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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 140 (1983), S. 47-50 
    ISSN: 1432-1076
    Keywords: Human growth hormone ; Lymphoproliferation ; Phytohaemagglutinin ; Anti-hGH-Antiserum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was designed to investigate the capacity of human growth hormone (hGH) to induce proliferation of human peripheral blood lymphocytes (PBL) and its effect on lectin-induced lymphoproliferation, as measured by [3H]-thymidine (3H-TdR) incorporation into lymphocyte DNA. We observed that hGH itself induced lymphoproliferation. Maximal responses were reached with 50 ng/ml after 4 days and 25 ng/ml after 7 days. Anti-hGH-antiserum completely blocked the stimulatory capacity of hGH. Further evidence for the specificity of the effect was obtained by the finding that no other hormone present in the hGH preparation produced any effect on lymphocyte cultures. In contrast to its stimulatory capacity, hGH reduced the proliferative response of PBL to phytohaemagglutinin (PHA). This effect was also neutralized by anti-hgH-antiserum. These results show a direct stimulatory effect of hGH on PBL and a regulatory effect of the hormone on lectin-induced lymphoproliferation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 119 (1975), S. 161-167 
    ISSN: 1432-1076
    Keywords: Autoimmune hemolytic anemia ; Interstitial nephritis ; Renal biopsy ; Corticosteroid therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über einen 15jährigen Jungen mit autoimmunhämolytischer Anämie vom chronischen Typ berichtet, bei dem sich 3 Jahre nach einer Milzexstirpation eine Niereninsuffizienz entwickelte. Durch eine percutane Nierenbiopsie konnte eine interstitielle Nephritis mit auffallend starken lymphocytären Infiltrationen und verödeten Glomeruli nachgewiesen werden. Die Niereninsuffizienz verschwand unter Steroiden. Die Nierenveränderungen scheinen Ausdruck der Immunerkrankung zu sein.
    Notes: Abstract A case is reported of a 15-year-old boy with chronic autoimmune hemolytic anemia who developed renal insufficiency 3 years after splenectomy. An interstitial nephritis with striking lymphocytic infiltrates and sclerosed glomeruli could be demonstrated by percutaneous renal biopsy. Renal symptoms disappeared promptly after corticosteroid therapy. The renal lesions are thought to have arisen as part of the autoimmune disease.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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