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Immunohistochemical study of arginase in cancer of the stomach (1996)

Wu, C.-W. ; Kao, H.-L. ; Lui, W.-Y. ; [et al.]

Springer

Virchows Archiv 428 (1996), S. 325-331

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ISSN: 1432-2307

Keywords: Arginase ; Gastric cancer ; Immunohistochemistry

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract High levels of arginase have been detected in gastric adenocarcinoma. To examine the hypothesis that this is due to macrophage infiltration into the tumour, we localized the cellular distribution of arginase by immunohistochemical staining. We examined gastric adenocarcinomas and their corresponding normal tissues (n=45), leiomyomas (n=2), leiomyosarcomas (n=3), human gastric adenocarcinoma cell lines (n=3), and benign gastric ulcers (n=4) by the avidin-biotin-peroxidase complex technique. Macrophages with strong arginase immunoreactivity were observed infiltrating both gastric normal and cancer tissues. No arginase immunoreactivity was observed in normal mucosal gland, muscular and serosal tissues or benign gastric ulcers. The immunoreactivity of arginase was positive but heterogeneous in most specimens of gastric adenocarcinoma (62.2%) and was absent from gastric intestinal metaplasia, leiomyomas and leiomyosarcomas. Among the 28 neoplasms with arginase immunoreactivity, scattered immunoreactivity was also noted in adjacent dysplastic glands in 12 (42.8%) specimens. Arginase immunoreactivity was observed in all three gastric cancer cell lines. Arginase is present in the cytoplasm but not in the nucleus. These data suggest that the high arginase levels in adenocarcinoma cancer tissues originate largely from cancer cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00202199

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Fixed bed adsorption drying (1970)

Chi, C. W. ; Wasan, D. T.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 16 (1970), S. 23-31

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: In this paper, mathematical models for a single adsorbate component present in a gas phase have been developed for isothermal and adiabatic dynamic adsorption-desorption processes with special emphasis on adsorption drying by supported hygroscopic salts. The proposed generalized models are applicable to both an unsupported absorbent bed and a fixed bed of adsorbents impregnated on a supporter which may have nonlinear equilibrium relationships. The partial differential equations governing the dynamic adsorption-desorption processes and the nonlinear equilibrium relations were solved numerically on the digital computer.An experimental study was conducted to measure the adsorption and desorption rates of water vapor by lithium chloride impregnated on a solid supporter, Torvex.The proposed adiabatic adsorption-desorption model has been verified for unsupported adsorbent beds in the cases of water vapor adsorption from air by silica gel and of methane adsorption from a helium-methane mixture by activated carbon. The validity of the generalized adiabatic model for supported adsorbent beds with nonlinear equilibrium relationships was established by a direct comparison of experimental data obtained in this study with the predicted values.

Additional Material: 15 Ill.