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  • 1
    Electronic Resource
    Electronic Resource
    Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 418-423 
    Details
    ISSN: 1432-0533
    Keywords: Fibroblast growth factor (FGF) ; Basic FGF ; Angiogenesis ; Brain tumors ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibroblast growth factor (FGF) is a potent angiogenic factor and a mitogen for a variety of mesoderm-and neuroectoderm-derived cell types (e.g., fibroblasts, endothelial cells, astrocytes, oligodendrocytes). After application of a monospecific polyclonal antiserum, we localized basic FGF on frozen sections of 73 human brain tumors using immunohisto-chemistry. FGF was present in a variable number of tumor cells (16/16 astrocytomas, 5/5 ependymomas, 0/3 benign and 4/7 anaplastic oligodendrogliomas, 11/12 glioblastomas, 11/11 meningiomas, 6/6 neurilemmomas, 0/3 pituitary adenomas, 2/2 choroid plexus papillomas, 0/1 neurocytoma, 2/2 benign fibrous histiocytomas, 2/5 metastatic carcinomas). FGF was detected in vascular cells of 59 tumors and in fibroblasts of connective tissue stroma from all papillomas and metastases. These results tend to indicate FGF involvement in the malignant progression of gliomas due to an autocrine or paracrine action. Histopathological aspects of malignant gliomas (e.g., pseudopalisading or pathological vessels) could be related to FGF activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308718
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cultivation and growth of dissociated neurons from chick embryo cerebral cortex in the presence of different substrates (1971)
    Springer
    Cell & tissue research 117 (1971), S. 559-569 
    Details
    ISSN: 1432-0878
    Keywords: Cerebral cortex ; Dissociated cells ; Chick embryo ; Cultivation in vitro ; Influence of substrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dissociated cells from 7-day old chick embryo cerebral hemispheres were cultivated for one month in Rose chambers. Four different culture conditions were employed in the composition of the matrix on which the cells were cultivated: collagen alone, collagen plus embryonic extract, collagen plus plasma and collagen plus plasma and embryonic extract. Within the first 48 hours of cultivation the cells formed processes under all four culture conditions. In the presence of plasma the dissociated cells remained well isolated; in the other culture conditions many cells reassociated into clumps. After 2–3 weeks in cultures on collagen or collagen plus embryonic extract many polygonal cells developed and formed a layer upon which typical neurons and oligodendrocyte-like cells were observed. After 3 weeks the polygonal cells began to transform into astrocyte-like cells. In the presence of plasma the cell bodies of the neuroblasts remained small and round. The processes developed generally consisted of one long and many short thick fibres; all processes had a bulbous appearance. In 3–4-weeks old cultures the cells which remained viable, were morphologically unchanged. The differences in the morphological aspects of the cells cultivated on plasma and those cultivated on collagen alone or with embryonic extract are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330715
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    Paper (German National Licenses)
    Fulltext
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