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  • 1
    Electronic Resource
    Electronic Resource
    Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 597-600 
    Details
    ISSN: 1619-7089
    Keywords: Myocardial perfusion ; Tc radiopharmaceutical ; biodistribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hexakis (methoxyisobutilisonitrile) technetium(I), 99mTc-MIBI, has been proposed for myocardial perfusion studies. We have evaluated the biodistribution of this new agent in normal volunteers at rest and after stress. The biodistribution of 99mTc-MIBI is characterized by rapid blood clearance and a consequently early myocardial uptake. The initial intense hepatic activity is cleared into the gallbladder at 1 h after injection, and the best target to non target ratio is observed at 60–90 min after injection. Absorbed radiation dose calculations show that the thyroid is the critical target organ (230 mRad/mCi at rest), presumably because of 99mTc-pertechnetate generated in vivo. Our results indicate that 99mTc-MIBI is a promising tracer for myocardial perfusion imaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256936
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Spatial registration of echocardiographic and positron emission tomographic heart studies (1995)
    Springer
    European journal of nuclear medicine 22 (1995), S. 243-247 
    Details
    ISSN: 1619-7089
    Keywords: Echocardiography ; Positron emission tomography ; Fluorine-18-fluoro-2-deoxy-d-glucose ; Registration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method has been developed to match corresponding heart regions from functional echocardiographic (Echo) and metabolic fluorine-l8-fluoro-2-deoxy-d-glucose ([18F]FDG) positron emission tomography (PET) studies in individual patients. Echo and PET images are spatially correlated by determining homologous anatomical landmarks (the two papillary muscles and the inferior junction of the right ventricle), identifiable in images obtained by both acquisition modalities. Echo-PET image registration is first performed in the plane identified by the three landmarks, using a rigid rotate-translate scale model. The registration parameters are then used to transform the whole PET volume. This allows a consistent Echo-PET regional analysis, according to a segmental subdivision of the heart. The technique was tested on patients. The overlay of Echo and PET registered images proved the reliability of realignment of the three markers and a good spatial correlation of myocardial walls. This approach to image registration could be applied to other acquisition modalities (such as magnetic resonance imaging and single-photon emission tomography), provided that the three anatomical landmarks are visualized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01081520
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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