ISSN:
1432-1440
Keywords:
Heart transplantation
;
Heart ubiquinone
;
Blood and plasma ubiquinone
;
Plasma α-tocopherol
;
Transplant rejection
;
Free radicals
;
Antioxidants
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Nine patients who underwent heart transplantation (one female; average age 48 ± 11, range 19–58 years) were followed in respect to contents of right-sided heart septum, blood and plasma ubiquinone (UQ), plasma α-tocopherol (αT), and plasma free cholesterol (FC). In contrast to healthy persons, substantial inter- and intraindividual variations were observed; individually low values were seen with rejection. Heart muscle UQ in well-treated patients averaged 0.33 ± 0.08, range 0.06–0.58 μg mg−1 (0.38 ± 0.09 μmol g−1 dry weight) and was not different from healthy individuals. Plasma UQ, αT; and FC averaged 0.63 ± 0.33 μg ml−1 (P 〈 0.05 versus sedentary controls), 8.1 ± 4.0 μg ml−1 (P 〈 0.01), and 0.52 ± 0.23 mg ml−1 (P 〈 0.05). Corresponding molar values were 0.73 ± 0.37 (UQ), 2.0 ± 1.1 μmol l−1 (αT), and 1.42 ± 0.54 mmol 1−1 (FC). Blood and plasma UQ values were identical. A saturationlike relationship was found between heart and blood UQ: blood contents below 0.7 μg ml−1 (0.8 μmol l−1) corresponded to markedly lowered heart contents. In four patients in whom blood samples were taken close to a fatal complication it averaged 0.42 μg ml−1 (0.49 μmol l−t, P 〈 0.01). When low heart muscle and blood ubiquinone were present, other variables such as left ventricle cardiac output or cycle ergometer performance was markedly impaired. Plasma UQ and off covaried with a marker of the lipoidal deposit volume, plasma FC. The ratios UQ and αT over FC (N-UQ and N-αT) are alternative means for clinical evaluation. Mean N-αT was relatively more depleted than N-UQ. On an individual basis this was more pronounced for those with low N-UQ than for those with high values.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00226845
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