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  • 1
    ISSN: 1432-1440
    Keywords: AIDS ; Autopsy ; Histopathology ; HIV ; Opportunistic infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty consecutive AIDS autopsy cases were evaluated. All subjects showed one or more opportunistic infections and malignancies included in the AIDS case definition with cytomegalovirus and Kaposi's sarcoma being most prevalent. Mycobacterial and cryptococcal infections occurred only infrequently. Most patients of our series after successful treatment ofPneumocystis carinii pneumonia or cerebral toxoplasmosis later succumbed to less treatable conditions like disseminated cytomegalovirus or fungal infections or malignant lymphoma. In the absence of specific treatment for the HIV infection leading to these lethal complications special emphasis must be put on the prevention of HIV transmission and spread.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0878
    Keywords: Human spleen ; Sinus lining cells ; Pulp veins ; Histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sinus and venous walls of normal human spleens were studied with enzyme histochemical and electron microscopic methods. Particular attention was paid to the connections between sinuses and veins. Histochemically the sinus lining cells revealed a distinct naphthol-AS-acetate-esterase activity but no reaction for alkaline phosphatase. Venous endothelial cells were positive for the latter but negative for the former enzyme. In the sinusvenous junctional area there were no endothelial cells with reactivity for both enzymes. Electron microscopically both the sinus lining cells and the venous endothelial cells could be clearly characterized and therefore easily distinguished from one another on morphological grounds. There were no clear ultrastructural indications of transitional forms between sinus lining cells and venous endothelial cells in the sinus-venous area. According to these findings, sinus lining cells represent a specialized endothelium, but one with practically no morpholgical similarities to the venous endothelium.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 151 (1974), S. 337-342 
    ISSN: 1432-0878
    Keywords: Spleen ; Sinus lining cells ; Desmosomes ; Intercellular junctions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 13 normal and pathological human spleens were studied by electron microscopy. In four cases (1 chronic myeloid leukemia, 1 haemolytic anaemia, 1 idiopathic thrombocytopenic purpura, 1 traumatic capsular lesion) intercellular junctions between sinus lining cells were found. These included tight junctions, “close junctions”, and intermediate junctions. There were no desmosomes. Such intercellular junctions have not been observed previously in human spleens and occur only rarely. They are thus unevenly distributed. This indicates that they probably do not impede the migration of cells through the sinus wall.
    Type of Medium: Electronic Resource
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