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  • 1
    Electronic Resource
    Electronic Resource
    Corneal infection of herpes simplex virus type 2 – induced neuronal apoptosis in the brain stem of mice with expression of tumor suppressor gene (p53) and transcription factors (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 647-653 
    Details
    ISSN: 1432-0533
    Keywords: Key words HSV ; Immunohistochemistry ; Apoptosis ; p53 ; Transcription factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To understand the mechanism of neuronal apoptosis induced by herpes simplex virus (HSV) infection in vivo, the distribution of viral antigen, the appearance of apoptotic bodies, and the expressions of the tumor suppressor gene p53 and several transcription factors such as c-fos, c-jun and NF-κB were examined immunohistochemically and histopathologically after corneal infection of mice with HSV type 2 strain 186. Five days after HSV infection, viral antigen was diffusely detected in the corneal epithelium, the trigeminal ganglion and the pars caudalis of the spinal trigeminal nucleus. Neuronal apoptosis was observed in the brain stem ipsilateral to the HSV-infected side with the immunoreactivities of c-fos, c-jun, NF-κB and p53. Dual-labeling immunohistochemical studies revealed that almost all of the viral antigen-positive neurons and glia in the brain stem also showed p53 immunoreactivity. On the other hand, no neuronal apoptosis but only with the expression of c-jun was found in the trigeminal ganglion. Our results suggest that the different expression of transcription factors between the brain stem and the trigeminal ganglion may influence the neuronal apoptosis induced by HSV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010000240
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  • 2
    Electronic Resource
    Electronic Resource
    Electron wave interference device with fractional layer superlattices (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 58 (1991), S. 376-378 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Modulation-doped Al0.3Ga0.7As/GaAs heterostructure electron wave interference devices with fractional layer superlattices are fabricated. The periods of the fractional layer superlattice in the electron wave interference devices are 16, 12, and 8 nm, respectively. These devices show drain current oscillation due to electron wave interference at 4.2 K. The oscillation period is determined by the period of the fractional layer superlattice. From the analysis of the drain current oscillation, the peaks of the structure function agree with the multiples of the periods of the fractional layer superlattice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.104639
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  • 3
    Electronic Resource
    Electronic Resource
    Atrial Ectopy Originating from the Posteroinferior Atrium During Radiofrequency Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 22 (1999), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Atrial ectopy sometimes appears during RF ablation of the slow pathway in patients with atrioventricular nodal reentrant tachycardia (AVNRT). However, its origin, characteristics, and significance are still unclear. To examine these issues, we analyzed 67 consecutive patients with AVNRT (60 with slow-fast AVNRT and 7 with fast-slow AVNRT), which was successfully eliminated by RF ablation to the sites with a slow potential in 63 patients and with the earliest activations of retrograde slow pathway conduction in 4 patients. During successful RF ablation, junctional ectopy with the activation sequence showing H-A-V at the His-bundle region appeared in 52 patients (group A) and atrial ectopy with negative P waves in the inferior leads preceding the QRS and the activation sequence showing A-H-V at the His-bundle region appeared in 15 patients (group B). Atrial ectopy was associated with (10 patients) or without junctional ectopy (5 patients). Before BF ablation, retrograde slow pathway conduction induced during ventricular burst and/or extrastimulus pacing was more frequently demonstrated in group B than in group A (9/15 [60%] vs 1/52 [2%], P 〈 0.001). Successful ablation site in group A was distributed between the His-bundle region and coronary sinus ostium, while that in group B was confined mostly to the site anterior to the coronary sinus ostium. In group B, atrial ectopy also appeared in 21 % of the unsuccessful RF ablations. In conclusion, atrial ectopy is relatively common during slow pathway ablation and observed in 8% of RF applications overall and 22% of RF applications that successfully eliminated inducible AVNRT. Atrial ectopy appears to be closely related to successful slow pathway ablation among patients with manifest retrograde slow pathway function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.1999.tb00536.x
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  • 4
    Electronic Resource
    Electronic Resource
