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  • Chemistry  (6)
  • diabetic retinopathy  (3)
  • Anti-serotonin antibodies  (2)
  • [abr] MMH; Methylmercury Hydroxide  (2)
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Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The effects of methylmercury on protein synthesis in rat liver
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 44 (1971), S. 1552-1558 
    Details
    ISSN: 0006-291X
    Keywords: [abr] MMH; Methylmercury Hydroxide ; [abr] PMS; Post-Mitochondrial Supernatant ; [abr] RER; Rough Endoplasmic Reticulum ; [abr] RNA; Ribonucleic Acid ; [abr] SER; Smooth Endoplasmic Reticulum ; [abr] TLH; Total Liver Homogenate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(71)80263-2
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of methylmercury on protein synthesis in rat liver
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 44 (1971), S. 1552-1558 
    Details
    ISSN: 0006-291X
    Keywords: [abr] MMH; Methylmercury Hydroxide ; [abr] PMS; Post-Mitochondrial Supernatant ; [abr] RER; Rough Endoplasmic Reticulum ; [abr] RNA; Ribonucleic Acid ; [abr] SER; Smooth Endoplasmic Reticulum ; [abr] TLH; Total Liver Homogenate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(71)80263-2
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinophilia-myalgia syndrome (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 541-549 
    Details
    ISSN: 1432-1440
    Keywords: Eosinophilia myalgia syndrome ; Fibromyalgia syndrome ; Anti-serotonin antibodies ; Anti-ganglioside antibodies ; Anti-phospholipid antibodies ; Anti-nucleolar antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eosinophilia myalgia syndrome (EMS) has been related to intake of “contaminated” L-tryptophan, and an alteration in tryptophan 5-hydroxytryptamine (5-HT, serotonin) metabolism has been reported in EMS patients. Recently we found that a defined autoantibody pattern consisting of antibodies to nucleoli, gangliosides, and phospholipids is closely related to the fibromyalgia syndrome (FS) which clinically resembles the EMS. We were therefore interested to see whether these antibodies can also be detected in patients with EMS. Studied were 27 patients with acute EMS (13 of whom were also examined 2 years after acute onset), 100 patients with FS, and 40 patients with progressive systemic sclerosis (PSS). As controls, sera from 100 blood donors were analyzed. Antibodies to nucleoli were demonstrated by immunofluorescence test on cell cultures in 52% of patients with acute EMS, 62% of patients with chronic EMS, and 37% of FS patients. Western blotting with a nuclear extract from HeLa cells revealed in both diseases the same epitopes at 63, 57, and 53 kDa. Antibodies to 5-HT, gangliosides (Gm1), and phospholipids were determined by enzyme-linked immunosorbent assay. Among patients with FS 73% had antibodies to 5-HT, in contrast to only 19% of patients with acute EMS. However, 77% of the 13 EMS patients analyzed 2 years later had become anti-5-HT antibody positive during that time. Also the incidence of antibodies to Gm1 increased from 37% at acute onset to 69% in patients with chronic EMS (30%). The various antibodies were detected in only 18% of healthy controls. Serum 5-HT levels were decreased in patients with acute EMS compared to those with chronic EMS or FS. In patients with PSS they were significantly increased. It is concluded that EMS may have been developed in patients with FS who may have reacted in an allergic manner to a more immunogenic (“contaminated”) L-tryptophan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207485
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  • 4
    Electronic Resource
    Electronic Resource
    Methodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM Complications Study (1995)
    Springer
    Diabetologia 38 (1995), S. 437-444 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes ; diabetic retinopathy ; retinal photography ; grading scheme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present the methodology for 45
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410281
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Methodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM Complications Study (1995)
    Springer
    Diabetologia 38 (1995), S. 437-444 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin-dependent diabetes ; diabetic retinopathy ; retinal photography ; grading scheme.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present the methodology for 45° retinal photography and detail the development, application and validation of a new system of 45° field grading standards for the assessment of diabetic retinopathy. The systems were developed for the EURODIAB IDDM Complications Study, part of a European Community funded Concerted Action Programme into the epidemiology and prevention of diabetes (EURODIAB). Assessment of diabetic retinopathy was carried out centrally by a trained reader of colour retinal photographs using the newly-developed system. The system proved to be acceptably accurate, repeatable and relatively simple to apply. It compared well with the recognised ’gold standard' 7-field 30° stereo photography (assessed using a modified Airlie House classification scheme), against which the new system was validated in a series of 48 eyes. Selection was as a stratified random sample based on clinical retinopathy status: 5, no retinopathy; 25, non-proliferative retinopathy; 16, proliferative or photocoagulated; plus 2, eyes with potentially confounding lesions (vein occlusion). Simple presence of retinal lesions was correctly detected by both systems in 43 of the 48 eyes, giving 100 % agreement on detection. Both systems correctly identified the two known cases of confounding vein occlusion. In eyes with diabetic retinopathy (n = 41), when severity was expressed in three groups: mild background, moderate/severe background and proliferative/photocoagulated, at least one grader (out of five) using the new system matched the verified results in 38 out of 41 (93 %) eyes and three or more graders matched in 31 (76 %) eyes. Individually the five graders' 2-field allocations agreed well with the verified levels (median number of agreements 37, range 28–43). Repeatability was assessed by measures of within and between observer variation using randomly selected samples of 10 % (n = 252 eyes) and 5 % (n = 123 eyes) of the main study, respectively, expressed as a resultant kappa value for chance-corrected proportional agreement. Within observer assessment yielded a kappa of 0.85 and between observers a value of 0.83; indicating very good agreement for both measures. The method is particularly useful for large epidemiological studies, in which participating centres have a limited experience in retinal photography. [Diabetologia (1995) 38: 437–444]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410281
