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  • 1
    Electronic Resource
    Electronic Resource
    Heart muscle ubiquinone and plasma antioxidants following cardiac transplantation (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. S76 
    Details
    ISSN: 1432-1440
    Keywords: Heart transplantation ; Heart ubiquinone ; Blood and plasma ubiquinone ; Plasma α-tocopherol ; Transplant rejection ; Free radicals ; Antioxidants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nine patients who underwent heart transplantation (one female; average age 48 ± 11, range 19–58 years) were followed in respect to contents of right-sided heart septum, blood and plasma ubiquinone (UQ), plasma α-tocopherol (αT), and plasma free cholesterol (FC). In contrast to healthy persons, substantial inter- and intraindividual variations were observed; individually low values were seen with rejection. Heart muscle UQ in well-treated patients averaged 0.33 ± 0.08, range 0.06–0.58 μg mg−1 (0.38 ± 0.09 μmol g−1 dry weight) and was not different from healthy individuals. Plasma UQ, αT; and FC averaged 0.63 ± 0.33 μg ml−1 (P 〈 0.05 versus sedentary controls), 8.1 ± 4.0 μg ml−1 (P 〈 0.01), and 0.52 ± 0.23 mg ml−1 (P 〈 0.05). Corresponding molar values were 0.73 ± 0.37 (UQ), 2.0 ± 1.1 μmol l−1 (αT), and 1.42 ± 0.54 mmol 1−1 (FC). Blood and plasma UQ values were identical. A saturationlike relationship was found between heart and blood UQ: blood contents below 0.7 μg ml−1 (0.8 μmol l−1) corresponded to markedly lowered heart contents. In four patients in whom blood samples were taken close to a fatal complication it averaged 0.42 μg ml−1 (0.49 μmol l−t, P 〈 0.01). When low heart muscle and blood ubiquinone were present, other variables such as left ventricle cardiac output or cycle ergometer performance was markedly impaired. Plasma UQ and off covaried with a marker of the lipoidal deposit volume, plasma FC. The ratios UQ and αT over FC (N-UQ and N-αT) are alternative means for clinical evaluation. Mean N-αT was relatively more depleted than N-UQ. On an individual basis this was more pronounced for those with low N-UQ than for those with high values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226845
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Echocardiographic assessment of cardiac function and morphology in patients with generalised lipodystrophy (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 355-359 
    Details
    ISSN: 1432-1076
    Keywords: Lipodystrophy ; Echocardiography ; Cardiac function ; Wall motion analysis ; Cardiomyopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because cardiomegaly has been observed in lipodystrophic patients we studied cardiac morphology and function with one- and two-dimensional echocardiography in addition to general cardiologic examination in a series of seven patients. Muscular hypertrophy with increased chamber size and myocardial indentations were found. Two patients had asymmetrical septal hypertrophy (ASH), and two patients demonstrated systolic anterior movement (SAM) of the mitral valve. Wall motion analysis showed anomalities in four patients during contraction, in three during the early relaxation phase. Since pathological findings, probably increasing with age, were made in the majority of the patients, these findings add an additional unfavourable aspect to the syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441777
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Dilution and hemolysis causing anaemia after artificial heart implantation (1987)
    Springer
    Annals of hematology 54 (1987), S. 127-128 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321044
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Vitamins Q and E, extracorporal circulation and hemolysis (1997)
    Springer
    Molecular and cellular biochemistry 173 (1997), S. 33-41 
    Details
    ISSN: 1573-4919
    Keywords: blood andplasma vitamin Q ; ubiquinone ; coenzyme Q10 ; CoQ10 ; plasma vitamin E ; a-tocopherol ; antioxidants ; oxygen burst ; free radicals ; membrane trauma ; erythrocyte ; hemolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Whole blood vitamin Q (ubiquinone), plasma vitamins Q and E(alpha-(a-)tocopherol) and free cholesterol (FC) were studied before(control or base-line value, sample I) and during open chest surgery andextracorporal circulation (samples II-IV) in 10 male IHD patients. Identityexisted between control whole blood and plasma ubiquinone. During surgery anincreased discrepancy with lower plasma vitamin Q levels were seen. Controlplasma vitamins Q, E and FC averaged 0.88 ± 0.16 (SE), 12.1 ±2.2 mg × 1-1 and 0.75 ± 0.15 g × 1-1. Corresponding molarvalues were 1.02 ± 0.17, 28.1 ± 5.1 µmol × 1-1 and1.94 ± 0.74 mmol × 1-1. Vitamin Q and E decreased continuouslyand averaged 0.64 mg × 1-1 in sample IV (0.74 µmol × 1-1,p 〈 0.001) and 9.4 mg × 1-1 in sample III (21.8 µmol ×1-1, p 〈 0.001). Hemolysis in all sample IV vials, ruined all vitamin Edeterminations. When normalized for FC (NQ and NE), decreases were found tobe 17 (IV) and 12% (III), respectively. Large interindividual variationsexisted. High control NQ and NE values allowed a larger antioxidant vitamindepletion. High NQ seemed also to be a prerequisite for NE depletion. Inaddition, signs indicated an active liver vitamin Q release for patientsrich in control antioxidant values. It was suggested that the antioxidantvitamin depletion did not prevent from radical trauma to membrane structurallipids (especially omega-3 fatty acids or vitamin F1), less membranefluidity, erythrocyte fragility and hemolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006874923181
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    Paper (German National Licenses)
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