    Accerelation of Wound Healing with PDWHF and Cultured Cells (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective:  Effects of platelet derived wound healing factor (PDWHF)1) with or without cultured cells on angiogenesis in treatment of defected wounds using artificial dermis (AD) were investigated in rat experimental model.Methods:  Wistar strain rats were used for this study. The PDWHF was prepared from platelets. The endothelial cells and fibroblasts were prepared from thoracic aorta and back skin respectively. Two sites of 2.5 × 2.5 cm full-thickness wounds were created on back of the animals. Artificial dermis (TERUDERMIS®, TERUMO Co, Japan) were grafted to the wounds. Prior to the AD grafts, following 4 groups were established, control group: AD alone (n = 6), PDWHF group: AD treated with PDWHF (0.1 ml/cm2)(n = 6), cultured cells group: disperse of 1 × 105 cultured endothelial cells and fibroblasts between AD and wound (n = 6) and combination group: combination of PDWHF and cultured cells (n = 6). Five days after surgery, degree of angiogenesis was evaluated by gross inspection and histological study. Evans blue perfusions test was performed to evaluate the degree of new capillary formation in the generated dermis quantitatively.Results:  The combination group showed vascular invasion into AD 5 days after surgery. In this group, the absorbance of the Evans blue extracted from the grafted dermis was highest among the group.Conclusion:  The result of the present study revealed that treatment with PDWHF combined with cultured endothelial cells and fibroblasts accelerate the wound angiogenesis. This method may be beneficial to shorten the period between the AD grafts and the secondary skin grafting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116ao.x
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental Study of an Artificial Esophagus Using a Collagen Sponge, a Latissimus Dorsi Muscle Flap, and Split-Thickness Skin (2000)
    Springer
    Surgery today 30 (2000), S. 606-613 
    Details
    ISSN: 1436-2813
    Keywords: Key Words Artificial esophagus ; Collagen sponge ; Artificial dermis ; Split-thickness skin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time and effort spent trying to devise an artificial esophagus have not yet resulted in success, and leakage and strictures at the anastomotic sites remain the most frequent complications. We developed an artificial esophagus with a bilayered structure made of porous collagen sponge (artificial dermis; AD), a latissimus dorsi muscle flap (LD), and split-thickness skin (STS). We investigated whether the use of AD prevented the contraction of grafted skin and its effects on the extensibility of the neoesophagus in rabbits. We experimented with two groups. In the AD group, AD was applied to the surface of the LD. Three weeks later, the STS was grafted. In the control group, the STS was grafted directly onto the LD. The sizes of the STS in both groups 3 weeks after the graft were, respectively, 56.6% ± 4.1% and 39.0% ± 10.2% of the initial surface area of the STS (P 〈 0.01). The roll made in the AD group had better extensibility than that in the control group. We replaced the cervical esophagus in 12 rabbits with the neoesophagus made from AD, STS, and LD. The longest survival period was 16 days. Esophagography did not reveal either anastomotic leakage or stenosis in any of the five rabbits in the experiments. These findings suggested that AD can thus be used to create a more suitable hybrid artificial esophagus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950070100
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  • 6
    Electronic Resource
    Electronic Resource
    Shot Peening and Fatigue Crack Growth in 7075-T7351 Aluminum (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 297-300 (Nov. 2005), p. 72-77 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Thirty three SENB and nine TPB specimens, which were machined from an 8.1mm thick 7075-T7351 aluminum stock plate, were fatigued in the as-received or shot peened conditions. The SENB specimens were then fractured by overload and were recorded. The crack growth rate of the tunneling crack profiles were measured by fractography at various life cycles. SN curves of the as received and shot peened TPB specimens were also constructed. Peened surface roughness, subsurface microstructure and micro-hardness profiles were examined. X-ray diffraction technique was used to measure the residual stresses in selected shot peened SENB and TPB specimens. The fatigue life under a severe shot peening intensity (Almen scale 0.016A) of the SENB specimens was slightly larger than that of the as received SENB specimens at low stress ratio of R = 0.1 but the difference was found to be smaller at R = 0.8. The SN curves of the as received and severely shot peened TPB specimens were nearly identical. Grain distortion due to peening was observed to a depth of 410µm and was correlated with the measured residual compressive stresses. The compressive residual stress had little effect on the crack growth rates in shot peened SENB and TPB specimens
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/50/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.297-300.72.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    A case of distal 4q trisomy due to familial (4;5)(q31;p15) translocation (1978)
    Springer
    Journal of human genetics 23 (1978), S. 167-172 
    Details
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A boy with multiple anomalies including atresia of the esophagus, ventricular septal defect, horseshoe kidney and some minor anomalies is described. His karyotype was 46,XY, der(5), t(4;5) (q31;p15)pat,i.e., he was partially trisomic for a distal segment of long arm of no.4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02001799
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