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  • Rat model  (2)
  • renal failure  (2)
  • Appendicitis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Thoracoscopic surgery of the oesophagus in rats: a training concept for the treatment of tracheo-oesophageal malformations in preterm infants (1997)
    Springer
    Pediatric surgery international 12 (1997), S. 116-117 
    Details
    ISSN: 1437-9813
    Keywords: Oesophageal atresia ; Thoracoscopy Laparoscopy ; Rat model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In extremely preterm babies with type Vogt IIIb oesophageal atresia, the primary operative management can be restricted to a gastrostomy and ligation of the fistula. Some of these patients, however, may not even tolerate a thoracotomy or placement on the operating table. We developed a minimally invasive procedure to prepare and ligate the oesophagus thoracoscopically and perform laparoscopic gastrostomy in a rat model. In 15 operations we observed only one complication. This study implies that after adequate practice, thoracoscopic dissection of the oesophagus with ligation of a tracheo-oesophageal fistula could be performed even in every small infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01349975
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Thoracoscopic surgery of the oesophagus in rats: a training concept for the treatment of tracheo-oesophageal malformations in preterm infants (1997)
    Springer
    Pediatric surgery international 12 (1997), S. 116-117 
    Details
    ISSN: 1437-9813
    Keywords: Key words Oesophageal atresia ; Thoracoscopy ; Laparoscopy ; Rat model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In extremely preterm babies with type Vogt III b oesophageal atresia, the primary operative management can be restricted to a gastrostomy and ligation of the fistula. Some of these patients, however, may not even tolerate a thoracotomy or placement on the operating table. We developed a minimally invasive procedure to prepare and ligate the oesophagus thoracoscopically and perform laparoscopic gastrostomy in a rat model. In 15 operations we observed only one complication. This study implies that after adequate practice, thoracoscopic dissection of the oesophagus with ligation of a tracheo-oesophageal fistula could be performed even in every small infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050079
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of nitrendipine in terminal renal failure (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 467-471 
    Details
    ISSN: 1432-1041
    Keywords: nitrendipine ; renal failure ; pharmacokinetics ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and plasma protein binding of nitrendipine in patients with terminal renal failure have been compared with those in subjects with normal renal function. Kinetic parameters were calculated after a single 40 mg oral dose, an i.v. injection of 3 mg and after a 15 mg i.v. infusion of nitrendipine. Steady-state plasma levels were determined after 5 days of oral treatment with 20 mg b.d. Pharmacokinetic parameters and steady-state plasma levels in patients with renal failure did not differ from those in subjects with normal renal function. Nitrendipine was as highly bound to plasma proteins in patients with renal failure, as in subjects with normal renal function. The plasma protein did not differ between the two. The dosage of nitrendipine need not be modified for kinetic reasons in patients with renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558071
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Total and free steady-state plasma levels and pharmacokinetics of nifedipine in patients with terminal renal failure (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 185-189 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; renal failure ; pharmacokinetics ; protein binding ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The total and free steady-state plasma levels of nifedipine in patients with renal failure have been compared with those in subjects with normal renal function. Studies were done after administration of nifedipine 10 mg t.d.s. p.o. for 5 days, after i.v. infusion of 4·4 mg, and after a single 10 mg oral dose. The systemic clearance of nifedipine after a single i.v.-dose was higher in subjects with renal insufficiency (854 ml/min) than in those with normal renal function (468 ml/min). After the single oral dose the AUC (6100 ng·min·ml−1) and maximum plasma concentration (75.0 ng·ml−1) were lower than in subjects with normal renal function (19300 ng·ml−1; 122 ng·ml−1). The plasma protein binding of nifedipine averaged 95.5% in normal subjects and 94.8% in patients with renal failure. Although free and total steady-state plasma levels of nifedipine tended to be somewhat lower than normal in renal failure, the changes in pharmacokinetics and decreased protein binding of nifedipine did not result in a significantly different steady-state plasma level of the drug. The blood pressure response to a given plasma nifedipine level appeared to be enhanced in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558229
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    70. Appendicitis und Meckelsches Divertikel im Kindesalter (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 395-396 
    Details
    ISSN: 1435-2451
    Keywords: Appendicitis ; Meckel's diverticulum and its exploration ; Appendicitis ; Meckelsches Divertikel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Während der letzten 10 Jahre wurden an unserer Kinderchirurgischen Abteilung 82 Kinder mit einem Meckelschen Divertikel operiert. In 70 Fällen erfolgte die operative Entfernung eines M.D. anläßlich von 3636 Appendektomien. Außer bei Vorliegen eines perityphlitischen Abscesses werden routinemäßig die letzten 100 cm des Ileums auf das Vorhandensein eines M.D. überprüft. Es ist üblich, ein M.D. zu resezieren, um späteren Komplikationen vorzubeugen, die durch ein M.D. bedingt sein können.
    Notes: Summary During the last 10 years 82 children with a Meckel's diverticulum were operated at our department of Paediatric Surgery. In 70 cases the operation of M.D. was performed in combination with appendectomies (3,636 cases). Except in cases with a perityphlitic abscess the terminal 100 cm of the ileum should be examined routinely in order to find a M.D. It is a standard to resect a M.D. in order to prevent later complications due to a M.D.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01275895
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    Paper (German National Licenses)
    Fulltext
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