 anxious hospital patients. The mean self-adjusted dosage was 16.5 mg daily. The active drug was no more effective than placebo in relieving anxiety, which was rated both clinically and by the Middlesex Health Questionnaire (M.H.Q.) (Crown and Crips, 1970). This may have been because the dose was relatively low for chronically anxious hospital patients. Even this dosage caused significantly higher scores on the M.H.Q. scale for depression. Braking and driving simulator tests were not adversely affected by Medazepam. In real driving conditions those taking the drug made significantly more technical, but not dangerous, errors. Pulse and blood pressure also were not affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426608
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evolution of atenolol kinetics when hypothyroidism is corrected (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 185-188 
    Details
    ISSN: 1432-1041
    Keywords: Atenolol ; Hypothyroidism ; Drug absorption ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A single oral dose of atenolol 100 mg was given to 7 hypothyroid patients (4 F, 3 M), before and after correction of hypothyroidism, mean delay 3.5 months (2 to 6.5 months). There was no change in the elimination parameters of atenolol, but the maximal plasma atenolol concentration was increased (1.66 to 7.37 mg·l−1) as was the AUC (14.9 to 52.1 mg·l−1·h) when the hypothyroidism had been treated. Only one patient differed: he had had a supra-selective vagotomy, and had similar curves before and after treatment of the hypothyroidism, both being similar to the plasma concentration curves found in the other patients after correction of the hypothyroidism. The results suggest an increase in the bioavailability of atenolol when hypothyroidism is corrected. The findings in the patient with vagotomy suggest that the decreased bioavailability during hypothyroidism might be related to changes in intestinal pH. Further studies are needed of the impact of hypothyroidism on gastric and pancreatic or biliary function and its consequences for drug absorption, and drug pharmacokinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265982
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Presence of adrenal medullary chromaffin cells in primary adrenal dispersions and their persistence in long-term culture (1982)
    Springer
    Cell & tissue research 227 (1982), S. 225-229 
    Details
    ISSN: 1432-0878
    Keywords: Chromaffin cells ; Adrenocortical cell suspensions ; Cell culture ; Catecholamine fluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cell suspensions prepared by enzymatic dispersion of whole rat adrenal glands for the purpose of studying adrenocortical cells were found to contain chromaffin cells even though they are commonly thought to not survive in such preparations. These cells fluoresced when treated with methods specific for catecholamines. The fluorescent cells persisted in the cultures of “cortical” cells, took on the morphology of neurons in the cultures, maintained their specific catecholamine fluorescence in long-term cultures, and ultrastructurally were identical to chromaffin cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206344
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Elemental X-ray mapping of cementitious phases using an energy-dispersive spectrometer in the scanning electron microscope (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 7 (1978), S. 145-147 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Elemental X-Ray mappings on Portland cement clinkers have been obtained using a scaning electron microscope-energy dispersive system (SEM-EDS). Using this method, elemental mapping of the major constituents of cement (Ca, Si, Al, Fe) can be generated in as little as 300 s, while the minor constituents(〈10%) Such as Na, Mg, P, S, K yield poorer contrast mappings. The technique used and the resultant mappings obtained are discussed.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300070306
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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