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  • 1
    Electronic Resource
    Electronic Resource
    Immunoelectron microscopic study of γ-aminobutyric acid inputs to identified thalamocortical projection neurons in the anterior thalamus of the rat (1999)
    Springer
    Experimental brain research 126 (1999), S. 369-382 
    Details
    ISSN: 1432-1106
    Keywords: Key words Anterodorsal thalamic nucleus ; Anteroventral thalamic nucleus ; Retrograde labelling ; Postembedding immunoelectron microscopy ; Inhibitory synapses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We have carried out a semi-quantitative ultrastructural study to determine the characteristics and distribution of γ-aminobutyric acid (GABA)-containing constituents of the anterodorsal (AD) and anteroventral (AV) thalamic nuclei in adult rats. We used a polyclonal antibody to GABA and a postembedding immunogold detection method in animals in which the cortical projection neurons of these nuclei had been labelled by retrograde transport of cholera toxin/horseradish peroxidase (HRP) injected into the retrosplenial granular cortex. Two types of GABA-immunopositive structures were identified, with gold particle densities 4–40 times higher than the highest densities over blood-vessel lumens and areas of empty resin: (1) an apparently homogeneous population of axon terminals with Gray type-2 (symmetric) synaptic contacts corresponding to F-axon terminals; and (2) small–medium sized myelinated axons scattered individually or in small groups within the neuropil which may be their parent axons. These axons and terminals may originate from the ipsilateral thalamic reticular nucleus; others may arise from the basal forebrain or brainstem. The GABA-immunopositive terminals comprised approximately 16% of all axon terminal profiles in AD and 12% in AV, a significant difference. However, because the immunoreactive axon terminals in AD were significantly larger than those in AV (1.09±0.47 µm2 vs 0.90±0.43 µm2) and would therefore be encountered more frequently, it is not possible to conclude that the GABAergic innervation of AD is heavier than that of AV. The GABA-positive terminals established synaptic contacts with cell bodies and dendrites of all sizes (some of which were HRP-labelled) with the following frequency distribution (AD/AV, no significant difference): somata 5%/7%; large dendrites (≥1.5 µm) 14%/9%; medium dendrites (1.00–1.49 µm) 35%/45% and small dendrites (〈1 µm) 46%/40%. Despite evidence from previous studies, we found no evidence in this study for the presence of GABAergic interneurons or for GABA-containing projection neurons in AD or AV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050744
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Microtubule fascicles in the stem processes of cultured sensory ganglion cells (1976)
    Springer
    Cell & tissue research 169 (1976), S. 41-47 
    Details
    ISSN: 1432-0878
    Keywords: Dorsal root ganglia ; Tissue culture ; Microtubules ; Axons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Microtubule fascicles, resembling those characterizing the initial segment of multipolar neurons, have been observed by electron microscopy within and close to the origin of the stem process of some unipolar ganglion cells in explant cultures of embryonic chick dorsal root ganglia. Each fascicle comprised 2–6 closely spaced parallel microtubules linked by electron dense cross-bridges. Since similar observations have been made on stem processes in vivo, the possibility that linked microtubules occur commonly in this site is considered. The observations are discussed in relation to a possible correlation between the presence of microtubule fascicles and the initiation of action potentials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219306
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Microtubule-associated smooth endoplasmic reticulum in the frog's brain (1971)
    Springer
    Cell & tissue research 116 (1971), S. 564-577 
    Details
    ISSN: 1432-0878
    Keywords: Axons ; Dendrites ; Microtubules ; Endoplasmic Reticulum ; Synapses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electron microscopic studies of neural processes in the cerebellum, optic tectum, and cerebral hemisphere of the frog reveal a distinctive system of SER cisternae lying at intervals (commonly 1–2 μm apart) perpendicular to the long axis of axons and dendrites, interconnected by tubular, longitudinally orientated SER elements, and in direct continuity with the outer membrane of mitochondria. The transverse cisternae are fenestrated, with a single mierotubule (or rarely, two) passing through the centre of each 50–75 nm fenestration. Extensions of the SER-microtubule complex may be located parasynaptically in axon terminals and dendrites. The SER of dendritic spines also appears to be continuous with the fenestrated cisternae. Possible roles for the specialized SER (particularly of the parasynaptic extensions), such as calcium ion sequestration and ATP or monoamine oxidase transport, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335058
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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