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  • 1
    Electronic Resource
    Electronic Resource
    The effect of estradiol on the sebaceous gland of the hamster ear and its antagonism by tamoxifen (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 230-234 
    Details
    ISSN: 1432-069X
    Keywords: Sebaceous gland ; Estradiol ; Tamoxifen ; Histoplanimetry ; Androgen effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the antagonism between estradiol and tamoxifen in the sebaceous gland of the hamster ear, animals were topically treated, and the size of the sebaceous glands was measured by histoplanimetry. The systemic effects were described by determining the estradiol and testosterone plasma levels and within the testes, and the size of the seminal vesicles and the contralateral sebaceous gland. The administration of 0.1 μg estradiol resulted in a diminution in the size of the treated glands but left all other parameters unchanged, indicating a purely local effect. A higher dose of estradiol (1 μg) further decreased the size of the treated glands, but this was combined with a systemic effect, i.e. low plasma testosterone, decrease in testis size and a diminution of the contralateral ear gland. Ten micrograms of estradiol maximally suppressed all of the androgen effects without side effects. The administration of tamoxifen alone also decreased the size of the sebaceous glands without side effects, but it did not affect the production or effects of androgens. When administered in combination with estradiol, it antagonized the effects of this hormone completely. We conclude that tamoxifen inhibits the negative effect of estradiol on sebaceous-gland size. It acts predominantly in a systemic manner, because a metabolisation to monohydroxytamoxifen is necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404322
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    355. Zur Wirksamkeit von Fibrinogen und Thrombin bei der Deckung experimenteller Verbrennungswunden (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 907-907 
    Details
    ISSN: 1435-2451
    Keywords: Burn injuries ; Mesh graft ; Fibrin glue ; Verbrennung ; Mesh-Graft ; Fibrinkleber
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Experimentelle Verbrennungswunden an der Rückenhaut von Ratten (n = 20) im Bereich des thoracolumbalen Übergangs wurden mit Haut-Mesh-graft gedeckt, wobei in der Versuchsgruppe zusätzlich Fibrinkleber (Tissuecol) verwendet wurde. Planimetrische Auswertungen der nach 14 Tagen verbleibenden Wundflächen sowie mikroangiographische, histologische und thermographische Untersuchungen zeigen ein verbessertes Einheilen des Transplantates bei gleichzeitiger Fibrinkleberapplikation, was durch den festen initialen Kontakt zum Wundgrund und die verbesserte Blutstillung erklärt werden kann.
    Notes: Summary Experimental bum injuries in the dorsal thoracolumbar region of rats were covered by skin mesh grafts. In the treated group, fibrin adhesive (Tissucol) was also applied. Fourteen days after transplantation planimetric localization of the remaining wound area, microangiographic, histologic and thermographic studies demonstrated a better healing of the transplant additionally treated with fibrin adhesive. This can be explained by the fibrin-initiated contact with the wound and the hemostyptic effect of the fibrin adhesive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276181
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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