Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Schizophrenia  (3)
  • prolactin  (3)
  • Creatine Phosphokinase  (2)
  • Antipsychotic  (1)
  • Antipsychotic drugs  (1)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat (1987)
    Springer
    Journal of neural transmission 68 (1987), S. 227-240 
    Details
    ISSN: 1435-1463
    Keywords: Neuroleptics ; dopamine ; prolactin ; hypothalamus ; clozapine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two atypical neuroleptic agents, clozapine and fluperlapine, produced rapid elevations in plasma PRL concentrations that were similar in magnitude to those produced by haloperidol. However, the PRL response to clozapine or fluperlapine was of much shorter duration than that elicited by haloperidol. Clozapine, but neither fluperlapine nor haloperidol, produced a rapid increase in the activity of tuberoinfundibular dopamine (TIDA) neurons, as evidenced by an enhanced accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after the inhibition of DOPA decarboxylase. The clozapine-induced increase in DOPA accumulation was evident within 30 minutes after its administration and persisted for at least 4 hours. The clozapine-induced increase in the activity of TIDA neurons may account, in part, for the abbreviated PRL response to this neuroleptic. In addition, ability to produce a short-lived increase in PRL secretion in the rat appears to be common to the atypicl neuroleptic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02098500
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of 8-hydroxy-2-(di-n-propylamino) tetralin on rat prolactin secretion (1984)
    Springer
    Journal of neural transmission 59 (1984), S. 143-149 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine agonist ; prolactin ; dopamine receptor ; 5-HT agonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 8-OH-DPAT (8-hydroxy-2-[di-n-propylamino] tetralin) is a novel aminotetralin derivative which has been proposed to be a serotonin (5-HT) agonist devoid of dopamine agonist effects. We now report that the administration of 8-OH-DPAT, like known 5-HT agonists, produced a rapid elevation of serum prolactin concentrations in male rats. The prolactin response to 8-OH-DPAT, like that induced by other 5-HT agonists, was greatly potentiated in animals pretreated with the tryptophan hydroxylase inhibitor, para-chlorophenylalanine. However, the 8-OH-DPAT-induced elevation of serum prolactin cocentrations in untreated rats was not dose-dependent and was modest in magnitude compared to that produced by known 5-HT agonists. In contrast to the stimulatory effects of 8-OH-DPAT on prolactin secretionin vivo 8-OH-DPAT suppressed the secretion of prolactin from anterior pituitary tissuein vitro, and this effect was blocked by haloperidol. The results of the present study are supportive of the view that 8-OH-DPAT has dopamine agonist, as well as 5-HT agonist, properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01255412
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy (1983)
    Springer
    Psychopharmacology 81 (1983), S. 37-41 
    Details
    ISSN: 1432-2072
    Keywords: Bromocriptine ; Dopamine ; Schizophrenia ; Autoreceptor ; Prolactin ; Growth hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bromocriptine (0.5–6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439271
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effects of phencyclidine and stress on plasma creatine phosphokinase (CPK) and aldolase activities in man (1972)
    Springer
    Psychopharmacology 26 (1972), S. 44-53 
    Details
    ISSN: 1432-2072
    Keywords: Phencyclidine ; Stress ; Creatine Phosphokinase ; Aldolase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phencyclidine (Sernyl, Phen) is a potent psychotomimetic drug in man. In conjunction with restraint stress, Phen produces increased plasma creatine phosphokinase (CPK) and aldolase (Ald) activities and skeletal muscle pathology in rats. Increased plasma CPK and Ald activities and skeletal muscle pathology are found in some acutely psychotic patients. It was therefore of interest to determine if Phen increased plasma CPK or Ald levels in man. Four of seven subjects had no elevations of plasma CPK or Ald activity either before or after Phen, 0.1 mg/kg, i.v. One subject had increased CPK levels which began 1 h after Phen. Two subjects had increased Ald and/or CPK levels which began within 24 h before Phen administration and which persisted or increased for at least 24 h after Phen. The plasma enzyme changes occurred in those subjects who showed the most pronounced cognitive disruption after Phen. The effects of stress and Phen on plasma CPK and Ald levels and its implications for the study of muscle abnormalities in psychotic patients are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421917
