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  • 1
    Electronic Resource
    Electronic Resource
    Effects of cyclosporin on serum hyaluronan levels in collagen arthritis (1995)
    Springer
    Inflammation research 44 (1995), S. 79-82 
    Details
    ISSN: 1420-908X
    Keywords: Collagen ; Arthritis ; Cyclosporin and hyaluronan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01793217
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