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  • Apomorphine  (2)
  • stereotypy  (2)
  • 1
    Electronic Resource
    Electronic Resource
    The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior (1992)
    Springer
    Journal of neural transmission 87 (1992), S. 23-35 
    Details
    ISSN: 1435-1463
    Keywords: NMDA receptor ; locomotion ; catalepsy ; stereotypy ; rat ; CGP 37849 ; dizocilpine (MK-801) ; glycine ; D-cycloserine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of competitive (CGP 37849 and CGP 39551) and noncompetitive (dizocilpine) N-methyl-D-aspartate (NMDA) antagonists were tested in three animal models (catalepsy, sniffing, locomotion) and, in addition, the modulation of these effects by an agonist of the strychnine-insensitive glycine binding site was investigated. Both competitive and non-competitive NMDA antagonists reduced neuroleptic-induced catalepsy. Weak sniffing was induced by the competitive antagonist but strong sniffing by the non-competitive NMDA antagonist. Due to muscle relaxation the competitive antagonist reduced locomotion, in contrast to stimulation of locomotor activity induced by the noncompetitive NMDA antagonist. The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253108
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Involvement of dopaminergic neurotransmission in the control of goal-directed movements (1983)
    Springer
    Psychopharmacology 80 (1983), S. 360-364 
    Details
    ISSN: 1432-2072
    Keywords: Predatory behavior ; Neuroleptics ; Apomorphine ; Bromocriptine ; Dopamine receptors ; Ferret
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes produced in dopamine (DA) activity, by administration of the DA-antagonists metoclopramide (10 mg/kg IM) and tiapride (16 mg/kg IM) and of the DA agonists apomorphine (0.5 and 1 mg/kg IM) and bromocriptine (8 mg/kg orally), specifically modified predatory behavior in the ferret. Sulpiride (40 mg/kg IP and 90 mg/kg IM) did not change the behavior. The number of bites necessary to kill the prey was reduced by metoclopramide and tiapride. The number of bites after the death of the prey was not changed. The latency from the first bite to the death of the prey was shortened. Apomorphine and bromocriptine increased the number of bites. The DA receptor blockers haloperidol, chlorpromazine, and clozapine had similar effects to metoclopramide and tiapride, and the DA agonist l-dopa had similar effects to apomorphine and bromocriptine. The pattern of results indicated that, considering the two major DA receptor types, D-2 receptors or D-2 in combination with D-1 but not D-1 receptors alone were involved in the control of goal-directed movements. The results also provided some evidence that blockade of these DA receptors caused a narrowing of the range of exhibited behavioral responses. Stimulation of these DA receptors had opposite effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432121
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Haloperidol- and apomorphine-induced changes in pup searching behaviour of house mice (1988)
    Springer
    Psychopharmacology 95 (1988), S. 271-275 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine ; Maternal behaviour ; Response-switching ; Apomorphine ; Haloperidol ; House mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which is adequate to activate species specific pup searching behaviour or towards a 20 kHz tone (neutral stimulus), thus showing her preference for one of these stimuli. Under apomorphine (0.00625; 0.0125; 0.025 mg/kg) the females preferred the key stimulus. Nevertheless apomorphine (0.00625–0.025 mg/kg) prolonged response latencies and shortened the duration of pup searching. At the highest dose (0.05 mg/kg), apomorphine induced stereotyped sniffing. Haloperidol (0.025; 0.05; 0.1 mg/kg) had opposite effects to apomorphine: it lowered the threshold for elicitation, shortened response latencies and prolonged the duration of pup searching. Females treated with haloperidol (0.025–0.1 mg/kg) did not prefer the key stimulus. Changes in response elicitation and in the performance of pup searching induced by apomorphine and haloperidol, respectively, were assumed to be due to i) a reduced and an increased responsiveness to external stimuli respectively, ii) an enhanced and a reduced tendency for response switching respectively, and iii) a preference for spontaneous behaviour in apomorphine-treated females, with an increased dependence on exteroceptive stimuli following haloperidol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174523
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    MK-801-induced stereotypy and its antagonism by neuroleptic drugs (1990)
    Springer
    Journal of neural transmission 81 (1990), S. 173-182 
    Details
    ISSN: 1435-1463
    Keywords: NMDA-receptor ; MK-801 ; haloperidol ; clozapine ; stereotypy ; sniffing ; locomotion ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo-(a,d)cyclo-hepten-5, 10-imine hydrogen maleate], which blocks glutamatergic transmission at the NMDA-receptor-gated ion chanel, induced stereotypies which are similar to those found after intrastriatal injections of AP-5, e.g. sniffing and locomotion. Tests in familiar or unfamiliar environment (non-stressful or stressful situation) did not qualitatively change MK-801-induced effects. Haloperidol (0.1mg/kg, IP) delayed the onset and shortened the duration of MK-801 (0.16; 0.33mg/ kg, IP)-induced stereotypy whereas clozapine (5 mg/kg, SC) potently antagonized it. However, exact quantification of sniffing, measured in an experimental chamber designed for this purpose, revealed an antagonism by both drugs, haloperidol as well as clozapine. Stereotypy is considered to represent an animal model of schizophrenia, and the antagonism of stereotypy with classical (haloperidol) as well as with atypical (clozapine) antipsychotic drugs is in accordance with the glutamate hypothesis of schizophrenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245040
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    Paper (German National Licenses)
    Fulltext
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