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  • 1
    Electronic Resource
    Electronic Resource
    Overexpression of HSP70 prevents ultraviolet B-induced apoptosis of a human melanoma cell line (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 482-487 
    Details
    ISSN: 1432-069X
    Keywords: Keywords HSP70 ; Human melanoma cells ; Ultraviolet B ; Apoptosis ; Caspase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The heat shock response is a highly conserved reaction common to all cells and organisms. It has been reported that hyperthermic treatment can induce the expression of the heat shock protein (HSP) and can protect cells from ultraviolet (UV) B radiation. In this study, we evaluated the effects of induced HSP70 on resistance to UV radiation. G361 amelanotic human melanoma cells were irradiated with increasing doses of UVB. UVB irradiation caused apoptotic cell death in these cells. Following transfection with MFG.hsp70.puro plasmid, the expression of HSP70 was determined. Compared to control vector-transfected cells, hsp70-transfected cells showed significantly elevated levels of HSP70 and were highly resistant to UVB irradiation. In order to investigate the effects of HSP70 on the apoptotic pathway, the changes in caspase-3 and PARP were analyzed. Following UVB irradiation, activation of caspase-3 and cleavage of PARP were observed in control vector-transfected cells, and the changes in these molecules were inhibited in the hsp70-transfected cells. These results suggest that UVB-induced apoptosis of melanoma cells is accompanied by caspase-3 activation and PARP cleavage, which can be prevented by an overexpression of HSP70.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000173
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An algebraically partitioned FETI method for parallel structural analysis: algorithm description (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 2717-2737 
    Details
    ISSN: 0029-5981
    Keywords: parallel computation ; algebraic partitioning ; domain decomposition ; structural analysis ; finite element method ; iterative solution ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An algebraically partitioned FETI method for the solution of structural engineering problems on parallel computers is presented. The present algorithm consists of three attributes: an explicit generation of the orthogonal null-space matrix associated with the interface nodal forces, the floating subdomain rigid-body modes computed from the subdomain static equilibrium equation of the classical force method and the identification of redundant interface force constraint operator that emanates when the interface force computations are localized. Comparisons of the present method with the previously developed differentially partitioned FETI method are offered in terms of the saddle-point formulations at the end of the paper. A companion paper reports implementation details and numerical performance of the proposed algorithm. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 3
    Electronic Resource
    Electronic Resource
    An algebraically partitioned FETI method for parallel structural analysis: performance evaluation (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 2739-2758 
    Details
    ISSN: 0029-5981
    Keywords: parallel computation ; algebraic partitioning ; domain decomposition ; structural analysis ; finite element method ; iterative solution ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents the algorithmic performance of an algebraically partitioned Finite Element Tearing and Interconnection (FETI) method presented in a companion paper. A simple structural assembly topology is employed to illustrate the implementation steps in a Matlab software environment. Numerical results indicate that the method is scalable, provided the iterative solution preconditioner employs the reduced interface Dirichlet preconditioner. A limited comparison of the present method with the differentially partitioned FETI method with corner modes is also offered. Based on this comparison and a reasonable extrapolation, we conclude the present algebraically partitioned FETI method possesses a similar iteration convergence property of the differentially partitioned FETI method with corner modes. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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