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine (1996)
    Springer
    Psychopharmacology 124 (1996), S. 176-187 
    Details
    ISSN: 1432-2072
    Keywords: Clozapine ; Schizophrenia ; Serotonin ; Dopamine ; Psychosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to report the effect of the slow withdrawal of clozapine from 19 patients withneuroleptic-responsive schizophrenia at the end of a 2-year clinical trial of clozapine and to compare this with the results of naturalistic discontinuation of clozapine treatment in 64neuroleptic-resistant schizophrenic patients. Nineteen neuroleptic-responsive schizophrenic patients who received clozapine were withdrawn from clozapine by tapering it over 3-week period with and without the addition of a typical neuroleptic. Fifteen of the 19 neuroleptic-responsive patients experienced the return of psychotic symptoms during or after the clozapine taper, which were most severe in the ten patients in whom the withdrawal of clozapine was carried out without prior addition of neuroleptic treatment. Addition of a neuroleptic prior to clozapine withdrawal prevented the emergence of positive symptoms during clozapine withdrawal in each of eight patients. Nevertheless, psychotic symptoms emerged, usually within a week after discontinuing clozapine, in six of the eight patients. Neuroleptic treatment, with or without an anticholingergic drug, was much less effective in treating positive symptoms in these patients immediately after the clozapine withdrawal than it had been 2 years previously. Cyproheptadine, a non-selective serotonin receptor antagonist, augmented the antipsychotic effect of neuroleptics in each of four patients who relapsed following withdrawal from clozapine and relieved extrapyramidal symptoms in a fifth patient. The frequency of relapse following withdrawal of clozapine in 64 neuroleptic-resistant patients was significantly lower (25/64, 39.1%) than in the neuroleptic-responsive patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245619
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs (1995)
    Springer
    Psychopharmacology 120 (1995), S. 365-368 
    Details
    ISSN: 1432-2072
    Keywords: Antipsychotic drugs ; D4 dopamine receptor ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The affinities of 13 atypical and 12 typical antipsychotic drugs for the cloned rat D4 dopamine receptor and the D4/D2 ratios were examined. Of the atypical antipsychotic drugs tested, only clozapine, risperidone, olanzapine, zotepine and tiospirone had affinities less than 20 nM. In fact, many atypical antipsychotic drugs had relatively low affinities for the cloned rat D4 receptor, with Ki values greater than 100 nM (Seroquel, fluperlapine, tenilapine, FG5803 and melperone). Additionally, several typical antipsychotic drugs had high affinities for the cloned rat D4 receptor, with Kis less than 20 nM (loxapine, chlorpromazine, fluphenazine, mesoridazine, thioridazine and trifluoroperazine). The ratios of D2/D4 affinities did not differentiate between these two types of antipsychotic drugs. Thus, D4 dopamine receptor affinity, used as a single measure, does not distinguish between the group of typical and atypical antipsychotic drugs analyzed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02311185
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Perlapine: Relationship between stimulation of prolactin secretion and antipsychotic activity (1977)
    Springer
    Psychopharmacology 54 (1977), S. 183-186 
    Details
    ISSN: 1432-2072
    Keywords: Clozapine ; Clothiapine ; Perlapine ; Loxapine ; Prolactin ; Antipsychotic ; Neuroleptic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Perlapine is a dibenzohetereopine compound chemically related to clothiapine, loxapine, and clozapine. Although the latter three compounds are antipsychotic, perlapine has not been reported to be antipsychotic. Nevertheless, all four drugs increase rat plasma prolactin levels. The order of potency is loxapine, perlapine, clothiapine, and clozapine. These results suggest that either perlapine should be reexamined for antipsychotic properties or there are hitherto unsuspected discrepancies between the dopamine receptors relevant to antipsychotic activity in man and those that regulate prolactin secretion in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426777
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Rigidity, hyperpyrexia and coma following fluphenazine enanthate (1973)
    Springer
    Psychopharmacology 29 (1973), S. 337-346 
    Details
    ISSN: 1432-2072