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  • 6
    Electronic Resource
    Electronic Resource
    Glycated haemoglobin, plasma glucose and diabetic retinopathy: cross-sectional and prospective analyses (1993)
    Springer
    Diabetologia 36 (1993), S. 428-432 
    Details
    ISSN: 1432-0428
    Keywords: Glycated haemoglobin A1 ; plasma glucose ; diabetic retinopathy ; risk factor ; receiver operating characteristic (ROC) analysis ; Pima Indians
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus the relationships between glycated haemoglobin (HbA1), fasting or 2-h post-load plasma glucose and diabetic retinopathy were examined by cross-sectional and prospective analyses, and the strengths of the associations were directly compared by receiver operating characteristic analysis. In the cross-sectional analysis, HbA1, fasting and 2-h plasma glucose were each significantly related to retinopathy among 789 diabetic subjects by separate logistic models. In a stepwise multiple logistic model in which HbA1, fasting and 2-h plasma glucose were included, HbA1 was selected as having the strongest association with retinopathy and neither fasting nor 2-h plasma glucose contributed significantly to the model once HbA1 was entered. Similarly, in the prospective analysis, HbA1, fasting and 2-h plasma glucose all predicted retinopathy in 227 diabetic subjects by separate proportional-hazards models. In a stepwise proportional-hazards model with HbA1, fasting and 2-h plasma glucose available to the model, HbA1 was again selected as having the strongest association with the incidence of retinopathy, and neither fasting nor 2-h plasma glucose significantly added to the prediction of retinopathy. A receiver operating characteristic analysis was used to determine if HbA1 was statistically significantly better than fasting or 2-h plasma glucose in assessing the risk for retinopathy. In neither the cross-sectional nor the prospective data did the area under the receiver operating characteristic curve for HbA1 differ significantly from that for fasting or 2-h plasma glucose (p〉0.05 for each). In conclusion, HbA1, an integrated measure of blood glucose concentration over a period of 2–3 months, is slightly more closely associated with the prevalence and incidence of diabetic retinopathy than a single blood glucose determination. However, the differences between HbA1 and fasting or 2-h plasma glucose in assessing the association with or the risk for retinopathy are not significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402279
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    A randomised double-blind 16-week study of ritanserin in fibromyalgia syndrome: Clinical outcome and analysis of autoantibodies to serotonin, gangliosides and phospholipids (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 89-94 
    Details
    ISSN: 1434-9949
    Keywords: Anti-ganglioside antibodies ; Anti-phospholipid antibodies ; Anti-serotonin antibodies ; Fibromyalgia syndrome ; 5-HT-receptor blocker ; Ritanserin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to evaluate in a double-blind manner the effect of the long-acting 5-hydroxytryptamine 2 (5-HT2)-receptor blocker Ritanserin on clinical symptoms in patients with fibromyalgia syndrome (FM) and on production of antibodies to serotonin, gangliosides and phospholipids, recently shown to have a high incidence in this disease. Fifty-one female patients with typical FM were included in the 16-week study: 24 received Ritanserin and 27 received a placebo. Antibodies to 5-HT, gangliosides (Gm1) and phospholipids (thromboplastin) were determined by enzyme-linked immunosorbent assay at day 0 and at the end of week 16. The psychological and physical status, including tender points, of the patients was evaluated at day 0 and at the end of weeks 4 and 16. At the end of the study, there was an improvement (p〈0.05) in feeling refreshed in the morning in the Ritanserin-treated group and headache was also significantly improved compared with the placebo group. There was no difference in pain, fatigue, sleep, morning stiffness, anxiety and tender point counts in the Ritanserin and placebo groups. Fifty-one per cent of the 51 patients had at least one of the three antibodies to 5-HT, Gm1 and phospholipids. The incidence and activity of these antibodies were not influenced by Ritanserin or placebo. The observation that Ritanserin has only a small effect on clinical symptoms indicates that disturbances in serotonin metabolism or uptake may be only one factor in the pathogenesis of the disease. The high incidence of a defined autoantibody pattern in FM could again be confirmed in this study. However, it remains speculative whether immunological reactions are, indeed, involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01452251
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  • 8
    Electronic Resource
    Electronic Resource
    Ein verbessertes Huygens-Manometer (1951)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 23 (1951), S. 564-565 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Beim einseitig geschlossenen Huygens-Manometer konnte bisher keine lineare Abhängigkeit zwischen Druck- und Skalenteilen erreicht werden. Durch Anbringen eines Birnengeräßes am Kapillarende wurde das Manometer soweit verbessert, daß man eine völlig lineare Eichkurve erhält.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330232303
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  • 9
    Electronic Resource
    Electronic Resource
    Die Temperaturabhängigkeit einiger elastischer Eigenschaften im Erweichungsintervall der Gläser (1930)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 192 (1930), S. 161-178 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19301920112
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Experimental heats of mixing for gaseous nitrogen and methane (1971)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 17 (1971), S. 958-965 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The excess enthalpy of binary gas phase mixtures has been measured by direct experiment, using a continuous flow, isothermal colorimeter. Heat of mixing data are presented for the methane-nitrogen system for compositions of 25 to 80 mole % methane in nitrogen, at temperatures of 40°, 0°, -20°, -40°, -60°, and -78°C. and pressures from 250 to 1,50 lb./sq. in. abs. These data are in agreement with the literature to within the experimental uncertainty of this work, 4%.The experimental results agree well with values predicted using the Benedict-Webb-Rubin and the Redlich-Kwong equations of state. The virial equation of state truncated after the third coefficient fits the low density data only. The liquid theories of Scott predict the enthalpies of the mixtures in a qualitative way.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690170432
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