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  • Analytical Chemistry and Spectroscopy  (2)
  • Autophagic vacuole  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Tubulomembranous and fingerprint-like inclusions in biopsied muscle of distal myopathy with rimmed vascuoles (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 194-200 
    Details
    ISSN: 1432-0533
    Keywords: Tubulomembranous structure ; Fingerprint-like structure ; Distal myopathy ; Rimmed vacuole ; Autophagic vacuole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Muscle biopsies from four patients were studied histochemically and electron-microscopically: they had myopathy of juvenile or early-adult onset, in which distal limb muscles were most severely affected but muscles supplied by cranial nerves were spared. Common histochemical findings included variation in fiber size, necrosis, phagocytosis, fiber splitting, central nuclei, endomysial fibrosis, and particularly rimmed vacuoles. Electron-microscopic examination revealed frequent autophagic vacuoles with numerous myeloid bodies. In addition, sarcoplasmic inclusion bodies with periodically laminated structures similar to the tubulomembranous structures (TMSs) first described by Fukuhara et al. (1981) in an atypical myopathy were found in all four cases, and in one, there were fingerprint-like structures resembling those described in neuronal ceroid-lipofuscinoses. These inclusions occasionally contained areas resembling lipofuscin pigment. They are certainly residual bodies of lysosomal origin, which might be related to the rimmed-vacuolar degeneration of the muscle, but whether or not they represent some specific metabolic abnormalities seems to remain an open question since the present cases differed clinically from either of the atypical myopathies with TMSs (Fukuhara et al. 1981) or any type of neuronal ceroid-lipofuscinosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691852
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rimmed vacuolar distal myopathy (1987)
    Springer
    Journal of neurology 234 (1987), S. 137-145 
    Details
    ISSN: 1432-1459
    Keywords: Rimmed vacuolar distal myopathy ; Autophagic vacuole ; Golgi's apparatus ; Lysosome ; Tubulomembranous structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ultrastructural study of biopsied muscles was performed in seven patients with rimmed vacuolar distal myopathy, which was characterized by prominent rimmed vacuoles in the muscle fibers. The earliest changes noted were focal proliferation of the Golgi's apparatus and mitochondrial degeneration with myofibrillar loss. A proliferation of the T-system appeared later. Secondary lysosomes (autophagosomes) could be noted much later and gradually increased in number. Autophagosomes tended to coalesce and became larger autophagic vacuoles, which were surrounded in part by relatively preserved myofibrils and partly by a single membrane. Gently curved laminated structures (tubulomembranous structures) were seen in the degenerating muscle fibers and also in relatively intact fibers, satellite cells, and interstitial cells in all cases. They were closely associated with lipofuscin-like material. These findings suggest that an abnormality of the lysosomal system might be essential in the pathogenesis of rimmed vacuolar distal myopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314132
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Studies of open tubular micro capillary liquid chromatography. 1. The development of open tubular micro capillary liquid chromatography (1978)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 1 (1978), S. 21-27 
    Details
    ISSN: 0935-6304
    Keywords: Liquid Chromatography ; Capillary, glass ; Preparation of LC-Capillaries ; Investigation of column parameters ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Micro capillary columns were successfully applied to liquid chromatography by employing the principles used in micro high performance liquid chromatography. Fundamental investigations on the use of capillary columns in LC were performed for the various column parameters. Good separations of five aromatic hydrocarbons and four kinds of phthalic esters were obtained on a 62 μm I.D. capillary column, coated with SE-30.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240010106
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  • 4
    Electronic Resource
    Electronic Resource
    Study of open-tubular micro-capillary liquid chromatography (1979)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 2 (1979), S. 371-377 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography, HPLC ; Capillary, glass ; Review on open tubular micro capillary LC ; Technical solutions of the problems in zero dead volume connections ; Capillary LC/MS combination ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Capillary columns in gas chromatography, first proposed by Golay [1,2], have become well established [3] which have extremely high column efficiencies and separabilities. Everyone could imagine it to be a great tool if such a kind of high efficiency column could be established in liquid chromatography (LC). Microcapillary liquid chromatography (MCLC) may be one way of achieving high-efficiency in terms of theoretical plates. Few papers were published in this field before 1976 [4-6], but more recently, after 1977 [7-15], this field has become one of topical interest in liquid chromatography. Temporarily there are two microcapillary liquid chromatography, that is: „open-tubular“ [7,8,10-15] and „packed“ [9] MCLC. In this presentation we focus on open-tubular microcapillary liquid chromatography and a review contemporary developments of ours and others.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240020621
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