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  • 1
    Electronic Resource
    Electronic Resource
    Experimental Study of an Artificial Esophagus Using a Collagen Sponge, a Latissimus Dorsi Muscle Flap, and Split-Thickness Skin (2000)
    Springer
    Surgery today 30 (2000), S. 606-613 
    Details
    ISSN: 1436-2813
    Keywords: Key Words Artificial esophagus ; Collagen sponge ; Artificial dermis ; Split-thickness skin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time and effort spent trying to devise an artificial esophagus have not yet resulted in success, and leakage and strictures at the anastomotic sites remain the most frequent complications. We developed an artificial esophagus with a bilayered structure made of porous collagen sponge (artificial dermis; AD), a latissimus dorsi muscle flap (LD), and split-thickness skin (STS). We investigated whether the use of AD prevented the contraction of grafted skin and its effects on the extensibility of the neoesophagus in rabbits. We experimented with two groups. In the AD group, AD was applied to the surface of the LD. Three weeks later, the STS was grafted. In the control group, the STS was grafted directly onto the LD. The sizes of the STS in both groups 3 weeks after the graft were, respectively, 56.6% ± 4.1% and 39.0% ± 10.2% of the initial surface area of the STS (P 〈 0.01). The roll made in the AD group had better extensibility than that in the control group. We replaced the cervical esophagus in 12 rabbits with the neoesophagus made from AD, STS, and LD. The longest survival period was 16 days. Esophagography did not reveal either anastomotic leakage or stenosis in any of the five rabbits in the experiments. These findings suggested that AD can thus be used to create a more suitable hybrid artificial esophagus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950070100
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Systemic chemotherapy using cisplatin plus 5-fluorouracil for inoperable gallbladder cancer (1997)
    Springer
    Journal of hepato-biliary-pancreatic surgery 4 (1997), S. 131-134 
    Details
    ISSN: 1436-0691
    Keywords: inoperable gallbladder cancer ; chemotherapy ; CDDP ; 5-FU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of advanced gallbladder cancer in a 37-year-old man who presented in June 1993 with malignant obstructive jaundice. After percutaneous transhepatic biliary drainage and several diagnostic imaging examinations, the patient underwent laparotomy under a diagnosis of extremely advanced gallbladder cancer involving the confluence of the hepatic ducts. The tumor, however, was judged to be unresectable because of its massive spread into the liver along Glisson's sheath, and because of histologically proven peritoneal dissemination. After exploratory laparotomy, one course of anticancer chemotherapy (cisplatin, 100 mg/body IV, on day 1, and 5-fluorouracil, 1000 mg/body, on days 1–5, by continuous infusion) was administered and the completely obstructed hepatic duct was dramatically re-canalized. Four courses of chemotherapy were administered over a 16-month period until jaundice recurred. For these 16 months, the patient's quality of life was well maintained without biliary drainage. He died of increased peritoneal dissemination approximately 2 years after the first course of anticancer chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211355
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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