Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Chronic active hepatitis  (2)
  • Hepatitis B virus  (2)
  • Antibodies  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Modification of the immune response against hepatitis B virus by the human immunodeficiency virus (1989)
    Springer
    Rheumatology international 9 (1989), S. 175-179 
    Details
    ISSN: 1437-160X
    Keywords: Hepatitis B virus ; Human immunodeficiency virus ; Interferon alpha ; Chronic hepatitis ; Hepatitis B ; Vaccination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hepatitis B virus and the human immunodeficiency virus are similarly transmitted. Individuals with preexisting HIV infection have a higher chance to become HBsAg carriers than do anti-HIV negative persons. Cytotoxic T cells with specificity for HBcAg, that are under the control of HBcAg-specific helper T cells, are responsible for liver injury. There is good evidence that HIV infection lowers inflammatory activity, is associated with milder liver histology, high levels of viral replication and low seroconversion rates. In addition interferon alpha therapy is less effective in anti-HIV positive subjects. The immune response against HBsAg is helper T-cell dependent and vaccination against hepatitis B is of low effectiveness. In addition, vaccination against hepatitis B may activate the HIV disease and is, therefore, presently not to be recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271876
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Correlation of anti-cytoskeleton antibody activities in synovial fluid with interleukin-6 in patients with osteoarthritis and inflammatory joint disease (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 685-691 
    Details
    ISSN: 1432-1440
    Keywords: Synovial fluid ; IL-6 ; Cytoskeleton ; Antibodies ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Synovial fluids and sera from patients with rheumatoid arthritis, psoriatic arthritis, yersinia arthritis, Behçet's syndrome, Crohn's disease, and osteoarthritis were tested for antinuclear antibodies and antibodies to five cytoskeletal components in sensitive enzyme-linked immunosorbent assay (ELISA) systems and for IL-6 concentrations in a proliferation assay (IL-6 dependent hybridoma cell line B13.29, subclone B9). Statistically significant correlations between antibody activities and IL-6 levels were found for vimentin antibodies (r= 0.56; p〈0.05) and actin antibodies (r= 0.44;p〈0.05). In patients with chronic and active disease like rheumatoid arthritis and psoriatic arthritis, optical densities measured by vimentin- and actin-ELISA were significantly different from those measured in patients with osteoarthritis. To date only a few reports exist concerning the incidence of antibodies in synovial fluids. We have shown to our knowledge for the first time that IL-6 seems to induce synovial fluid antibody activities restricted to cytoskeletal components of synoviocytes (i.e., vimentin and actin). Synovial fluid antibody activities against vimentin and actin appear to be markers of activity in patients with inflammatory joint disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01667017
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infection (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 1030-1036 
    Details
    ISSN: 1432-1440
    Keywords: Human immunodeficiency virus ; Hepatitis B virus ; Interferon-α ; Corticosteroid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 48-year-old male patient was admitted with acquired immunodeficiency syndrome (stage III, Centers for Disease Control 1993) and viremic hepatitis B. Blood CD4 count was 15/μl. Discontinuation of prednisolone, previously prescribed by the patient's family practitioner because of elevated liver enzymes, resulted in severe hepatitis (alanine aminotransferase 〉 300U/1). Administration of interferon-α, (9 × 106U s.c. 3 × weekly) was initiated. Serum markers of viral replication disappeared, and aminotransferase levels returned to normal within a few weeks. The patient's serum was found negative for HBsAg after 3 months. Immunohistochemical analysis of liver biopsies before and during interferon therapy showed disappearance of all hepatitis B virus antigens and a marked reduction in inflammatory activity. Hepatitis B virus seroconversion remained stable until the patient died from the syndrome 2 years later. This case shows that in spite of severe HIV-associated immune deficiency with CD4 counts constantly below 100/μl, interferon-α can lead to sustained serological and histological improvement of viremic hepatitis B. Previous administration and discontinuation of cortisone may have helped to reach this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577750
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Celluläre Immunreaktionen gegenüber homologen leberspezifischen Antigenen (HLP) bei chronischen Leberentzündungen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 246-248 
    Details
    ISSN: 1432-1440
    Keywords: Chronic active hepatitis ; Cellular immunity ; Liver specific antigens ; Migration inhibition test ; leukocyte ; Chronisch aktive Hepatitis ; Celluläre Immunität ; Leberspezifische Antigene ; Migrations-Inhibitions-Test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine Zweiphasentechnik des Leukocyten-Migrations-Inhibitionstestes beschrieben und zum Nachweis einer cellulären Immunreaktion gegenüber Leberantigenen bei chronisch-entzündlichen Lebererkrankungen eingesetzt. Mit dieser Technik wurde bei 85% der Patienten mit hypergammaglobulinämischer Verlaufsform einer chronisch-aktiven Hepatitis und 42% der Patienten mit aktiv fortschreitenden kryptogenen Lebercirrhosen eine Migrationshemmung nachgewiesen. Lebergesunde Kontrollen zeigten keine, Patienten mit dem Zustand nach Hepatitis und chronisch-persistierender Hepatitis selten eine Leukocytenmigrationsinhibition gegenüber leberspezifischen Antigenen. 17% der Patienten mit chronisch-aktiver Hepatitis, die länger als 6 Monate unter einer immunosuppressiven Therapie standen, ließen noch eine schwache Migrationsinhibition erkennen. Die Befunde legen nahe, daß celluläre Immunreaktionen gegenüber leberspezifischen Antigenen bei bestimmten Verlaufsformen einer chronisch-entzündlichen Lebererkrankung pathogenetisch von Bedeutung sind.
