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  • 1
    Electronic Resource
    Electronic Resource
    Breast cancer staging using technetium-99m sestamibi and indium-111 pentetreotide single-photon emission tomography (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 192-196 
    Details
    ISSN: 1619-7089
    Keywords: Breast cancer ; Axillary lymph nodes ; Technetium-99m sestamibi ; Indium-111 pentetreotide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the clinical usefulness of single-photon emission tomography (SPET) with technetium-99m sestamibi and indium-111 pentetreotide in breast cancer staging. Fifteen patients with clinical and/or mammographic findings suggesting T1-2N0-1 breast cancer were studied. SPET images were acquired 20 min after99mTc-sestamibi injection and 4 and 24 h after111In-pentetreotide injection. Patients underwent surgery the day after the later111In-pentetreotide acquisition. Pathological examination showed 16 tumours in the 15 patients, with one bilateral carcinoma. The mean tumour diameter was 18.7 mm. Metastatic axillary involvement was found in 6/16 tumours, with a mean of five metastatic nodes per axilla. Both tracers correctly identified 15/16 primary tumours and five of the six cases of metastatic axillary node involvement. No difference between the tracers was observed in breast cancer staging.99mTc-sestamibi seems to be the better tracer in terms of physical characteristics, execution time and cost-effectiveness. Our data suggest the future possibility of using nuclear medicine imaging to avoid axillary dissection in patients with T1 breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02439552
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  • 2
    Electronic Resource
    Electronic Resource
    Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 597-600 
    Details
    ISSN: 1619-7089
    Keywords: Myocardial perfusion ; Tc radiopharmaceutical ; biodistribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hexakis (methoxyisobutilisonitrile) technetium(I), 99mTc-MIBI, has been proposed for myocardial perfusion studies. We have evaluated the biodistribution of this new agent in normal volunteers at rest and after stress. The biodistribution of 99mTc-MIBI is characterized by rapid blood clearance and a consequently early myocardial uptake. The initial intense hepatic activity is cleared into the gallbladder at 1 h after injection, and the best target to non target ratio is observed at 60–90 min after injection. Absorbed radiation dose calculations show that the thyroid is the critical target organ (230 mRad/mCi at rest), presumably because of 99mTc-pertechnetate generated in vivo. Our results indicate that 99mTc-MIBI is a promising tracer for myocardial perfusion imaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256936
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 308-311 
    Details
    ISSN: 1619-7089
    Keywords: Sestamibi ; Brain tumour ; Relapse ; Radiation necrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One of the main problems regarding the follow-up of patients with brain tumours treated with radiotherapy is the distinction between radiation necrosis and tumour relapse. In many cases computed tomography (CT) scan is unable to distinguish between the two. We assessed the usefulness of brain single-photon emission tomography (SPET) with technetium-99m-sestamibi in cases where CT scan was not conclusive. The absence of tracer uptake in normal brain, the sharp uptake in neoplastic tissue, and the favourable physical properties of technetium make the scintigraphic method particularly accurate. We therefore propose the association of CT scan with99mTc-sestamibi brain SPET in the follow-up of patients in whom a distinction between radiation necrosis and active disease is needed for an adequate therapeutic decision.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00837629
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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