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  • 1
    Electronic Resource
    Electronic Resource
    Gesteigerte Demethylierung von Aminophenazon unter antikonvulsiver Langzeitbehandlung (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 677-679 
    Details
    ISSN: 1432-1440
    Keywords: Demethylation ; Aminopyrine ; Drugs metabolism ; Antiepileptic drugs ; Calcium absorption ; Diphenylhydantoin ; Microsomal enzyme system ; Aminophenazon, Demethylierung ; Arzneimittelstoffwechsel ; Mikrosomales Enzymsystem ; Antiepileptika ; Calciumstoffwechsel ; Diphenylhydantoin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Demethylierung von Aminophenazon wurde bei 25 Lebergesunden ohne Medikamenteneinnahme und 19 Epileptikern unter antikonvulsiver Langzeitbehandlung mittels des14C-Aminophenazon-Atemtestes untersucht. Im Vergleich zur Kontrollgruppe bestand bei Epileptikern unter antikonvulsiver Langzeitbehandlung eine gesteigerte Demethylierung für14C-Aminophenazon (kumulative14CO2-Exhalation: nach 1/2 h 88,7%, nach 2 h 62,6% und nach 8 h nur noch 24,8%). Der14C-Aminophenazon-Exhalationstest läßt sich nicht nur zur Erkennung einer verminderten Demethylierung der Leber bei chronischen Lebererkrankungen, sondern auch zur Erfassung einer gesteigerten Demethylierungsfunktion bei Patienten unter induzierenden Pharmaka verwenden.
    Notes: Summary Demethylation of aminopyrine was measured in 25 healthy controls and 19 epileptics on long-term treatment with anticonvulsants by the14C-aminopyrine breath test. Compared to controls epileptics exhibited increased cumulative14CO2-exhalation rates (88.7% at 30 min, 62.6% at 2 h and 24.8% at 8 h) following ingestion of 2 µCi14C-aminopyrine. The results suggest that long-term treatment with antiepileptic drugs results in increased demethylating function of the liver which can be easily detected by a simple breath analysis technique like decreased demethylation in chronic liver disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477022
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of salicylate on HCO 3 − /Cl− exchange across the human erythrocyte membrane (1982)
    Springer
    The journal of membrane biology 65 (1982), S. 139-145 
    Details
    ISSN: 1432-1424
    Keywords: salicylate ; erythrocyte ; anion exchange ; pH ; DIDS ; CO2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Changes in extracellular pH (pH o ) in human red cell suspensions were monitored in a stopped-flow rapid reaction apparatus. A 20% suspension of washed human RBC in saline at pH 7 containing NaHCO3 and extracellular carbonic anhydrase was mixed with an equal volume of buffered saline solution at pH 6.7. Sodium salicylate, when present, was added to both the erythrocyte suspension and the buffer solution. The effects of salicylate in the therapeutic to toxic concentration range on HCO 3 − /Cl− exchange were studied at 37°C. HCO 3 − /Cl− exchange flux was estimated using the extracellular buffer capacity and the difference betweendpH o /dt using a control RBC suspension and that using a suspension of RBC whose anion exchange pathway was markedly inhibited. The results show that salicylate competitively decreases the rate of HCO 3 − /Cl− exchange, with inhibition increasing as salicylate concentration increases.K I is ∼2.4mm. At a salicylate concentration of 10mm, HCO 3 − /Cl− exchange under the conditions of our experiments was inhibited by more than 70%. These findings are consistent with the possibility that CO2 transfer in capillary bedsin vivo may be diminished in the presence of salicylate due to slowing of red cell HCO 3 − /Cl− exchange.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870477
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    Paper (German National Licenses)
    Fulltext
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