    Notes: Summary A two-phase technique of the leukocyte migration inhibition test is described. Cellular immunity to homologous liver specific proteins in patients with chronic inflammatory liver diseases has been assayed using this test system. Inhibition of migration was observed in 85% of the patients with chronic active hepatitis and in 42% of the patients with cryptogenic cirrhosis of the liver. Healthy subjects with no history of liver disease were used as controls and showed no inhibition of migration to the liver antigens. Patients with healed hepatitis and chronic persistent hepatitis rarely had abnormal migration indices. A statistically insignificant inhibition of migration was found only in patients with chronic active hepatitis treated with azathioprin and prednison. The results support the view of the importance of cell- mediated immune reactions towards liver antigens in the pathogenesis of chronic active hepatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468598
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Histokompatibilitäts-(HLA) Antigene bei Patienten mit HBsAg-positiver und -negativer chronisch aktiver Hepatitis und gesunden Trägern von HBsAg und Anti-HBs (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 579-583 
    Details
    ISSN: 1432-1440
    Keywords: HLA ; Chronic active hepatitis ; Autoimmunity ; HBsAg ; Anti-HBs ; HLA ; Chronisch-aktive Hepatitis ; Autoimmunität ; HBsAg ; Anti-HBs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine Analyse der Literatur und eigene Befunde über die Häufigkeit von 23 HLA-Antigenen bei Patienten mit Hepatitis-Oberflächen-Antigen (HBsAg)-positiver und -negativer chronisch aktiver Hepatitis (CAH) und gesunden Trägern von HBsAg und Antikörpern gegen HBsAg (Anti-HBs) erlauben die folgenden Schlußfolgerungen: 1. Bei Patienten mit CAH und HBsAg-Persistenz findet sich eine normale Häufigkeit von HLA-B8 (und -A1). 2. Auch bei Patienten mit HBsAg-negativen Formen einer CAH ohne Autoimmunphänomene (AutoAk) ist die HLA-B8-Häufigkeit normal. 3. Nur Patienten mit HBsAg-negativer CAH mit AutoAk haben eine statistisch signifikant größere Häufigkeit von HLA-B8 (und -A1) (p 〈 0,01 nach Korrektion für die Zahl der getesteten HLA-Antigene und Patientengruppen). 4. Es bestehen keine signifikanten Unterschiede in der Häufigkeit der getesteten HLA-Antigene bei CAH-Patienten mit HBsAg-Persistenz und gesunden Trägern von HBsAg und Anti-HBs. Somit konnten keine Hinweise für HLA-assoziierte Faktoren für das unterschiedliche Verhalten gegen das Hepatitis-B-Virus gefunden werden.
    Notes: Summary New own data and a survey of published data concerning the frequencies of 23 HLA antigens in patients with HBsAg positive and negative chronic active hepatitis (CAH) and healthy carriers of Hepatitis-surface antigen (HBsAg) and high titers of antibodies to HBsAg (Anti-HBs) allow to conclude as follows: 1. Patients with CAH and persistence of HBsAg show a normal frequency of HLA-B8 2. There is no increased frequency of HLA-B8 in HBsAg negative CAH without autoimmune antibodies. 3. Only in patients with HBsAg negative CAH with autoimmune antibodies is the frequency of HLA-B8 is statistically significantly increased (p 〈 0.01 after correction for the number of antigens and different groups of patients compared). These are patients with the autoimmune form of CAH. 4. There exist no significant differences in the frequencies of the HLA antigens tested in patients with HBsAg positive CAH and healthy carriers of HBsAg and Anti-HBs. Thus no indications could be found for HLA-associated factors in the different behaviour to the hepatitis-B virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01619573
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...