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  • Axonal transport  (2)
  • C-peptide  (1)
  • Clinical experience  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Prospective comparative study in NIDDM patients of metformin and glibenclamide with special reference to lipid profiles (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 263-265 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Metformin ; Glibenclamide ; NIDDM ; lipoproteins ; C-peptide ; diabetes mellitus ; adverse effects ; serum lipids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary. Twenty-two NIDDM patients completed an open randomized cross-over study comparing metformin and glibenclamide over 1 year. The drugs had an equivalent effect on glycaemic control, but, in contrast to glibenclamide, metformin reduced body weight. Neither drug affected triglycerides, total-and LDL-cholesterol or C-peptide. Metformin caused a slight elevation of HDL-cholesterol (P 〈 0.05). No serious adverse effects were observed. The results show that oral hypoglycaemic agents are not associated with undesirable effects on lipids and lipoproteins.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00315441
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Preclinical safety assessment of contrast media: predictive value (1996)
    Springer
    European radiology 6 (1996), S. S3 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Contrast media ; Preclinical safety assessment ; Clinical experience
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The purpose of preclinical tests is to identify the potential benefits and risks of new diagnostic or therapeutic products. Regarding iodinated contrast media (CM), LD50 tests were used extensively in the past. However, from both scientific and ethical perspectives it is today highly relevant to question the use of LD50 tests. Due to species differences and the very high volume of CM needed to kill half of the animals, such tests are not sensitive enough to differentiate between modern nonionic CM. Further, they are not very predictive in terms of human tolerability. In other tests with more relevant end-points than death, overall tolerance to the new dimeric compound iodixanol (Visipaque), representing the latest step in the development of CM, has been shown to be higher than to tire nonionic monomers. Clinical experience has shown that the physiological parameters often stay closer to baseline alter Visipaque than after administration of conventional CM.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02342564
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  • 3
    Digitale Medien
    Digitale Medien
    Evidence for axonal transport of RNA in mammalian neurons (1973)
    Springer
    Experimental brain research 16 (1973), S. 501-506 
    Details
    ISSN: 1432-1106
    Schlagwort(e): RNA ; Axonal transport ; Optic pathway
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Adult albino rabbits were injected into one eye with (3H) uridine. At various time intervals following the injections the amount of RNA-bound and acid soluble radioactivity was measured in the retrobulbar optic pathway. Evidence was obtained for a relatively slow transport of a small amount of macromolecular RNA along the axons of the retinal ganglion cells down to the nerve terminals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00234476
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of colchicine on axonal transport and morphology of retinal ganglion cells (1971)
    Springer
    Cell & tissue research 115 (1971), S. 265-283 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Axonal transport ; Retina ; Colchicine ; Ultrastructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Intraocular injection of colchicine in doses which do not affect the protein synthesis in the retina has profound effects on the axonal transport of protein in the retinal ganglion cells of the rabbit. Rapid axonal transport in these cells is completely inhibited after treatment with relatively low amounts of colchicine. In contrast to this, a certain fraction of the slow axonal transport is resistant to colchicine treatment. Colchicine in doses which completely inhibits fast axonal transport caused discrete morphological changes in the perikaryon and in the axon of the retinal ganglion cell. No disappearance of microtubules and no general proliferation of neurofilaments was observed in the perikaryon of the retinal ganglion cells. There was a slight or moderate increase in the number of filaments in the intra-retinal part of the axons of the retinal ganglion cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00391128
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