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  • 1
    Electronic Resource
    Electronic Resource
    The effect of human growth hormone therapy on L-(Methyl-2H3)-leucine turnover and urinary pseudouridine concentration in patients with Ullrich-turner syndrome (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 275-280 
    Details
    ISSN: 1432-1076
    Keywords: Ullrich-Turner syndrome ; Human growth hormone ; Growth rate ; L-(methyl-2H3)-leucine ; Pseudouridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abstract The effect of daily human growth hormone (hGH) injections (3 I.U./m2/day) on tissue anabolism was determined in six patients with Ullrich-Turner syndrome (XO) (8.7–19 years of age) using novel techniques such as whole body leucine kinetics during continuous infusion of L-(Methyl-2H3)-leucine and urinary pseudouridine (5-ribosyluracil) excretion on the one hand and traditional methods like serum urea and amino acid concentrations on the other. Pseudouridine is only found in ribonucleic acid (RNA) and is neither reincorporated nor catabolically broken down and is therefore considered an ideal index of whole body RNA turnover. The mean L-(Methyl-2H3)-leucine turnover of the six XO patients before hGH was 1.90±0.15 μmoles/kg per minute. After 3 months of hGH-treatment it had increased in three patients, whereas it had decreased in the other three. The results obtained with the stable isotope technique were correlated with the urinary pseudouridine concentrations (r=0.68;P〈0.01). The growth rates were positively correlated with leucine turnover (r=0.63;P〈0.02) and urinary pseudouridine concentration (r=0.73;P〈0.006) as well as negatively correlated with the serum urea concentrationsr=−0.62;P〈0.03). The decrease in the individual serum urea concentrations were tightly correlated with the hGH induced change in growth rate (r=0.90;P〈0.01). The individual bone ages were negatively correlated with the hGH induced changes in leucine turnover (r=−0.77;P〈0.003) as well as with the urinary pseudouridine concentrations (r=−0.87P〈0.0002). The hGH effect on leucine and RNA turnover, showing effectiveness only until a developmental age between 11 and 12 years, leads the discussion of the ideal moment of oestrogen supplementation when girls with Ullrich-Turner syndrome are treated with hGH in early adolescence. Conclusion The protein metabolism of patients with Ullrich-Turner syndrome is influenced by hGH in an age dependent manner. In a clinical setting, pseudouridine, an easily determined derivative of ribonucleic acids, may be able to replace the tedious work with expensive stable isotopes when questions related to tissue anabolism are to be answered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02002712
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of human growth hormone therapy on L-(Methyl-2H3)-leucine turnover and urinary pseudouridine concentration in patients with Ullrich-Turner syndrome (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 275-280 
    Details
    ISSN: 1432-1076
    Keywords: Key words Ullrich-Turner ; syndrome ; Human growth hormone ; Growth rate ; L-(methyl-2H3)-leucine ; Pseudouridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of daily human growth hormone (hGH) injections (3 I.U./m2/day) on tissue anabolism was determined in six patients with Ullrich-Turner syndrome (XO) (8.7–19 years of age) using novel techniques such as whole body leucine kinetics during continuous infusion of L-(Methyl-2H3)-leucine and urinary pseudouridine (5-ribosyluracil) excretion on the one hand and traditional methods like serum urea and amino acid concentrations on the other. Pseudouridine is only found in ribonucleic acid (RNA) and is neither reincorporated nor catabolically broken down and is therefore considered an ideal index of whole body RNA turnover. The mean L-(Methyl-2H3)-leucine turnover of the six XO patients before hGH was 1.90 ± 0.15 μmoles/kg per minute. After 3 months of hGH-treatment it had increased in three patients, whereas it had decreased in the other three. The results obtained with the stable isotope technique were correlated with the urinary pseudouridine concentrations (r = 0.68; P 〈 0.01). The growth rates were positively correlated with leucine turnover (r = 0.63; P 〈 0.02) and urinary pseudouridine concentration (r = 0.73; P 〈 0.006) as well as negatively correlated with the serum urea concentrations r = –0.62; P 〈 0.03). The decrease in the individual serum urea concentrations were tightly correlated with the hGH induced change in growth rate (r = –0.90; P 〈 0.01). The individual bone ages were negatively correlated with the hGH induced changes in leucine turnover (r = –0.77; P 〈 0.003) as well as with the urinary pseudouridine concentrations (r = –0.87; P 〈 0.0002). The hGH effect on leucine and RNA turnover, showing effectiveness only until a developmental age between 11 and 12 years, leads the discussion of the ideal moment of oestrogen supplementation when girls with Ullrich-Turner syndrome are treated with hGH in early adolescence. Conclusion The protein metabolism of patients with Ullrich-Turner syndrome is influenced by hGH in an age dependent manner. In a clinical setting, pseudouridine, an easily determined derivative of ribonucleic acids, may be able to replace the tedious work with expensive stable isotopes when questions related to tissue anabolism are to be answered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050400
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    109. Ergebnisse nach chirurgischer Behandlung der aorto-iliacalen Verschlußkrankheit (1982)
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 465-465 
    Details
    ISSN: 1435-2451
    Keywords: Arteriosclerosis obliterans ; Operative approach ; Bifurcated prosthesis ; Long-term results ; Arteriosklerosis obliterans ; operativer Zugang ; Bifurkationsprothese ; Langzeitergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Berichtet wird über 874 gefäßchirurgische Eingriffe im aorto-iliacalen Abschnitt in 10 Jahren, hiervon 589 Bifurkationsprothesen. Extraanatomische Verfahren sowie einseitiger Bypass und TEA schneiden funktionell deutlich schlechter ab als die Rekonstruktion mit einer Bifurkationsprothese. In dieser Gruppe sind die Ergebnisse des transperitonealen Vorgehens (401 Op.) gegenüber dem extraperitonealen (188 Op.) deutlich besser. Dies gilt sowohl für die Durchgängigkeit, schmerzfreie Gehstrecke und Spätkomplikationen, als auch für die Langzeitüberlebensrate. Daher sollte die transperitoneale Bifurkationsprothese das Verfahren der Wahl sein.
    Notes: Summary Report on 874 cases of vascular surgery in the aortoiliac region over a period of 10 years. Of these, 589 were bifurcated prostheses. Extra-anatomical procedures, as well as unilateral bypass and TEA were functionally very inferior to reconstruction by means of bifurcated prostheses. In this group, the results of the transperitoneal approach (401 operations) were distinctly better than those of the extraperitoneal approach (188 operations) with regard to patency, walking distance and later complications, as well as long-term survival. Therefore, the transperitoneal bifurcated prosthesis should be the procedure of choice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271856
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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