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  • Anterior  (1)
  • Anterior cruciate ligament  (1)
  • Antioxidants  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Heart muscle ubiquinone and plasma antioxidants following cardiac transplantation (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. S76 
    Details
    ISSN: 1432-1440
    Keywords: Heart transplantation ; Heart ubiquinone ; Blood and plasma ubiquinone ; Plasma α-tocopherol ; Transplant rejection ; Free radicals ; Antioxidants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nine patients who underwent heart transplantation (one female; average age 48 ± 11, range 19–58 years) were followed in respect to contents of right-sided heart septum, blood and plasma ubiquinone (UQ), plasma α-tocopherol (αT), and plasma free cholesterol (FC). In contrast to healthy persons, substantial inter- and intraindividual variations were observed; individually low values were seen with rejection. Heart muscle UQ in well-treated patients averaged 0.33 ± 0.08, range 0.06–0.58 μg mg−1 (0.38 ± 0.09 μmol g−1 dry weight) and was not different from healthy individuals. Plasma UQ, αT; and FC averaged 0.63 ± 0.33 μg ml−1 (P 〈 0.05 versus sedentary controls), 8.1 ± 4.0 μg ml−1 (P 〈 0.01), and 0.52 ± 0.23 mg ml−1 (P 〈 0.05). Corresponding molar values were 0.73 ± 0.37 (UQ), 2.0 ± 1.1 μmol l−1 (αT), and 1.42 ± 0.54 mmol 1−1 (FC). Blood and plasma UQ values were identical. A saturationlike relationship was found between heart and blood UQ: blood contents below 0.7 μg ml−1 (0.8 μmol l−1) corresponded to markedly lowered heart contents. In four patients in whom blood samples were taken close to a fatal complication it averaged 0.42 μg ml−1 (0.49 μmol l−t, P 〈 0.01). When low heart muscle and blood ubiquinone were present, other variables such as left ventricle cardiac output or cycle ergometer performance was markedly impaired. Plasma UQ and off covaried with a marker of the lipoidal deposit volume, plasma FC. The ratios UQ and αT over FC (N-UQ and N-αT) are alternative means for clinical evaluation. Mean N-αT was relatively more depleted than N-UQ. On an individual basis this was more pronounced for those with low N-UQ than for those with high values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226845
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Postoperative analgesic effects of intra-articular bupivacaine and morphine after arthroscopic cruciate ligament surgery (1995)
    Springer
    Knee surgery, sports traumatology, arthroscopy 3 (1995), S. 55-59 
    Details
    ISSN: 1433-7347
    Keywords: Bupivacaine ; Morphine ; Arthroscopy ; Local anaesthetic ; Anterior cruciate ligament
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract Intra-articular administration of local anaesthetics such as bupivacaine can produce short-term postoperative analgesia in patients undergoing diagnostic arthroscopy or arthroscopic meniscectomy. A peripheral anti-nociceptive effect may also be induced by the administration of intra-articular opiates interacting with local opioid receptors in inflamed peripheral tissue. In the present study we aimed to study the analgesic effects of intraarticularly given bupivacaine and morphine sulphate (as well as the combination of both drugs) on postoperative pain. In a prospective, randomized, double-blind manner 40 patients received one of the following: (a) morphine (1 mg in 20 ml NaCl), (b) bupivacaine (20 ml, 0.375%), (c) combination of both or (d) saline (20 ml, control group) intra-articularly at the end of arthroscopic anterior cruciate ligament (ACL) reconstruction. The postoperative pain was assessed via a visual analogue scale (VAS) during the first 48 h after surgery, and supplemental analgesic requirements were noted. All comparisons were made versus the control group receiving saline. The pain scores were significantly lower in the morphine group at 24 and 48 h, and in the bupivacaine group at 2, 4 and 6 h after surgery. In the group that received a combination of both bupivacaine and morphine, the pain scores were significantly reduced throughout the whole postoperative observation period. No side-effects or complications from therapy were seen in any of the groups. The conclusion of this study is that intra-articular morphine is effective in the postoperative period after arthroscopic ACL reconstruction. The combination of bupivacaine and morphine was the most effective postoperative analgesic regimen and resulted in significant analgesia throughout the whole 48-h period following surgery. Patients receiving the combination of bupivacaine and morphine had a significantly shorter hospital stay than the control group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01553527
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Closing patellar tendon defects after anterior cruciate ligament reconstruction: absence of any benefit (1998)
    Springer
    Knee surgery, sports traumatology, arthroscopy 6 (1998), S. 82-87 
    Details
    ISSN: 1433-7347
    Keywords: Key words Patellar tendon defects ; Donar site morbidity ; Anterior ; cruciate ligament reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract The most common graft in anterior cruciate ligament (ACL) surgery involves using the central one-third of the patellar tendon. Knowledge concerning the postoperative disability after harvesting the patellar tendon is, however, limited. The aim of this study was to evaluate the impact patellar tendon suture and bone grafting of the patellar bone defect might have in terms of functional outcome and patellofemoral pain after harvesting the bone-tendon-bone graft, compared with leaving the harvested site non-sutured and non-grafted. Sixty patients, scheduled for arthroscopically assisted ACL reconstruction, were randomly allocated to two groups. In group I, suture of the patellar tendon and bone grafting of the patellar defect were performed. In group II, the tendon gap and the patellar defect were left open. Preoperatively, there was no significant difference between the groups when comparing objective knee stability, as measured with a KT-1000 laxity meter, Lysholm score, Tegner activity level, IKDC score, or patellofemoral pain score. Both groups had a significantly improved Lysholm score at the 2-year follow-up, without any difference between them. Tegner's activity level was significantly lower at follow-up, compared with the pre-injury level in both groups. The patellofemoral pain score improved significantly after the reconstruction, without any difference between the groups. Ultrasonography did not reveal any difference between the groups in terms of healing of the tendon gap. This study revealed no differences in donor site morbidity, functional outcome, patellofemoral pain score or knee joint stability between the two treatment groups. The conclusion is that suture of the patellar tendon and bone grafting of the patellar defect do not improve the functional results or reduce donor site morbidity after arthroscopically assisted ACL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001670050077
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    Paper (German National Licenses)
    Fulltext
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