    Keywords: Fluphenazine Enanthate ; Coma ; Extrapyramidal ; Creatine Phosphokinase ; Hypothalmus ; Neuroleptic “Malignant” Syndrome ; Muscular Figidity ; “Lethal Catatonia” ; Hyperpyrexia ; Malignant Hyperpyrexia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Beginning one day after receiving fluphenazine enanthate (Prolixin Enanthate®), 25 mg, subcutaneously, an acute schizophrenic girl with mixed schizoaffective and excited catatonic symptomatology became mute and withdrawn, then developed severe muscular rigidity and hyperpyrexia, and finally became comatose. The patient developed large increases in serum creatine phosphokinase (CPK) activity by the third day of this syndrome. The previously described symptoms, which have been labeled the neuroloptic “malignant” syndrome (Delay and Deniker, 1968), diminished with supportive treatment and intravenous benztropine mesylate (Cogentin®). Because of renewed psychotic behavior, phenothiazine treatment was eventually restarted, including treatment with fluphenazine enanthate, without recurrence of the extrapyramidal or hypothalamic symptoms. The difficulty in distinguishing between the neuroleptic “malignant” syndrome and Stauder's “acute lethal catatonia” is emphasized. The relationship between these syndromes and malignant hyperpyrexia is discussed. Possible causes of the increased serum CPK activity are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429281
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Plasma-soluble interleukin-2 and transferrin receptor in schizoprenia and major depression (1995)
    Springer
    European archives of psychiatry and clinical neuroscience 244 (1995), S. 325-329 
    Details
    ISSN: 1433-8491
    Keywords: Depression ; Schizophrenia ; Interleukin-1β Interleukin-2 ; Interleukin-6 ; Transferrin receptor ; Psychoimmunology ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was carried out to examine some components of in vivo immune function in major depression and schizophrenia. Toward this end, plasma concentrations of interleukin-1β (IL-1β) and IL-6, soluble IL-2 receptor (sIL-2R), and transferrin receptor (TfR) were measured in 28 normal controls, 11 schizophrenics and 13 major-depressed patients. Schizophrenic and major-depressed patients showed significantly higher plasma sIL-2R and TfR than normal controls. There was a trend toward higher plasma IL-6 in the psychiatric patients, and particularly in schizophrenic patients, than in normal volunteers. In normal controls and in the total study group, there were highly significant and positive correlations between plasma TfR and sIL-2R concentrations. It is suggested that schizophrenia and major depression are characterized by immune disorders that may indicate activation of cell-mediated immunity such as T-cell activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02190412
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Effect of pindolol on hormone secretion and body temperature: Partial agonist effects (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 77-88 
    Details
    ISSN: 1435-1463
    Keywords: Pindolol ; cortisol ; prolactin ; serotonin ; temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pindolol has been shown to be a partial agonist at 5-HT1a receptors in preclinical studies. It has also been reported to inhibit the effects of other 5-HT1a partial agonists such as ipsapirone and buspirone on hormone secretion and body temperature in man, indicating its antagonist action at 5-HT1a receptors in man. To determine if pindolol has 5-HT1a agonist as well as antagonist effects in man, pindolol, 30 mg, p.o. and placebo, were given single blind in random order to 23 normal men with indwelling venous catheters and its effects on hormone secretion and body temperature noted. Pindolol significantly increased basal plasma cortisol concentrations, whereas it decreased plasma prolactin (PRL) concentrations and body temperature. The increase in plasma cortisol due to pindolol suggests a 5-HT1a agonist action and is consistent with a 5-HT1a partial agonist mechanism in man whereas the PRL effects are consistent with an antagonist action at 5-HT1a receptors. The effects of pindolol on plasma cortisol concentration and body temperature were significantly negatively correlated. Furthermore, these results indicate significant differences in the 5-HT1a -dependent regulation of PRL and the hypothalamo-pituitary-adrenal (HPA) axis and body temperature, and suggest that human basal PRL secretion is tonically stimulated by a 5-HT1a mechanism whereas the HPA axis and body temperature are not. Since rodent studies suggest differences in 5-HT1a receptor sensitivity between males and females, the results reported here need to be replicated in females. These differences in the effect of pindolol are discussed in terms of receptor reserve theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292618
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...